公开(公告)号：US20180037930A1

公开(公告)日：2018-02-08

申请号：US15548574

申请日：2015-02-23

Applicant: Hitachi High-Technologies Corporation

Inventor： Manami NAMMOKU ,  Terumi TAMURA ,  Kohshi MAEDA ,  Daisuke MORISHIMA ,  Toshinari SAKURAI ,  Wataru SATO

IPC: C12Q1/68 ,  B01L7/00

Abstract: The purpose of the invention is to provide a nucleic acid analyzer that sets and executes temperature regulation, said temperature regulation matching the characteristics of analyzing items and the configuration of the analyzer, by a simple operation while preventing deterioration in analytical performance caused by partial overheating of a liquid reaction mixture to thereby improve temperature change speed and shorten analysis time. To achieve the above purpose, provided is a method wherein, in the case of performing overshooting: as a first processing, the temperature is continuously elevated until reaching a target overshoot temperature; as a second processing, after reaching the aforesaid temperature, the overshoot target temperature is maintained for a preset period of time; and, as a third processing, the temperature is continuously lowered until reaching a target temperature of the liquid reaction mixture. By executing the first to third processings, regulation is conducted so that temperature measurement values are in a trapezoidal form.

公开(公告)号：US20180245031A1

公开(公告)日：2018-08-30

申请号：US15758509

申请日：2016-07-27

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Wataru SATO ,  Nobuyuki ISOSHIMA ,  Kohshi MAEDA ,  Daisuke MORISHIMA

IPC: C12M1/38 ,  C12M1/36 ,  C12M1/34

CPC classification number: C12M1/38 ,  B01L3/5082 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/1822 ,  C12M1/00 ,  C12M41/12 ,  C12M41/48 ,  F25B21/04 ,  F25B2500/19

Abstract: Provided is a highly reliable temperature adjustment apparatus which uses a temperature adjustment element and quantitatively evaluates the temperature adjustment performance of the temperature adjustment element. The temperature adjustment apparatus is provided with: a temperature adjustment element; one or more temperature detection elements provided near the temperature adjustment element; a calculation unit for calculating the output of the temperature detection element; and a display unit for displaying at least one of a time calculated by the calculation unit as a time at which the temperature adjustment performance of the temperature adjustment is predicted to be below a desired level, the number of operations and the time of current conduction or a warning based on the result of calculation.

公开(公告)号：US20180313813A1

公开(公告)日：2018-11-01

申请号：US15772196

申请日：2015-11-24

Applicant: Hitachi High-Technologies Corporation

Inventor： Michiru FUJIOKA ,  Nobuyuki ISOSHIMA ,  Wataru SATO

IPC: G01N33/487 ,  C12Q1/6816

CPC classification number: C12Q1/68 ,  G01N33/48721

Abstract: A biological sample analyzer using a nanopore, said analyzer comprising: a first chamber that storing a solvent; a baseboard provided with a nanopore through which a biological sample passes; a second chamber which is positioned adjacently to the first chamber via the baseboard and stores the solvent; a first electrode formed in the first chamber; a second electrode formed in the second chamber; a detector detecting the biological sample which has passed through the nanopore; and a stirrer stirring the solvent in the first chamber.

公开(公告)号：US20200057022A1

公开(公告)日：2020-02-20

申请号：US16484696

申请日：2018-03-08

Applicant: Hitachi High-Technologies Corporation

Inventor： Wataru SATO ,  Motohiro YAMAZAKI

IPC: G01N27/447

Abstract: The capillary electrophoresis apparatus according to the present invention can maintain the temperature in the longitudinal direction of each of a plurality of capillaries uniformly, such that the separation performance of the capillary electrophoresis apparatus can be stabilized, and the analysis performance can be improved. A capillary electrophoresis apparatus according to the present invention includes: a thermostat having a heat source, a first heat conduction member, and a detection window for detecting a sample, the thermostat being configured to maintain a capillary at a predetermined temperature; a capillary holder having a second heat conduction member for sandwiching the capillary between the second heat conduction member and the first heat conduction member, the capillary holder being configured to hold the capillary; and a detection unit configured to detect a sample to be electrophoresed in the capillary, wherein in the heat source, a heat generation amount of at least one of a periphery of the detection window and an end of the capillary is higher than a heat generation amount of another portion.