公开(公告)号：US20220081667A1

公开(公告)日：2022-03-17

申请号：US17420040

申请日：2019-01-18

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Milo Overbay ,  Viktor Shkolnikov

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/36

Abstract: Blood being circulated to mimic the environment it naturally inhabits increases growth of cultures including bacteria for analysis. The present disclosure presents examples of a device, method, computer-readable medium, and other techniques for simulating a natural environment for blood. The techniques may include a channel with a hydrophobic interior surface and a fluid mover to encourage continuous fluid flow through the channel. The techniques may further include a gas exchange opening of the channel that exposes a fluid to gas outside of the channel.

公开(公告)号：US11199499B2

公开(公告)日：2021-12-14

申请号：US16076345

申请日：2017-07-20

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Milo Overbay ,  Anita Rogacs ,  Devin A. Mourey

IPC: G01N21/64 ,  G01J3/44 ,  G01N21/65

Abstract: A surface enhanced luminescence analyte interrogation stage may include a substrate and an array of pillars projecting from the substrate. Each of the pillars may include a polymeric post formed from a first material and a cap on the polymeric post. The cap has a plasmonic surface and is formed from a second material different than the first. A sacrificial coating covers the cap of each of the pillars.

公开(公告)号：US11320379B2

公开(公告)日：2022-05-03

申请号：US16074331

申请日：2016-04-21

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Milo Overbay ,  James Abbott ,  Anita Rogacs ,  Viktor Shkolnikov

IPC: G01N21/64 ,  B82Y15/00 ,  B82Y40/00 ,  G01N21/65 ,  B05D5/08 ,  B82Y30/00 ,  C23C16/44 ,  C23C16/455 ,  C23C16/50

Abstract: A surface enhanced luminescence (SELS) sensor may include a substrate and nano fingers projecting from the substrate. Each of the nano fingers may include a polymer pillar having a sidewall and a top, a coating layer covering the sidewall and a metal cap supported by and in contact with the top of the pillar.

公开(公告)号：US20210214663A1

公开(公告)日：2021-07-15

申请号：US17047349

申请日：2018-08-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Fausto D'Apuzzo ,  Caitlin DeJong ,  Milo Overbay

IPC: C12M1/32 ,  C12M1/26 ,  G01N21/3577 ,  C12Q1/18 ,  C12M3/06

Abstract: An example of an apparatus includes a plurality of wells, wherein each well is to receive a cell culture and a cell culture liquid. The apparatus also includes a collector to contact the cell culture liquid in a well selected from the plurality of wells. The collector is to draw a microfluidic sample of the cell culture liquid from the well. In addition, the apparatus includes a sensor substrate to receive the microfluidic sample, wherein the sensor substrate is to be used to measure a characteristic of the cell culture liquid. Also, the apparatus includes a microfluidic channel to transport the microfluidic sample from the collector to the sensor substrate.

公开(公告)号：US20210190687A1

公开(公告)日：2021-06-24

申请号：US16074331

申请日：2016-04-21

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Milo Overbay ,  James Abbott ,  Anita Rogacs ,  Viktor Shkolnikov

IPC: G01N21/64 ,  G01N21/65

Abstract: A surface enhanced luminescence (SELS) sensor may include a substrate and nano fingers projecting from the substrate. Each of the nano fingers may include a polymer pillar having a sidewall and a top, a coating layer covering the sidewall and a metal cap supported by and in contact with the top of the pillar.

公开(公告)号：US11255792B2

公开(公告)日：2022-02-22

申请号：US16098058

申请日：2016-07-21

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Anita Rogacs ,  Steven J. Simske ,  Milo Overbay ,  Viktor Shkolnikov

IPC: G01N21/65 ,  B82Y15/00 ,  B82Y30/00 ,  G01J3/44

Abstract: A surface enhanced Raman spectroscopy (SERS) sensor may include a nano structured surface and a nonstoichiometric oxide layer. The nano structured surfers may include a first peak, a second peak and a valley between the first peak and the second peak. The non-stoichiometric oxide layer may include a first portion on the first peak and a second portion on the second peak.

公开(公告)号：US10828637B2

公开(公告)日：2020-11-10

申请号：US15792732

申请日：2017-10-24

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Viktor Shkolnikov ,  Milo Overbay

IPC: B01L3/00 ,  G01N21/64 ,  B29C39/00 ,  B01L9/00 ,  A61K49/00 ,  G01N21/65

Abstract: A microfluidic chip may include a substrate, chamber supported by the substrate, a sacrificial material in the chamber, a spectroscopically active nano particle assembly anchored within the chamber by the sacrificial material and a fluid supply port connected to the chamber. Each spectroscopically active nano particle assembly may include a cluster of nanoparticles.

公开(公告)号：US20190170650A1

公开(公告)日：2019-06-06

申请号：US16098058

申请日：2016-07-21

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Anita Rogacs ,  Steven J. Simske ,  Milo Overbay ,  Viktor Shkolnikov

IPC: G01N21/65

Abstract: A surface enhanced Raman spectroscopy (SERS) sensor may include a nano structured surface and a nonstoichiometric oxide layer. The nano structured surfers may include a first peak, a second peak and a valley between the first peak and the second peak. The non-stoichiometric oxide layer may include a first portion on the first peak and a second portion on the second peak.

公开(公告)号：US11169091B2

公开(公告)日：2021-11-09

申请号：US16082399

申请日：2017-07-20

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Christopher N. Young ,  Milo Overbay ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N1/10 ,  G01N21/552 ,  G01N21/64 ,  G01N21/65

Abstract: A surfaced enhanced luminescence analyte interrogation stage shipping and storage package may include a sealed chamber, a liquid contained within the sealed chamber and nano pillars within the sealed chamber and submersed within the liquid. The nano pillars comprise polymer posts and metallic caps forming tips of the nano pillars.

公开(公告)号：US20210163866A1

公开(公告)日：2021-06-03

申请号：US17047336

申请日：2018-08-21

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Fausto D'Apuzzo ,  Kendra Dee Nyberg ,  Milo Overbay

IPC: C12M3/06 ,  G01N15/02 ,  G01N15/06 ,  G01N15/14

Abstract: An example of an apparatus includes an inlet to receive a plurality of cells suspended in a solution. The apparatus also includes a microfluidic channel to transport the plurality of cells suspended in the solution. In addition, the apparatus includes a trap disposed along the microfluidic channel, wherein the trap is to isolate the plurality of cells suspended in the solution. Also, the apparatus includes a buffer supply to dispense a buffer to wash the plurality of cells and to remove the solution from the microfluidic channel. The apparatus further includes a sensor to measure a characteristic of the plurality of cells after isolated from the solution.