公开(公告)号：US20220117906A1

公开(公告)日：2022-04-21

申请号：US17431303

申请日：2020-01-23

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Ryo Tanaka ,  Kazuya Kominami ,  Naoyuki Uchida ,  Takito Shima

IPC: A61K9/70 ,  A61K47/32

Abstract: The problem addressed by the present invention is to provide a method for suppressing cold flow during packaging or application, regardless of the properties or concentration of a drug, in a patch containing a drug and an acrylic adhesive base in an adhesive layer. The present invention relates to a method for suppressing cold flow of a patch equipped with a support layer and an adhesive layer containing a drug and an acrylic adhesive base, wherein the method causes calcium silicate to be contained in the adhesive layer.

公开(公告)号：US10898448B2

公开(公告)日：2021-01-26

申请号：US16604311

申请日：2018-04-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takito Shima ,  Toshiyuki Matsudo ,  Kenji Ishigaki

IPC: A61K9/70 ,  A61K31/485 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34

Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains an adhesive base and an antioxidant containing a sulfur atom in its molecule.

公开(公告)号：US12178922B2

公开(公告)日：2024-12-31

申请号：US17244552

申请日：2021-04-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo Tanaka ,  Hideaki Ohashi ,  Naruhide Miyoshi ,  Takito Shima ,  Naoko Fujita ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US10888532B2

公开(公告)日：2021-01-12

申请号：US16471692

申请日：2017-12-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoko Fujita ,  Takito Shima ,  Kazuya Kominami ,  Naoyuki Uchida

IPC: A61K9/70 ,  A61K31/485 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains at least one drug selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof and a silicone-based adhesive base, and a mass per unit area of the adhesive layer is 30 to 90 g/m2.

公开(公告)号：US11364207B2

公开(公告)日：2022-06-21

申请号：US16483511

申请日：2018-02-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Hideaki Ohashi ,  Takito Shima ,  Kenji Ishigaki ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/4045 ,  A61K47/02

Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.

公开(公告)号：US11202764B2

公开(公告)日：2021-12-21

申请号：US16605268

申请日：2018-04-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya Kominami ,  Takito Shima ,  Naoyuki Uchida ,  Naoko Fujita ,  Shigeo Suzuki ,  Terumitsu Kaiho

IPC: A61K9/70 ,  A61K47/12 ,  A61P25/04 ,  A61K31/485

Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

公开(公告)号：US11020356B2

公开(公告)日：2021-06-01

申请号：US16474213

申请日：2017-12-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo Tanaka ,  Hideaki Ohashi ,  Naruhide Miyoshi ,  Takito Shima ,  Naoko Fujita ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.