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公开(公告)号：US11267950B2
公开(公告)日：2022-03-08
申请号：US16520762
申请日：2019-07-24
Applicant: HOWARD UNIVERSITY
Inventor： Tongxin Wang , James W. Mitchell
Abstract: A method is provided for synthesizing PLA/apatite composites with improved mechanical strength. In one aspect, a calcium-phosphate/phosphonate hybrid shell is developed to incorporate more reactive hydroxyl groups onto hydroxyapatite (HA) particles. PLA is covalently bonded to HA calcium phosphate hybrid shell, creating a strong interphase between HA and PLA, thus significantly improve the mechanical strength in comparison to that of non-modified HA.
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2.发明授权公开(公告)号：US10723809B2
公开(公告)日：2020-07-28
申请号：US15560141
申请日：2016-03-18
Applicant: HOWARD UNIVERSITY , James W. Mitchell , Dazhi Yang
Inventor： James W. Mitchell , Dazhi Yang
Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.
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公开(公告)号：US20140134116A1
公开(公告)日：2014-05-15
申请号：US14075230
申请日：2013-11-08
Applicant: Colgate-Palmolive Company , Howard University
Inventor： Tongxin Wang , Yanda Lei , James W. Mitchell , Lynette Zaidel , Jianhong Qiu , Mahmoud Hassan
CPC classification number: A61K8/90 , A61K8/21 , A61Q11/00 , C08F293/005
Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same are also described.
Abstract translation: 这里描述的是具有疏水性嵌段和亲水性嵌段的嵌段共聚物，该嵌段共聚物有效结合硬组织的表面; 还描述了包含它们的组合物，以及制备和使用它们的方法。
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Patent Agency Ranking
公开(公告)号：US12186336B2
公开(公告)日：2025-01-07
申请号：US17077950
申请日：2020-10-22
Applicant: HOWARD UNIVERSITY
Inventor： James W. Mitchell , Dazhi Yang
IPC: A61K31/785 , A61K9/14 , A61K31/738 , A61P7/08 , B01J20/26 , B01J20/28 , B01J20/30 , C08B15/06 , C08F251/02 , C08G73/02 , C08G81/00 , C08G83/00 , C08J9/16 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08 , C08G101/00
Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.
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公开(公告)号：US10918588B2
公开(公告)日：2021-02-16
申请号：US14441782
申请日：2013-11-08
Applicant: COLGATE-PALMOLIVE COMPANY , HOWARD UNIVERSITY
Inventor： Tongxin Wang , Yanda Lei , James W. Mitchell , Lynette Zaidel , Jian-hong Qiu , Mahmoud Hassan
Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.
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公开(公告)号：US10849927B2
公开(公告)日：2020-12-01
申请号：US15560131
申请日：2016-03-18
Applicant: HOWARD UNIVERSITY
Inventor： James W. Mitchell , Dazhi Yang
IPC: A61K31/785 , A61K31/738 , B01J20/26 , B01J20/28 , B01J20/30 , C08B15/06 , C08G81/00 , C08G83/00 , C08J9/16 , A61K9/14 , C08F251/02 , C08G73/02 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08 , C08G101/00 , A61P7/08
Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.
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公开(公告)号：US20180099007A1
公开(公告)日：2018-04-12
申请号：US15560131
申请日：2016-03-18
Applicant: Howard University
Inventor： James W. Mitchell , Dazhi Yang
IPC: A61K31/738 , A61K31/785 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08 , C08G73/02 , C08F251/02 , B01J20/26 , B01J20/28
CPC classification number: A61K31/785 , A61K9/14 , A61K31/738 , A61P7/08 , B01J20/264 , B01J20/267 , B01J20/28004 , B01J20/28078 , B01J20/28085 , B01J20/3085 , C08B15/06 , C08F251/02 , C08G73/0206 , C08G81/00 , C08G83/002 , C08G2101/00 , C08G2210/00 , C08J9/16 , C08J2205/022 , C08J2207/10 , C08J2387/00 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08
Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.
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8.发明申请公开(公告)号：US20180094080A1
公开(公告)日：2018-04-05
申请号：US15560141
申请日：2016-03-18
Applicant: Howard University
Inventor： James W. Mitchell , Dazhi Yang
Abstract: Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.
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