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    Benzene sulfonyl-urea preparation for treatment of diabetes mellitus and a method for treatment
    3.
    发明授权
    Benzene sulfonyl-urea preparation for treatment of diabetes mellitus and a method for treatment 失效
    用于治疗糖尿病的苯磺酰脲制剂及其治疗方法

    公开(公告)号：US3928610A

    公开(公告)日：1975-12-23

    申请号：US32483473

    申请日：1973-01-18

    申请人： HOECHST AG

    发明人： WEYER RUDY ,  AUMULLER WALTER ,  WEBER HELMUT ,  SCHWEITZER ROLAND ,  HEERDT RUTH

    IPC分类号： C07D215/48 ,  A61K27/00

    CPC分类号： C07D215/48 ,  Y10S514/884

    摘要： Hypoglycemically active benzenesulfonyl-ureas of the formula

    WHEREIN X is hydrogen, chlorine, bromine, methoxy or methyl, Y is -CH(CH3)-CH2, -CH2-CH(CH3)-or -CH2CH2-, R is alkyl of 3 to 6 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, which may be substituted by 1 or 2 alkyl of up to 3 carbon atoms or by chlorine, cycloalkenyl of 5 to 8 carbon atoms, which may be substituted by 1 to 2 alkyl of up to 3 carbon atoms, bicycloalkyl or bicycloalkenyl of 7 or 8 carbon atoms, nortricyclyl, spiro(2,4)-heptyl, Z is hydrogen or a hydrocarbon radical of 1 or 2 carbon atoms which forms with Y a 5- or 6-membered ring, or the salts thereof as a component in a pharmaceutical preparation for oral administration and lowering of the blood sugar level in the treatment of diabetes mellitus and a process for lowering the blood sugar level.

    摘要翻译： 式WHEREIN X的低血糖活性苯磺酰基脲是氢，氯，溴，甲氧基或甲基，Y是-CH（CH3）-CH2，-CH2-CH（CH3） - 或-CH2CH2-，R是3〜 6个碳原子，5至8个碳原子的环烷基，其可以被1或2个最多3个碳原子的烷基取代，或被氯，可以被1至2个烷基取代的5至8个碳原子的环烯基 7个或8个碳原子的双环烷基或双环烯基，nortycycyl，螺[2,4] - 庚基，Z是氢或1或2个碳原子的烃基，与Y形成5-或6-元 环或其盐作为用于口服给药的药物制剂中的组分和降低糖尿病治疗中的血糖水平和降低血糖水平的方法。