公开(公告)号：US12259308B2

公开(公告)日：2025-03-25

申请号：US17793208

申请日：2021-01-15

Applicant: HORIBA ABX SAS ,  UNIVERSITE DE MONTPELLIER ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： Pierre Taraconat ,  Damien Isebe ,  Simon Mendez ,  Franck Nicoud

IPC: G01N15/12 ,  G01N15/01 ,  G01N33/487

Abstract: A medical analysis device with cellular impedance signal processing features a memory arranged to receive pulse data sets, with each pulse data set including impedance value data that are associated each time with a time marker. The pulse data sets together represent a curve of cellular impedance values that are measured as a cell passes through a polarised opening. The device further includes a classifier in communication with the memory. The classifier may feature a convolutional neural network that receives the pulse data sets as input. The classifier is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

公开(公告)号：US11385158B2

公开(公告)日：2022-07-12

申请号：US16760777

申请日：2018-10-30

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  HORIBA ABX SAS

Inventor： Pierre Blandin ,  Anais Ali-Cherif ,  Aurelien Daynes ,  Estelle Gremion ,  Damien Isebe

IPC: G01N15/02 ,  G06T7/62 ,  G06T7/11 ,  G01N15/14 ,  G03H1/00 ,  G03H1/08 ,  G01N15/00

Abstract: The invention is a method for estimating a representative volume of particles of interest (10 i) immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P 10), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (11), the light source emitting an incident light wave (12) propagating towards the sample (10) along a propagation axis (Z); b) acquiring, by means of an image sensor (16), an image (I 0) of the sample (10), formed in a detection plane (P 0), the sample being arranged between the light source (11) and the image sensor (16), each image being representative of a light wave (14) referred to as an exposure light wave, to which the image sensor (16) is exposed under the effect of illumination; c) using the image of the sample (I 0), acquired during step b), and a holographic propagation operator, to calculate a complex expression (A (x, y, z)) of the exposure light wave (14) in different positions relative to the detection plane; the method comprising a step of estimating the representative volume (AA) of the particles of interest (10 i) depending on the complex expressions calculated during step c).

公开(公告)号：US12196662B2

公开(公告)日：2025-01-14

申请号：US17606101

申请日：2020-04-24

Applicant: HORIBA ABX SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE MONTPELLIER

Inventor： Pierre Taraconat ,  Damien Isebe ,  Simon Mendez ,  Franck Nicoud

IPC: G01N15/12 ,  G01N15/01

Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

公开(公告)号：US10471421B2

公开(公告)日：2019-11-12

申请号：US14905779

申请日：2014-07-17

Applicant: HORIBA ABX SAS

Inventor： Didier Cremien ,  Damien Isebe

IPC: B01L3/02 ,  A61B5/15 ,  A61B5/157 ,  G01N35/10

Abstract: The present application relates to: (i) a sampler device for taking a sample of biological fluid, which comprises a capillary component, and a base rigidly connected to said capillary component and provided with a first connector capable of being reversibly attached in a leaktight manner to a second connector of a dispensing device; (ii) a dispensing device which also comprises means for transferring diluting fluid which open into said second connector. The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.