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公开(公告)号：US09896433B2
公开(公告)日：2018-02-20
申请号：US14766646
申请日：2014-03-03
发明人： Zhi Chen , Elbert Chin , Shawn David Erickson , Stephen Deems Gabriel , Eric Mertz , Robert James Weikert
IPC分类号： C07D251/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07D471/04 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/501 , A61K31/502 , A61K38/21 , A61K45/06
CPC分类号： C07D401/12 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/501 , A61K31/502 , A61K38/21 , A61K45/06 , C07D403/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： The present invention discloses compounds of Formula I wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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公开(公告)号：US09693997B2
公开(公告)日：2017-07-04
申请号：US14768915
申请日：2014-03-03
发明人： Joseph Anthony Bilotta , Zhi Chen , Feng Chi , Elbert Chin , Qingjie Ding , Shawn David Erickson , Stephen Deems Gabriel , Nan Jiang , Buelent Kocer , Eric Mertz , Jean-Marc Plancher , Robert J. Weikert , Jing Zhang , Qiang Zhang
IPC分类号： C07D249/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D491/107 , C07D495/04 , A61K31/4196 , A61K31/454 , A61K31/428 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61K45/06 , C07D411/12 , C07D413/12
CPC分类号： A61K31/4196 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61K45/06 , C07D249/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D491/107 , C07D495/04
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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公开(公告)号：US20150152058A1
公开(公告)日：2015-06-04
申请号：US14615609
申请日：2015-02-06
发明人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Prabha Saba Karnachi , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号： C07D213/75 , C07D401/04 , C07D491/107 , C07D405/04 , C07D401/12 , C07D413/12 , C07D213/81
CPC分类号： C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
摘要： This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译： 本发明涉及下式的新的3-氨基吡啶类，其中B1，B2和R1至R6如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。
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4.发明授权4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds 有权4-苯氧基 - 烟酰胺或4-苯氧基 - 嘧啶-5-甲酰胺化合物公开(公告)号：US08729091B2
公开(公告)日：2014-05-20
申请号：US13767907
申请日：2013-02-15
发明人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号： A61K31/505 , A61K31/4427
CPC分类号： C07D417/14 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D417/12
摘要： This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译： 本发明涉及下式的新型苯基酰胺或吡啶基酰胺衍生物，其中A1，A2，B1，B2和R1至R11如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号：US09580411B2
公开(公告)日：2017-02-28
申请号：US14671643
申请日：2015-03-27
发明人： Christine E. Brotherton-Pleiss , Huifen Chen , Shaoqing Chen , Zhi Chen , Shawn David Erickson , Anthony Estrada , Kyungjin Kim , Hongju Li , Allen John Lovey , Joseph P. Lyssikatos , Yimin Qian , Sung-Sau So , Peter Michael Wovkulich , Lin Yi
IPC分类号： C07D305/08 , C07D409/12 , C07D231/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D237/08 , C07D239/42 , C07D409/14 , C07D241/12 , C07D213/26 , C07D213/40 , C07C311/19 , C07C311/16 , C07C311/17 , C07C311/20 , C07D239/26 , C07D305/06 , C07D403/12
CPC分类号： C07D409/12 , C07C311/16 , C07C311/17 , C07C311/19 , C07C311/20 , C07C2601/02 , C07D213/26 , C07D213/40 , C07D231/18 , C07D237/08 , C07D239/26 , C07D239/42 , C07D241/12 , C07D305/06 , C07D305/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/14
摘要： The invention is concerned with the compounds of formula (I): and salts thereof, wherein X, Y, Z, R1, R2, R3, R3′, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
摘要翻译： 本发明涉及式（I）化合物及其盐，其中X，Y，Z，R 1，R 2，R 3，R 3，R 4，R 5和R 6在详细说明书和权利要求书中定义。 此外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗TRPA1介导的疾病和病症，例如疼痛。
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公开(公告)号：US09359337B2
公开(公告)日：2016-06-07
申请号：US14712655
申请日：2015-05-14
IPC分类号： C07D211/26 , C07D413/04 , C07D265/30 , C07D207/09
CPC分类号： C07D413/04 , C07D207/09 , C07D211/26 , C07D265/30
摘要： The invention is concerned with a compound of formula (I) and pharmaceutically acceptable salts thereof wherein R1 to R3, X and Y are as defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R1至R3，X和Y如说明书和权利要求中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：US20150353511A1
公开(公告)日：2015-12-10
申请号：US14827762
申请日：2015-08-17
发明人： Joseph Anthony Bilotta , Zhi Chen , Qingjie Ding , Shawn David Erickson , Eric Mertz , Robert James Weikert
IPC分类号： C07D249/14 , A61K45/06 , A61K31/4439 , A61K31/4196 , C07D401/12
CPC分类号： A61K31/4439 , A61K31/4196 , A61K45/06 , C07D249/14 , C07D401/12
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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公开(公告)号：US09511059B2
公开(公告)日：2016-12-06
申请号：US14827762
申请日：2015-08-17
发明人： Joseph Anthony Bilotta , Zhi Chen , Qingjie Ding , Shawn David Erickson , Eric Mertz , Robert James Weikert
IPC分类号： C07D249/14 , C07D401/12 , A61K31/4439 , A61K31/4196 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/4196 , A61K45/06 , C07D249/14 , C07D401/12
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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公开(公告)号：US09353096B2
公开(公告)日：2016-05-31
申请号：US14683452
申请日：2015-04-10
发明人： Christine E. Brotherton-Pleiss , Zhi Chen , Shawn David Erickson , Kyungjin Kim , Hongju Li , Yimin Qian , Sung-Sau So , Peter Michael Wovkulich , Lin Yi
IPC分类号： C07D241/04 , C07D265/30 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/12
CPC分类号： C07D413/12 , C07D241/04 , C07D265/30 , C07D279/12 , C07D413/04 , C07D413/06
摘要： The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein Y, R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中Y，R 1，R 2和R 3在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 式（I）化合物是TRPA1通道的拮抗剂，可用于治疗与该通道相关的炎性疾病和病症。
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公开(公告)号：US09290465B2
公开(公告)日：2016-03-22
申请号：US14443849
申请日：2013-11-29
IPC分类号： C07D261/14 , C07D413/04 , C07D413/12
CPC分类号： C07D261/14 , C07D413/04 , C07D413/12
摘要： The invention is concerned with a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中R 1至R 3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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