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1.发明申请2'-4'-DIFLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION 有权作为HCV RNA复制的抑制剂的2'-4'-二氟-2'-甲基取代的核苷衍生物公开(公告)号：US20150004135A1
公开(公告)日：2015-01-01
申请号：US14365416
申请日：2012-12-17
发明人： Jing Zhang , Zhuming Zhang
IPC分类号： C07H19/10 , A61K45/06 , A61K31/7072
CPC分类号： C07H19/10 , A61K31/7072 , A61K45/06 , C07H19/06
摘要： The present disclosure relates to compounds of Formula (I): Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of using the compounds of Formula (I) and/or compositions comprising the compounds of Formula (I) for the treatment of HCV.
摘要翻译： 本公开涉及式（I）的化合物：还公开了包含式（I）化合物的药物组合物，使用式（I）化合物和/或包含式（I）化合物的组合物的方法用于治疗 的HCV。
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公开(公告)号：US20160280706A1
公开(公告)日：2016-09-29
申请号：US14778227
申请日：2014-03-31
发明人： Elbert Chin , Robert James Weikert , Weiya Yun , Jing Zhang
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/519 , A61K45/06
摘要： This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
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公开(公告)号：US09617260B2
公开(公告)日：2017-04-11
申请号：US14778227
申请日：2014-03-31
发明人： Elbert Chin , Robert James Weikert , Weiya Yun , Jing Zhang
IPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/519 , A61K45/06
摘要： This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
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公开(公告)号：US20160000760A1
公开(公告)日：2016-01-07
申请号：US14768915
申请日：2014-03-03
发明人： Joseph Anthony Bilotta , Zhi Chen , Feng Chi , Elbert Chin , Qingjie Ding , Shawn David Erickson , Stephen Deems Gabriel , Nan Jiang , Buelent Kocer , Eric Mertz , Jean-Marc Plancher , Robert J. Weikert , Jing Zhang , Qiang Zhang
IPC分类号： A61K31/4196 , A61K31/454 , A61K45/06 , C07D403/12 , C07D249/14 , C07D417/12 , A61K31/428 , A61K31/496 , A61K31/5377 , C07D495/04 , C07D413/12 , A61K31/538 , A61K31/541 , A61K31/5415 , C07D405/12 , C07D491/107 , C07D401/12
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61K45/06 , C07D249/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D491/107 , C07D495/04
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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5.发明申请4'-AZIDO, 3'-FLUORO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION 有权作为HCV RNA复制的抑制剂的4'- AZIDO，3'-氟取代的核苷衍生物公开(公告)号：US20140369959A1
公开(公告)日：2014-12-18
申请号：US14366189
申请日：2012-12-17
IPC分类号： C07H19/10 , A61K45/06 , A61K31/7068 , A61K31/7072
CPC分类号： C07H19/10 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/06 , C07H19/16
摘要： The present invention relates to the use of nucleoside derivatives of formula (I) wherein the symbols are as the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的核苷衍生物，其中符号如说明书及其药学上可接受的盐和含有这些化合物的药物组合物的用途。
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公开(公告)号：US09693997B2
公开(公告)日：2017-07-04
申请号：US14768915
申请日：2014-03-03
发明人： Joseph Anthony Bilotta , Zhi Chen , Feng Chi , Elbert Chin , Qingjie Ding , Shawn David Erickson , Stephen Deems Gabriel , Nan Jiang , Buelent Kocer , Eric Mertz , Jean-Marc Plancher , Robert J. Weikert , Jing Zhang , Qiang Zhang
IPC分类号： C07D249/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D491/107 , C07D495/04 , A61K31/4196 , A61K31/454 , A61K31/428 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61K45/06 , C07D411/12 , C07D413/12
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61K45/06 , C07D249/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D491/107 , C07D495/04
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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