公开(公告)号：US10898448B2

公开(公告)日：2021-01-26

申请号：US16604311

申请日：2018-04-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Takito Shima ,  Toshiyuki Matsudo ,  Kenji Ishigaki

IPC分类号： A61K9/70 ,  A61K31/485 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34

摘要： A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains an adhesive base and an antioxidant containing a sulfur atom in its molecule.

公开(公告)号：US11116955B2

公开(公告)日：2021-09-14

申请号：US16488450

申请日：2018-02-20

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Toru Kobayashi ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Tetsuji Kuwahara

IPC分类号： A61M37/00

摘要： A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

公开(公告)号：US20150157840A1

公开(公告)日：2015-06-11

申请号：US14407258

申请日：2013-06-11

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Kazuya Kominami ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Makoto Ogura ,  Toshiyuki Matsudo ,  Naoki Yamamoto

IPC分类号： A61M37/00 ,  A61N2/00 ,  A61N1/32

CPC分类号： A61M37/0015 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61N1/325 ,  A61N2/002 ,  A61N2/004

摘要： A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.

摘要翻译： 根据一个实施方案的微针片包括形成在基本上沿着片材的主表面的片材上的多个微针。 弯曲片从主表面抬起微针，凸起的微针刺穿皮肤。

公开(公告)号：US11130148B2

公开(公告)日：2021-09-28

申请号：US14894397

申请日：2014-05-29

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Eiji Hashimoto ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto

IPC分类号： B05C15/00 ,  F24F3/16 ,  F24F3/14 ,  B05C21/00 ,  B05C3/00 ,  B81C99/00 ,  A61M37/00 ,  F24F8/10 ,  B05D3/04

摘要： The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

公开(公告)号：US11077290B2

公开(公告)日：2021-08-03

申请号：US16488450

申请日：2018-02-20

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Toru Kobayashi ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Tetsuji Kuwahara

IPC分类号： A61M37/00

摘要： A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.