公开(公告)号：US11130985B2

公开(公告)日：2021-09-28

申请号：US15529122

申请日：2015-10-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Naoshi Itabashi ,  Sonoko Migitaka ,  Masatoshi Narahara ,  Tomohiro Shoji ,  Yukio Ono

IPC: C12Q1/68 ,  C12Q1/6809 ,  B01J19/00 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N35/00 ,  G01N35/10 ,  B32B27/32 ,  C08G77/50

Abstract: In order to reduce the cost of producing a spot array substrate and reduce the cost of nucleic acid polymer analysis, a spot array substrate is used which is produced by preparing a resin substrate 402 having a surface on which an uneven pattern is formed and a plurality of bead sitting positions set in a two-dimensional array within the uneven pattern, and loading surface-modified beads onto the bead sitting positions of the resin substrate.

公开(公告)号：US11181502B2

公开(公告)日：2021-11-23

申请号：US15129854

申请日：2015-03-26

Applicant: Hitachi High-Technologies Corporation

Inventor： Naoshi Itabashi ,  Sonoko Migitaka ,  Itaru Yanagi ,  Rena Akahori ,  Kenichi Takeda

IPC: G01N21/63 ,  G01N27/00 ,  G01N27/92 ,  G01N27/447 ,  G01N21/64 ,  G01N21/65 ,  G01N33/487 ,  B82Y40/00

Abstract: While an insulating film having a near-field light generating element placed thereon is being irradiated with light in an electrolytic solution, or after the film that has been irradiated with light is disposed in the electrolytic solution, a first voltage is applied between the two electrodes installed in the electrolytic solution across the film, a second voltage is then applied between the two electrodes, and a value of a current that flows between the two electrodes due to the application of the second voltage is detected. This procedure is stopped when the current value reaches or exceeds a pre-set threshold value, whereby a hole is formed at a desired location in the thin-film.

公开(公告)号：US10451584B2

公开(公告)日：2019-10-22

申请号：US14759596

申请日：2013-11-18

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yoshimitsu Yanagawa ,  Takahide Yokoi ,  Naoshi Itabashi ,  Takayuki Kawahara ,  Sonoko Migitaka ,  Makiko Yoshida ,  Takamichi Muramatsu

IPC: G01N27/414

Abstract: Provided is a biomolecule measuring device capable of effectively reducing measurement noise occurring when measuring a biomolecule sample using a semiconductor sensor. This biomolecule measuring device generates a trigger to react a sample with a reagent after starting to send the reagent onto the semiconductor sensor that detects ion concentration (see FIG. 7).