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公开(公告)号：US3657344A
公开(公告)日：1972-04-18
申请号：US3657344D
申请日：1968-10-17
Applicant: HOFFMANN LA ROCHE
Inventor： STEMPEL ARTHUR , STERNBACH LEO HENRYK
IPC: C07C233/00 , C07C233/02 , C07C103/42
CPC classification number: C07C233/00 , C07C233/02 , Y10S514/906
Abstract: 2-AMINOXY-2''-ACYL-ACETANILIDES AND N-N2-AMINO-XPHENYLMETHYLENE) AMINOXYACETIC ACID LOWER ALKYL ESTERS (X=PHENYL, ALKYL AND CYCLOALKYL) AND SUBSTITUTED DERIVACTIVES THEREOF. THESE COMPOUNDS ARE INTERMEDIATES IN THE PREPARATION OF 4,1,5-BENZOXADIAZOCINES (A) AND KNOWN 1,4,BENZODIAZEPINS (B). A AND B ARE USEFUL AS SEDATIVES, MUSCLE RELAXANTS AND ANTICONVULSANT AGETS. A IS ALSO USEFUL AS INTERMEDIATES IN THE PREPARTION F B.
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公开(公告)号：US3453326A
公开(公告)日：1969-07-01
申请号：US3453326D
申请日：1967-03-24
Applicant: HOFFMANN LA ROCHE
Inventor： STEMPEL ARTHUR , STERNBACH LEO HENRYK
IPC: C07D239/76 , C07C131/00
CPC classification number: C07D239/76
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公开(公告)号：US3515756A
公开(公告)日：1970-06-02
申请号：US3515756D
申请日：1968-06-20
Applicant: HOFFMANN LA ROCHE
Inventor： STEMPEL ARTHUR , STERNBACH LEO HENRYK
IPC: A61K31/165 , C07D243/24 , C07C103/42
CPC classification number: C07D243/24 , A61K31/165 , C07D243/28
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4.发明授权Process for the preparation of 1,3-dihydro-2-oxo-5-aryl - 2h - 1,4 benzodiazepines bearing in the 3-position thereof,an esterified carboxy group 失效制备1,3-二氢-2-氧代-5-芳基-2H-1,4苯并二氢吡喃的方法，该3-二氢苯并噻吩在其3-位上具有一个已被鉴定的羧基
公开(公告)号：US3475415A
公开(公告)日：1969-10-28
申请号：US3475415D
申请日：1966-12-05
Applicant: HOFFMANN LA ROCHE
Inventor： HELLERBACH JOSEPH , STEMPEL ARTHUR , STERNBACH LEO HENRYK
IPC: A61K31/55 , C07D243/24 , C07D53/06 , A61K27/00 , C07D57/00
CPC classification number: C07D243/24 , A61K31/55
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5.发明授权
公开(公告)号：US3590049A
公开(公告)日：1971-06-29
申请号：US3590049D
申请日：1968-10-18
Applicant: HOFFMANN LA ROCHE
Inventor： STEMPEL ARTHUR , STERNBACH LEO HENRYK
IPC: C07D209/48 , C07D27/52
CPC classification number: C07D209/48 , Y10S514/906 , Y10S514/937 , Y10S514/96 , Y10S514/962
Abstract: 2''-ACYL-2-AMINOXYACETANILIDE HAVING THE 2-AMINO FUNCTION PROTECTED AND SUBSTITUTED DERIVATIVES THEREOF. THESE COMPOUNDS ARE INTERMEDIATES IN THE PREPARATION OF 4,1,5BENZOXADIAZOCIN-2-ONES (A) WHICH COMPOUNDS ARE CONVERTIBLE INTO 3-HYDROXY-1,4-BENZODIAZEPIN-2-ONES (B). BOTH COMPOUND A AND COMPOUND B ARE ACTIVE AS ANTICONVULSANTS, MUSCLE RELAXANTS AND SEDATIVE AGENTS.
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Patent Agency Ranking
公开(公告)号：US3450695A
公开(公告)日：1969-06-17
申请号：US3450695D
申请日：1967-01-19
Applicant: HOFFMANN LA ROCHE
Inventor： STERNBACH LEO HENRYK , STEMPEL ARTHUR
IPC: A61K31/55 , C07D243/24 , C07D53/06 , A61K27/00
CPC classification number: C07D243/24 , A61K31/55 , Y10S514/906
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公开(公告)号：US3515755A
公开(公告)日：1970-06-02
申请号：US3515755D
申请日：1968-06-18
Applicant: HOFFMANN LA ROCHE
Inventor： STERNBACH LEO HENRYK , STEMPEL ARTHUR
IPC: C07C233/00 , C07C103/42
CPC classification number: C07C233/00
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公开(公告)号：US3453279A
公开(公告)日：1969-07-01
申请号：US3453279D
申请日：1967-03-24
Applicant: HOFFMANN LA ROCHE
Inventor： STEMPEL ARTHUR , STERNBACH LEO HENRYK
IPC: C07D239/76 , C07D53/06
CPC classification number: C07D239/76
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公开(公告)号：US3420817A
公开(公告)日：1969-01-07
申请号：US3420817D
申请日：1966-12-06
Applicant: HOFFMANN LA ROCHE
Inventor： STEMPEL ARTHUR , STERNBACH LEO HENRYK
IPC: C07D209/48 , C07D87/54 , C07C103/30
CPC classification number: C07D209/48 , Y10S514/906
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公开(公告)号：US3657436A
公开(公告)日：1972-04-18
申请号：US3657436D
申请日：1970-02-09
Applicant: HOFFMANN LA ROCHE
Inventor： BERGER LEO , GRUNBERG EMANUEL , STERNBACH LEO HENRYK , STEMPEL ARTHUR
IPC: A61K31/19 , A61K31/535 , A61K27/00
CPC classification number: A61K31/19 , A61K31/535
Abstract: ANTHRANILIC ACID DERIVATIVES WHICH ARE USEFUL IN COMBATTING VIRAL INFECTIONS CAUSED BY COL-SK AND COMPOSITIONS CONTAINING THESE DERIVATIVES.
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