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公开(公告)号：US20230330673A1
公开(公告)日：2023-10-19
申请号：US17721650
申请日：2022-04-15
发明人： Oumnia El Fajri , Richard W. SEAVER , Erik D. TORNIAINEN , Anand Samuel JEBAKUMAR , Pavel KORNILOVICH , Alexander GOVYADINOV , Carson DENISON
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L3/50273 , B01L2200/12 , B01L2200/16 , B01L2400/0406 , B01L2300/12
摘要： An example microfluidic structure can include a first microfluidic channel segment in a first elevation plane, a second microfluidic channel segment in a second elevation plane, and a transverse microfluidic channel segment connecting the first microfluidic channel segment to the second microfluidic channel segment. An angled exterior wall segment can be at the transverse microfluidic channel segment. The angled exterior wall segment can be angled in the first or second elevation plane at an acute angle with respect to a direction of fluid flow through the first or second microfluidic channel segment. A fluid cross-sectional area can increase in the fluid flow direction along the angled exterior wall segment.
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公开(公告)号：US20230140317A1
公开(公告)日：2023-05-04
申请号：US17912723
申请日：2020-04-23
摘要： An example method for measuring deformability of a cell, consistent with the present disclosure, includes detecting a single cell of a biologic sample in a cell probing chamber of a microfluidic device. The method includes isolating the cell in the cell probing chamber of the microfluidic device by terminating the flow of the biologic sample through the microfluidic device. The method further includes causing deformation of the cell by introducing ultrasonic waves into the cell probing chamber, and measuring deformability of the cell responsive to the introduction of the ultrasonic waves.
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公开(公告)号：US20190001335A1
公开(公告)日：2019-01-03
申请号：US15748975
申请日：2016-01-08
摘要： Examples include polymerase chain reaction (PCR) devices. Example PCR devices comprise a fluid input, ejection nozzles, and a set of microfluidic channels that fluidly connect the fluid input and the ejection nozzles. Each microfluidic channel comprises a reaction chamber, and examples further comprise at least one heating element, where the at least one heating element is positioned in the reaction chamber of each microfluidic channel. The at least one heating element is to heat fluid in the reaction chamber of each fluid channel. The device may eject fluid via the ejection nozzles.
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公开(公告)号：US20170246867A1
公开(公告)日：2017-08-31
申请号：US15521848
申请日：2014-10-31
发明人： Alexander GOVYADINOV , Chris BAKKER
CPC分类号： B41J2/14137 , B41J2/045 , B41J2/04508 , B41J2/04548 , B41J2/04573 , B41J2/04581 , B41J2/135 , B41J2/1404 , B41J2/14056 , B41J2002/14467 , B41J2202/12
摘要： A fluid ejection device includes a fluid slot, a plurality of fluid ejection chambers communicated with the fluid slot, a plurality of drop ejecting elements one of each within one of the fluid ejection chambers, a plurality of fluid circulation channels each communicated with the fluid slot and one or more of the fluid ejection chambers, and a plurality of fluid circulating elements each communicated with one or more of the fluid circulation channels. The fluid circulating elements are to provide intermittent circulation of fluid from the fluid slot through the one or more of the fluid circulation channels and the one or more of the fluid ejection chambers.
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公开(公告)号：US20230381723A1
公开(公告)日：2023-11-30
申请号：US17826943
申请日：2022-05-27
发明人： Carson Denison , Richard W. SEAVER , Erik D. TORNIAINEN , Pavel KORNILOVICH , Alexander GOVYADINOV , Anand Samuel JEBAKUMAR , Oumnia EL FAJRI
IPC分类号： B01F33/3012 , B01F35/71
CPC分类号： B01F33/3012 , B01F35/7172 , B01F2101/2204
摘要： An example microfluidic mixer can include an inlet microfluidic channel portion and a fluid splitting channel portion including an overpass microfluidic channel to receive fluid from a first side of the inlet microfluidic channel portion and an underpass microfluidic channel to receive fluid from a second side of the inlet microfluidic channel portion, where the underpass microfluidic channel extends under the overpass microfluidic channel such that the channels overlap at their respective downstream ends. A fluid recombining channel portion is downstream of the fluid splitting portion and includes an angled recombining surface having an acute angle with respect to a direction of fluid flow, where the angled recombining surface is between the downstream ends of the overpass and underpass microfluidic channels. An outlet microfluidic channel portion is fluidly connected downstream from the fluid recombining channel portion.
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6.发明公开公开(公告)号：US20230285970A1
公开(公告)日：2023-09-14
申请号：US17692589
申请日：2022-03-11
CPC分类号： B01L3/502761 , C12Q3/00 , G01N21/6428 , B01L2200/025 , B01L2200/027 , B01L2200/0652 , B01L2200/16 , B01L2300/0654 , B01L2400/02 , G01N2021/6439
摘要： An example apparatus comprises a first microfluidic channel fluidically coupled to a first reservoir containing a carrier fluid, the first microfluidic channel including a reaction region, a fluid droplet generator, and a fluid ejector fluidically coupled to the first microfluidic channel and disposed downstream from the reaction region of the first microfluidic channel. The fluid droplet generator includes a portion of the first microfluidic channel and a second microfluidic channel that intersects the first microfluidic channel and is fluidically coupled to a second reservoir containing a reaction fluid, where the reaction fluid including a plurality of cells and fluorescently-labeled capture reagents to form reaction products with a target molecule secreted by the plurality of cells.
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公开(公告)号：US20230011683A1
公开(公告)日：2023-01-12
申请号：US17782601
申请日：2020-01-23
摘要： An example apparatus comprises a thermal cell lysis chamber, including a substrate and a lid coupled to the substrate to form a microfluidic channel therethrough. The apparatus includes cell detection circuitry to detect presence of a cell within the microfluidic channel and to detect lysis of the cell. The apparatus also includes a thermal lysing element disposed in the lid to apply heat to a cell detected by the cell detection circuitry, and lysis control circuitry. The lysis control circuitry is to regulate a temperature applied by the thermal lysing element, based on detection by the cell detection circuitry of a cell within the microfluidic channel and based on detection by the cell detection circuitry of a lysis event, and record the temperature applied by the thermal lysing element at which the lysis event occurred.
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公开(公告)号：US20220032298A1
公开(公告)日：2022-02-03
申请号：US17297219
申请日：2019-02-01
摘要： In one example in accordance with the present disclosure, a cell sorting device is described. The cell sorting device includes a microfluidic channel to serially transport individual cells from a volume of cells along a flow path. A sensor disposed in the microfluidic channel distinguishes between a cell to be analyzed and waste fluid. The cell sorting device includes at least two fluid transport devices disposed within the microfluidic channel. The at least two fluid transport devices include a cell ejector to, responsive to detection of a cell to be analyzed, eject the cell to be analyzed from the cell sorting device and a waste transport device to direct the waste fluid to a waste reservoir.
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公开(公告)号：US20210331152A1
公开(公告)日：2021-10-28
申请号：US16608289
申请日：2018-07-17
摘要： An example device includes a droplet ejector including a nozzle to eject droplets of a fluid and a target medium to receive the droplets of the fluid. The target medium is separated from the droplet ejector by a gap to be traversed by the droplets. The example device further includes a frame affixing the target medium to the droplet ejector. The target medium is immovably held with respect to the droplet ejector.
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公开(公告)号：US20210060548A1
公开(公告)日：2021-03-04
申请号：US16643954
申请日：2017-11-22
摘要： The present disclosure is drawn to temperature-cycling microfluidic devices. In one example, a temperature-cycling microfluidic device can include a driver chip having a top surface and a heat exchange substrate having a top surface coplanar with the top surface of the driver chip. A fluid chamber can be located on the top surface of the driver chip. A first and second microfluidic loop can have fluid driving ends and fluid outlet ends connected to the fluid chamber and can include portions thereof located on the top surface of the heat exchange substrate. A first and second fluid actuator can be on the driver chip. The first and second fluid actuators can be associated with the fluid driving ends of the first and second microfluidic loops, respectively, to circulate fluid through the first and second microfluidic loops.
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