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公开(公告)号：US20230250378A1
公开(公告)日：2023-08-10
申请号：US18012613
申请日：2020-07-08
CPC分类号： C12M23/16 , C12M35/04 , C12M41/40 , G01N15/1463 , G01N15/1459 , G01N2015/1495 , G01N2015/1006
摘要： An example method for measuring deformability of a cell responsive to a pressure wave, consistent with the present disclosure, includes moving a cell of a sample into a cell probing chamber of a microfluidic device. While the cell is in the cell probing chamber, the method includes generating a pressure wave within the cell probing chamber by actuating a fluidic pump. The method further includes determining a deformability of the cell responsive to the pressure wave, using an imaging array synchronized with the actuation of the fluidic pump.
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公开(公告)号：US20210252499A1
公开(公告)日：2021-08-19
申请号：US17054675
申请日：2018-10-11
IPC分类号： B01L3/02
摘要： In one example, an apparatus includes a surface-enhanced substrate having a microdot deposited onto a surface thereon via a microfluidic ejector. The microdot includes a predetermined concentration of an analyte.
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公开(公告)号：US20210163866A1
公开(公告)日：2021-06-03
申请号：US17047336
申请日：2018-08-21
摘要： An example of an apparatus includes an inlet to receive a plurality of cells suspended in a solution. The apparatus also includes a microfluidic channel to transport the plurality of cells suspended in the solution. In addition, the apparatus includes a trap disposed along the microfluidic channel, wherein the trap is to isolate the plurality of cells suspended in the solution. Also, the apparatus includes a buffer supply to dispense a buffer to wash the plurality of cells and to remove the solution from the microfluidic channel. The apparatus further includes a sensor to measure a characteristic of the plurality of cells after isolated from the solution.
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公开(公告)号：US12032147B2
公开(公告)日：2024-07-09
申请号：US17255808
申请日：2018-10-01
发明人： Fausto D'Apuzzo , Viktor Shkolnikov
IPC分类号： G02B21/12 , G01N15/0227 , G01N15/10 , G01N15/14 , G01N15/1433 , G01N15/1434 , G02B21/00 , G02B21/36
CPC分类号： G02B21/12 , G01N15/0227 , G01N15/1433 , G01N15/1434 , G01N15/1459 , G02B21/0004 , G02B21/36 , G01N2015/1006 , G01N2015/1493
摘要： A system and a method for imaging microfluidic ejectors during operation. An example provides a microscopy system, that includes a plurality of microfluidic ejectors. A mirror is disposed in a droplet path of the plurality of microfluidic ejectors, wherein the droplet path passes through an opening in the mirror. An optical system is focused on the plurality of microfluidic ejectors through the mirror, wherein the optical system comprises a camera.
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公开(公告)号：US11486814B2
公开(公告)日：2022-11-01
申请号：US17255761
申请日：2018-10-01
发明人： Fausto D'Apuzzo , Viktor Shkolnikov , Yang Lei
摘要： A system and a method for sorting particles are provided. An example of a particle sorting system includes an array that includes a number of microfluidic ejectors. An optical sensor is focused on the array. A controller is used to identify a target particle proximate to a microfluidic ejector, and activate the microfluidic ejector to eject the target particle into a collection vessel.
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公开(公告)号：US20220082504A1
公开(公告)日：2022-03-17
申请号：US17415203
申请日：2019-06-04
发明人： Fausto D'Apuzzo , Steven Barcelo , Anita Rogacs
摘要： Systems and methods for generating calibration curve for a sensor are provided. An example method includes printing at least two spots of an analyte on the sensor, wherein each of the spots includes a different number of overprinted droplets ejected from a single printhead.
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公开(公告)号：US11932844B2
公开(公告)日：2024-03-19
申请号：US17256333
申请日：2018-10-09
发明人： Fausto D'Apuzzo , Anita Rogacs
CPC分类号： C12M41/36 , G02B1/002 , G02B1/06 , G02B21/0004 , G02B21/06 , G02B21/364 , G02B21/365 , G06V20/693 , G02B2207/101
摘要： An example apparatus includes a sampling layer to position microscopic objects thereon, a light encoding layer to encode light from passing through the microscopic objects of the sampling layer, the light encoding layer having a substantially flat form, and an imaging layer to capture an image of the sampling layer, the image being encoded by the light encoding layer.
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公开(公告)号：US11543356B2
公开(公告)日：2023-01-03
申请号：US17256681
申请日：2018-10-29
发明人： Viktor Shkolnikov , Fausto D'Apuzzo , Yang Lei
摘要： An example apparatus includes a well plate having an array of wells, a light encoding layer positioned under the well plate, an imaging layer to capture an image of the well plate encoded by the light encoding layer, an array of electrodes positioned on a surface of a bottom floor of the at least one well, and a controller. The light encoding layer is to encode light passing through a microscopic object in at least one well of the array of wells. The light encoding layer has a substantially flat form. The controller is to direct electrical voltage to the electrodes to generate a non-rotating, non-uniform electrical field, the electrical field being to rotate an object in the electrical field.
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公开(公告)号：US20210262937A1
公开(公告)日：2021-08-26
申请号：US17256681
申请日：2018-10-29
发明人： Viktor Shkolnikov , Fausto D'Apuzzo , Yang Lei
摘要： An example apparatus includes a well plate having an array of wells, a light encoding layer positioned under the well plate, an imaging layer to capture an image of the well plate encoded by the light encoding layer, an array of electrodes positioned on a surface of a bottom floor of the at least one well, and a controller. The light encoding layer is to encode light passing through a microscopic object in at least one well of the array of wells. The light encoding layer has a substantially flat form. The controller is to direct electrical voltage to the electrodes to generate a non-rotating, non-uniform electrical field, the electrical field being to rotate an object in the electrical field.
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公开(公告)号：US20210214663A1
公开(公告)日：2021-07-15
申请号：US17047349
申请日：2018-08-20
发明人： Steven Barcelo , Anita Rogacs , Fausto D'Apuzzo , Caitlin DeJong , Milo Overbay
IPC分类号： C12M1/32 , C12M1/26 , G01N21/3577 , C12Q1/18 , C12M3/06
摘要： An example of an apparatus includes a plurality of wells, wherein each well is to receive a cell culture and a cell culture liquid. The apparatus also includes a collector to contact the cell culture liquid in a well selected from the plurality of wells. The collector is to draw a microfluidic sample of the cell culture liquid from the well. In addition, the apparatus includes a sensor substrate to receive the microfluidic sample, wherein the sensor substrate is to be used to measure a characteristic of the cell culture liquid. Also, the apparatus includes a microfluidic channel to transport the microfluidic sample from the collector to the sensor substrate.
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