公开(公告)号：US20230381723A1

公开(公告)日：2023-11-30

申请号：US17826943

申请日：2022-05-27

申请人： Hewlett-Packard Development Company, L.P.

发明人： Carson Denison ,  Richard W. SEAVER ,  Erik D. TORNIAINEN ,  Pavel KORNILOVICH ,  Alexander GOVYADINOV ,  Anand Samuel JEBAKUMAR ,  Oumnia EL FAJRI

IPC分类号： B01F33/3012 ,  B01F35/71

CPC分类号： B01F33/3012 ,  B01F35/7172 ,  B01F2101/2204

摘要： An example microfluidic mixer can include an inlet microfluidic channel portion and a fluid splitting channel portion including an overpass microfluidic channel to receive fluid from a first side of the inlet microfluidic channel portion and an underpass microfluidic channel to receive fluid from a second side of the inlet microfluidic channel portion, where the underpass microfluidic channel extends under the overpass microfluidic channel such that the channels overlap at their respective downstream ends. A fluid recombining channel portion is downstream of the fluid splitting portion and includes an angled recombining surface having an acute angle with respect to a direction of fluid flow, where the angled recombining surface is between the downstream ends of the overpass and underpass microfluidic channels. An outlet microfluidic channel portion is fluidly connected downstream from the fluid recombining channel portion.

公开(公告)号：US20240050908A1

公开(公告)日：2024-02-15

申请号：US18259439

申请日：2021-12-27

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Michael J. MITCHELL ,  David Aaron ISSADORE ,  Sagar Prasad YADAVALI ,  Sarah J. SHEPHERD

IPC分类号： B01F33/3012 ,  B01F25/431 ,  B01F23/41 ,  B01F23/45 ,  A61K9/50 ,  A61K48/00 ,  A61K39/215

CPC分类号： B01F33/3012 ,  B01F25/43172 ,  B01F25/431971 ,  B01F23/4143 ,  B01F23/4105 ,  B01F23/45 ,  A61K9/5089 ,  A61K48/0041 ,  A61K39/215 ,  B01F2101/22

摘要： Provided are scalable, parallelized microfluidic chips that include arrays of microfluidic mixing channels for large-scale production of lipid nanoparticles, among other products. The disclosed chips can operate with a single set of inlets and outlet, and achieve production rates in excess of those achieved by existing methods. The disclosed devices provide large-scale production of formulations while still maintaining the physical properties and potency typical of existing methods of producing such formulations. Also provided are related methods of using the disclosed devices.

公开(公告)号：US20240017224A1

公开(公告)日：2024-01-18

申请号：US18036609

申请日：2021-11-22

申请人： JAPAN SCIENCE AND TECHNOLOGY AGENCY

发明人： Takashi NISISAKO

IPC分类号： B01F33/3012 ,  C08L29/04 ,  B81B1/00 ,  B01F33/30 ,  B01F23/41

CPC分类号： B01F33/3012 ,  C08L29/04 ,  B81B1/00 ,  B01F33/30351 ,  B01F23/4105 ,  B01F23/4143 ,  C08L2201/52 ,  B01F2215/0486

摘要： The present invention provides a micro two-phase droplet generating device that does not require separate through-holes corresponding to a plurality of two-phase dispersed parallel continuous flow channels. The micro two-phase droplet generating device of the present application comprises a row of a plurality of microflow channels, liquid transfer ports, and a slit, and is configured so as to form two-dispersion phase parallel continuous flows at first connection sites between the plurality of microflow channels, in which a first dispersion phase flows, and the slit, through which a second dispersion phase flows. A continuous phase is fed to second connection sites between the plurality of microflow channels, in which the two-dispersion phase parallel continuous flows flow, and another liquid transfer port, which is preferably a second slit, downstream of the slit, and the two-dispersion phase parallel continuous flows are sheared at the second connection sites, whereby two-phase droplets, and in particular, core-shell or Janus two-phase droplets, can be generated, and a product can be collected from a discharge port.

公开(公告)号：US20240269630A1

公开(公告)日：2024-08-15

申请号：US18681077

申请日：2022-08-11

申请人： Academia Sinica

发明人： Yi-Chung TUNG ,  Dao-Ming CHANG ,  Wei-Hao LIAO ,  Ping-Liang KO

IPC分类号： B01F33/3012 ,  B01F25/314 ,  B01F25/433

CPC分类号： B01F33/3012 ,  B01F25/3141 ,  B01F25/31424 ,  B01F25/4331

摘要： Disclosed herein is a microfluidic mixer comprising first and second input chambers, first and second flow paths, and an output chamber. According to embodiments of the present disclosure, the first input chamber and the output chamber respectively have their bottom surfaces leveled with that of the first and/or second flow paths, while the second input chamber has its bottom surface protruded below that of the first flow path. Also disclosed herein is a microfluidic system comprising the present microfluidic mixer, and a pump for introducing a first and a second fluid reactants respectively into the first and a second input chambers.

公开(公告)号：US11975298B2

公开(公告)日：2024-05-07

申请号：US17249358

申请日：2021-02-26

申请人： KABUSHIKI KAISHA TOSHIBA

发明人： Mitsuaki Kato ,  Masato Akita ,  Hideaki Okano

IPC分类号： B01F33/3012 ,  B01F33/301

CPC分类号： B01F33/3017 ,  B01F33/3012 ,  B01F2215/0409 ,  B01F2215/0431

摘要： According to one embodiment, a fluid controller includes a fluid channel deforming portion and a mixing portion provided downstream from the fluid channel deforming portion. The fluid channel deforming portion includes an upstream end portion, a first channel, a second channel and a channel terminating portion. At least one of the first and second channels is deformed between the upstream end portion and the channel terminating portion. A region of the second channel in a second cross-section, is increased more than a region of the second channel in the first cross-section, between the upstream end portion ad the channel terminating portion. The mixing portion mixes a plurality of fluids flowing through the fluid channel deforming portion.

公开(公告)号：US11724241B2

公开(公告)日：2023-08-15

申请号：US16966511

申请日：2019-02-15

申请人： Cambridge Enterprise Limited

发明人： Nicholas Jose ,  Alexei Lapkin

IPC分类号： B01J10/02 ,  B01J19/24 ,  B01J19/00 ,  C07F1/08 ,  B01F23/232 ,  B01F33/3012 ,  B01J14/00 ,  B01F101/00

CPC分类号： B01J10/02 ,  B01F23/232 ,  B01F33/30121 ,  B01J14/00 ,  B01J19/0006 ,  B01J19/2415 ,  C07F1/08 ,  B01F2101/2204 ,  B01J19/244 ,  B01J2219/00033 ,  B01J2219/00164 ,  C07B2200/09 ,  C07B2200/13

摘要： Disclosed herein is a constant shear continuous reactor device, comprising: an annular gas delivery tube comprising a gas inlet and a gas outlet; a first annular liquid delivery tube comprising a first liquid inlet and a first liquid outlet arranged concentrically around the annular gas delivery tube along a common axis, where the first liquid outlet is located at a downstream position relative to the gas outlet or is coterminous with the gas outlet; and an annular reactor wall tube comprising a final liquid inlet, a mixing zone section and a reactor outlet, where the annular reactor wall tube is arranged concentrically around the first annular liquid delivery tube along the common axis.

公开(公告)号：US20230142172A1

公开(公告)日：2023-05-11

申请号：US17911096

申请日：2021-03-12

申请人： Japan Science and Technology Agency

发明人： Takasi NISISAKO

IPC分类号： B01F33/3012 ,  B01F33/30 ,  B01F33/3011 ,  B01F35/00 ,  B01F25/314 ,  B01F23/41 ,  B01F23/232 ,  B81B1/00

CPC分类号： B01F33/3012 ,  B01F33/30351 ,  B01F33/3011 ,  B01F35/561 ,  B01F25/31432 ,  B01F23/4143 ,  B01F23/2323 ,  B81B1/006 ,  B01F2215/0431 ,  B81B2201/057 ,  B81B2203/0338

摘要： A microdroplet/bubble-generating device comprising a slit and a row of a plurality of microflow paths is constructed, in such a manner that either a continuous phase or dispersion phase is supplied to the slit, and so that the end of the slit, the other supply port for the continuous phase or dispersion phase and the liquid recovery port are connected. The plurality of microflow paths each have a narrow part where the cross-sectional area of the flow channel is locally narrowed adjacent to or near the connection point between the slit and the microflow path. The continuous phase and dispersion phase that have met at the connection points flow into the narrow parts, and the dispersion phase is sheared at the narrow parts with the continuous phase flow as the driving force, forming droplets or gas bubbles of the dispersion phase. The product is recovered from the liquid recovery port.