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    Intermediates for 5-(4-pyridylethyl)-pyridoindole derivatives
    2.
    发明授权
    Intermediates for 5-(4-pyridylethyl)-pyridoindole derivatives 失效
    5-（4-吡啶基） - 吡啶衍生物的中间体

    公开(公告)号：US3646045A

    公开(公告)日：1972-02-29

    申请号：US3646045D

    申请日：1969-12-08

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERGER LEO ,  CORRAZ ALFRED JOHN

    IPC: C07D471/04 ,  C07D31/42

    CPC classification number: C07D471/04

    Abstract: 5 - (4-PYRIDYLETHYL)-PYRIDOINDOLE DERIVATIVES HAVING ANALGESIC ACTIVITY, PREPARED FROM THE CORRESPONDINGLY SUBSTITUTED 4-PIPERIDONES AND N-AMINO-N-ARYLAMINOETHYLPYRIDINES, ARE DESCRIBED. THE N-AMINO-N-ARYLAMINOETHYLPYRIDINES ARE PREPARED FROM THE SEQUENTIAL INTERMEDIATES NARYLAMINOETHYLPYRIDINES AND'' N-NITROSO-N-ARYLAMINOETHYLPYRIDINES.

    3-Halo-4-oxo-cyclohexane carboxylic acid esters
    5.
    发明授权
    3-Halo-4-oxo-cyclohexane carboxylic acid esters 失效
    3-卤代-4-氧代 - 环己烷羧酸酯

    公开(公告)号：US3903133A

    公开(公告)日：1975-09-02

    申请号：US41832873

    申请日：1973-11-23

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERGER LEO ,  LEIMGRUBER WILLY ,  SCHENKER FAUSTO EUGENIO

    IPC: C07D333/50 ,  C07C69/74

    CPC classification number: C07D333/50

    Abstract: Tricyclic compounds of the formula

    WHEREIN R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, trifluoromethyl, cyano, carbamoyl, carboxy, lower alkoxy carbonyl, nitro, amino, mono-lower alkylamino, dilower alkylamino, acyl, acylamido, sulfamoyl, di-lower alkylsulfamoyl, or difluoromethylsulfonyl; R2 is hydrogen, lower alkyl, amino-lower alkyl, mono-lower alkyl-amino-lower alkyl, or di-lower alkylamino-lower alkyl; n and r are independently 1 or 2; and X is oxygen or sulfur, prepared, inter alia, from the correspondingly substituted phenol or thiophenol and haloketocyclohexane or pentane carboxylic acid ester, are described. The end products are useful as anti-inflammatory and anti-rheumatic agents.

    Abstract translation: 下式的三环化合物，其中R 1为氢，卤素，低级烷基，低级烷氧基，低级烷硫基，三氟甲基，氰基，氨基甲酰基，羧基，低级烷氧基羰基，硝基，氨基，单低级烷基氨基，二低级烷基氨基，酰基，酰基酰氨基 ，氨磺酰基，二低级烷基氨磺酰基或二氟甲基磺酰基; R2是氢，低级烷基，氨基 - 低级烷基，单低级烷基 - 氨基 - 低级烷基或二 - 低级烷基氨基 - 低级烷基; n和r独立地为1或2; 并且X是氧或硫，特别是由相应取代的苯酚或苯硫酚和卤代环己烷或戊烷羧酸酯制备。 最终产品可用作抗炎和抗风湿剂。

    Cycloalkene(B)indoles
    7.
    发明授权
    Cycloalkene(B)indoles 失效
    环烯烃（B）吲哚

    公开(公告)号：US3862953A

    公开(公告)日：1975-01-28

    申请号：US27559872

    申请日：1972-07-27

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERGER LEO ,  CORRAZ ALFRED JOHN

    IPC: C07D213/38 ,  C07D213/42 ,  C07D213/55 ,  C07D213/56 ,  C07D31/40

    CPC classification number: C07D213/42 ,  C07D213/38 ,  C07D213/55 ,  C07D213/56 ,  Y10S514/824

    Abstract: 9-(Pyridylalkyl)-1,2,3,4-tetrahydrocarbazoles and 4(pyridylalkyl)-cyclopenta(b)indoles prepared by reacting the corresponding phenyl hydrazines and cyclohexanones or cyclopentanones, respectively, are described. The products of the invention are useful as antihyperlipidemic agents.

    Abstract translation: 描述了分别通过相应的苯肼和环己酮或环戊酮与反应而制得的9-（吡啶基烷基）-1,2,3,4-四氢咔唑和4-（吡啶基烷基） - 环戊[b]吲哚。 本发明的产品可用作抗高脂血症药。

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