公开(公告)号：US10723809B2

公开(公告)日：2020-07-28

申请号：US15560141

申请日：2016-03-18

Applicant: HOWARD UNIVERSITY ,  James W. Mitchell ,  Dazhi Yang

Inventor： James W. Mitchell ,  Dazhi Yang

IPC: C08B15/02 ,  C08B15/06 ,  C08B15/00 ,  C08H1/00 ,  C12N5/00

Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.

公开(公告)号：US12186336B2

公开(公告)日：2025-01-07

申请号：US17077950

申请日：2020-10-22

Applicant: HOWARD UNIVERSITY

Inventor： James W. Mitchell ,  Dazhi Yang

IPC: A61K31/785 ,  A61K9/14 ,  A61K31/738 ,  A61P7/08 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C08B15/06 ,  C08F251/02 ,  C08G73/02 ,  C08G81/00 ,  C08G83/00 ,  C08J9/16 ,  C08L1/08 ,  C08L3/20 ,  C08L5/02 ,  C08L5/08 ,  C08G101/00

Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.

公开(公告)号：US10849927B2

公开(公告)日：2020-12-01

申请号：US15560131

申请日：2016-03-18

Applicant: HOWARD UNIVERSITY

Inventor： James W. Mitchell ,  Dazhi Yang

IPC: A61K31/785 ,  A61K31/738 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C08B15/06 ,  C08G81/00 ,  C08G83/00 ,  C08J9/16 ,  A61K9/14 ,  C08F251/02 ,  C08G73/02 ,  C08L1/08 ,  C08L3/20 ,  C08L5/02 ,  C08L5/08 ,  C08G101/00 ,  A61P7/08

Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.

公开(公告)号：US20180099007A1

公开(公告)日：2018-04-12

申请号：US15560131

申请日：2016-03-18

Applicant: Howard University

Inventor： James W. Mitchell ,  Dazhi Yang

IPC: A61K31/738 ,  A61K31/785 ,  C08L1/08 ,  C08L3/20 ,  C08L5/02 ,  C08L5/08 ,  C08G73/02 ,  C08F251/02 ,  B01J20/26 ,  B01J20/28

CPC classification number: A61K31/785 ,  A61K9/14 ,  A61K31/738 ,  A61P7/08 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28078 ,  B01J20/28085 ,  B01J20/3085 ,  C08B15/06 ,  C08F251/02 ,  C08G73/0206 ,  C08G81/00 ,  C08G83/002 ,  C08G2101/00 ,  C08G2210/00 ,  C08J9/16 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2387/00 ,  C08L1/08 ,  C08L3/20 ,  C08L5/02 ,  C08L5/08

Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.

公开(公告)号：US20180094080A1

公开(公告)日：2018-04-05

申请号：US15560141

申请日：2016-03-18

Applicant: Howard University

Inventor： James W. Mitchell ,  Dazhi Yang

IPC: C08B15/00 ,  C08B15/02 ,  C08B15/06 ,  C08H1/00 ,  C12N5/00

Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.