-
公开(公告)号：US5424318A
公开(公告)日：1995-06-13
申请号：US177440
申请日：1994-01-05
申请人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61K31/505 , A61P21/00 , A61P25/02 , A61P25/18 , A61P25/28 , A61P43/00 , C07D211/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/70 , C07D211/94 , C07D213/00 , C07D239/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D487/04 , C12N9/99 , A01N43/40 , C07D211/08 , C07D241/40
CPC分类号： C07D401/06 , C07D211/22 , C07D211/26 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A novel piperidine derivative is defined by the formula (I), including a salt thereof, ##STR1## wherein R.sup.1 denotes anthraquinone, X denotes a group of the formula --(CH.sub.2).sub.n --, a group of the formula --O(CH.sub.2).sub.n --, a group of the formula --S(CH.sub.2).sub.n --, a group of the formula --NH(CH.sub.2).sub.n --, a group of the formula --SO.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR2## a group of the formula ##STR3## a group of the formula ##STR4## a group of the formula --CH.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR5## (in all the above formulas, n is an integer of 1 through 7 and R.sup.3 represents a lower alkyl group or a benzyl group), a group of the formula ##STR6## a group of the formula ##STR7## a group of the formula --O--CH.sub.2 CH.sub.2 CH.dbd. or a group of the formula ##STR8## the ring A denotes a group of the formula ##STR9## a group of the formula ##STR10## a group of the formula ##STR11## or a group of the formula ##STR12##
摘要翻译： 新颖的哌啶衍生物由式（I）定义，包括其盐，其中R 1表示蒽醌，X表示式 - （CH 2）n - 的基团，式-O的基团 （CH 2）n - ，式-S（CH 2）n - 的基团，式-NH（CH 2）n - 的基团，式-SO 2 NH（CH 2）n - 的基团，式
一组公式 一组公式 一组式-CH2NH（CH2）n-，式为一组式（IMAGE）（在所有上述公式中，n为 1〜7的整数，R3表示低级烷基或苄基），下式的基团：下式的基团：式-O-CH 2 CH 2 CH =的基团或式 环A表示一组公式 一组公式 一组公式 或一组公式 -
公开(公告)号：US4942169A
公开(公告)日：1990-07-17
申请号：US321624
申请日：1989-03-10
申请人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61K31/505 , A61P21/00 , A61P25/02 , A61P25/18 , A61P25/28 , A61P43/00 , C07D211/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/70 , C07D211/94 , C07D213/00 , C07D239/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D487/04 , C12N9/99
CPC分类号： C07D401/06 , C07D211/22 , C07D211/26 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A novel piperidine derivative is defined by the formula (I), including a salt thereof, ##STR1## wherein R.sup.1 denotes a univalent group derived from one selected among substituted or unsubstituted benzene, pyridine, pyrazine, indole, anthraquinone, quinoline, substituted or unsubstituted phthalimide, homophthalimide, pyridinecarboxylic acid imide, pyridine N-oxide, pyrazinedicarboxylic acid imide, naphthalenedicarboxylic acid imide, substituted or unsubstituted quinazolinedione, 1,8-naphthalimide, bicyclo [2.2.2.] oct-5-ene-2,3-dicarboxylic acid imide and pyromerylimide,X denotes a group of the formula --(CH.sub.2).sub.n --, a group of the formula --O(CH.sub.2).sub.n --, a group of the formula --S(CH.sub.2).sub.n --, a group of the formula --NH(CH.sub.2).sub.n --, a group of the formula --SO.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR2## a group of the formula ##STR3## a group of the formula ##STR4## a group of the formula --CH.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR5## (in all the above formulas, n is an integer of 1 through 7 and R.sup.3 represents a lower alkyl group or a benzyl group), a group of the formula ##STR6## a group of the formula ##STR7## a group of the formula --O--CH.sub.2 CH.sub.2 CH.dbd. or a group of the formula ##STR8## the ring A denotes a group of the formula ##STR9## a group of the formula ##STR10## a group of the formula ##STR11## or a group of the formula ##STR12## and R.sup.2 denotes a hydrogen atom, a lower alkyl group, a substituted or unsubstituted benzyl group, a substituted or unsubstituted benzoly group, a pyridyl group, a 2-hydroxyethyl group, a pyridylmethyl group or a group of the formula ##STR13## (wherein Z represents a halogen atom).
-
公开(公告)号：US4849431A
公开(公告)日：1989-07-18
申请号：US946459
申请日：1986-12-24
申请人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61K31/505 , A61P21/00 , A61P25/02 , A61P25/18 , A61P25/28 , A61P43/00 , C07D211/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/70 , C07D211/94 , C07D213/00 , C07D239/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D487/04 , C12N9/99
CPC分类号： C07D401/06 , C07D211/22 , C07D211/26 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A novel piperidine derivative or a pharmacologically acceptable salt thereof is used in the treatment and prevention of dementias and sequelae of cerebrovascular diseases. These compounds also exhibit strong, highly selective anticholinesterase activity and may be orally or parenterally administered.
摘要翻译： 新颖的哌啶衍生物或其药理学上可接受的盐用于治疗和预防脑血管疾病的痴呆和后遗症。 这些化合物还表现出强烈的，高选择性的抗胆碱酯酶活性，并且可以口服或肠胃外给药。
-
公开(公告)号：US5654306A
公开(公告)日：1997-08-05
申请号：US435367
申请日：1995-05-05
申请人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61K31/505 , A61P21/00 , A61P25/02 , A61P25/18 , A61P25/28 , A61P43/00 , C07D211/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/70 , C07D211/94 , C07D213/00 , C07D239/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D487/04 , C12N9/99 , C07D401/00
CPC分类号： C07D401/06 , C07D211/22 , C07D211/26 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A piperdine derivative having the formula (I) or a pharmacologically acceptable salt thereof:R.sup.1 --X--A--R.sup.2 (I)wherein R.sup.1 is selected from the group consisting of substituted or unsubstituted pyrazine, naphthalenedicarboxylic acid imide, bicyclo oct-5-ene-2,3-dicarboxylic acid imide and pyromellitimide;X is --(CH.sub.2).sub.n --, --O(CH.sub.2).sub.n --, --S(CH.sub.2).sub.n --, --NH(CH.sub.2).sub.n --, --SO.sub.1 NH(CH.sub.2).sub.n --, ##STR1## --CH.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR2## wherein n is an integer of 1 through 7 and R.sup.3 is hydrogen, lower alkyl or a benzyl, ##STR3## --O--CH.sub.2 CH.sub.2 CH.dbd. or ##STR4## R.sup.2 is hydrogen, lower alkyl, benzyl, benzyl substituted with hydroxy, methoxy or chlorine, benzoyl, benzyl with a fluorine substituent, pyridyl, 2-hydroxyethyl, pyridylmethyl or ##STR5## wherein Z represents a halogen atom.
摘要翻译： 具有式（I）的哌啶衍生物或其药理学上可接受的盐：R1-XA-R2（I）其中R1选自取代或未取代的吡嗪，萘二甲酰亚胺，二环辛-5-烯-2 ，3-二羧酸酰亚胺和均苯四酰亚胺; X是 - （CH 2）n - ， - O（CH 2）n - ， - S（CH 2）n - ， - NH（CH 2）n - ， - SO 1 NH（CH 2）n - ， - - ，式为“IMAGE”的基团，其中n为1至7的整数，R 3为氢，低级烷基或苄基，苄基，被羟基取代的苄基 甲氧基或氯，苯甲酰基，具有氟取代基的苄基，吡啶基，2-羟乙基，吡啶基甲基或其中Z表示卤素原子。
-
公开(公告)号：US5118684A
公开(公告)日：1992-06-02
申请号：US679769
申请日：1991-04-03
申请人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61K31/505 , A61P21/00 , A61P25/02 , A61P25/18 , A61P25/28 , A61P43/00 , C07D211/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/70 , C07D211/94 , C07D213/00 , C07D239/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D487/04 , C12N9/99
CPC分类号： C07D401/06 , C07D211/22 , C07D211/26 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A novel piperidine derivative is defined by the formula (I), including a slt thereof, ##STR1## wherein R.sup.1 denotes a univalent group derived from one selected among substituted or unsubstituted benzene, pyridine, pyrazine, indole, anthraquinone, quinoline, substituted or unsubstituted phthalimide, homophthalimide, pyridinecarboxylic acid imide, pyridine N-oxide, pyrazinedicarboxylic acid imide, naphthalenedicarboxylic acid imide, substituted or unsubstituted quinazolinedione, 1,8-naphthalimide, bicyclo [2.2.2] oct-5-ene-2,3-dicarboxylic acid imide and pyromerylimide,X denotes a group of the formula --(CH.sub.2).sub.n --, a group of the formula --O(CH.sub.2).sub.n --, a group of the formula --S(CH.sub.2).sub.n --, a group of the formula --NH(CH.sub.2).sub.n --, a group of the formula --SO.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR2## a group of the formula ##STR3## a group of the formula ##STR4## a group of the formula --CH.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR5## (in all the above formulas, n is an integer of 1 through 7 and R.sup.3 represents a lower alkyl group or a benzyl group), a group of the formula ##STR6## a group of the formula ##STR7## a group of the formula --O--CH.sub.2 CH.sub.2 CH= or a group of the formula ##STR8## the ring A denotes a group of the formula ##STR9## a group of the formula ##STR10## a group of the formula ##STR11## or a group of the formula ##STR12## and R.sup.2 denotes a hydrogen atom, a lower alkyl group, a substituted or unsubstituted benzyl group, a substituted or unsubstituted benzoyl group, a pyridyl group, a 2-hydroxyethyl group, a pyridylmetyl group or a group of the formula ##STR13## (wherein Z represents a halogen atom).
-
公开(公告)号：US5039681A
公开(公告)日：1991-08-13
申请号：US479948
申请日：1990-02-14
申请人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61K31/505 , A61P21/00 , A61P25/02 , A61P25/18 , A61P25/28 , A61P43/00 , C07D211/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/70 , C07D211/94 , C07D213/00 , C07D239/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D487/04 , C12N9/99
CPC分类号： C07D401/06 , C07D211/22 , C07D211/26 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A novel piperidine derivative is defined by the formula (I), including a salt thereof, ##STR1## wherein R.sup.1 denotes a univalent group derived from one selected among substituted or unsubstituted benzene, pyridine, pyrazine, indole, anthraquinone, quinoline, substituted or unsubstituted phthalimide, homophthalimide, pyridinecarboxylic acid imide, pyridine N-oxide, pyrazinedicarboxylic acid imide, naphthalenedicarboxylic acid imide, substituted or unsubstituted quinazolinedione, 1,8-naphthalimide, bicyclo [2.2.2] oct-5-ene-2,3-dicarboxylic acid imide and pyromerylimide,X denotes a group of the formula --(CH.sub.2).sub.n --, a group of the formula --O(CH.sub.2).sub.n --, a group of the formula --S(CH.sub.2).sub.n --, a group of the formula --NH(CH.sub.2).sub.n --, a group of the formula --SO.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR2## a group of the formula ##STR3## a group of the formula ##STR4## a group of the formula --CH.sub.2 NH(CH.sub.2).sub.n --, a group of the formula ##STR5## (in all the above formulas, n is an integer of 1 through 7 and R.sup.3 represents a lower alkyl group or a benzyl group), a group of the formula a group of the formula ##STR6## a group of the formula --O--CH.sub.2 CH.sub.2 CH.dbd. or a group of the formula ##STR7## the ring A denotes a group of the formula ##STR8## a group of the formula ##STR9## a group of the formula ##STR10## or a group of the formula andR.sup.2 denotes a hydrogen atom, a lower alkyl group, a substituted or unsubstituted benzyl group, a substituted or unsubstituted benzoyl group, a pyridyl group, a 2-hydroxyethyl group, a pyridylmethyl group or a group of the formula ##STR11## (wherein Z represents a halogen atom).
-
公开(公告)号：US5306720A
公开(公告)日：1994-04-26
申请号：US811698
申请日：1991-12-20
申请人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Yutaka Tsuchiya , Hiroyuki Sugumi , Kunizou Higurashi , Norio Karibe , Yoshiharu Yamanishi , Hiroo Ogura , Shin Araki , Atsuhiko Kubota , Michiko Ohtake , Kiyomi Tamatsu
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/495 , A61K31/505 , A61P21/00 , A61P25/02 , A61P25/18 , A61P25/28 , A61P43/00 , C07D211/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/70 , C07D211/94 , C07D213/00 , C07D239/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D471/04 , C07D487/04 , C12N9/99
CPC分类号： C07D401/06 , C07D211/22 , C07D211/26 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： A novel piperidine derivative is defined by the formula (I), including a salt thereof, ##STR1## wherein R.sup.1 denotes a univalent group derived from substituted or unsubstituted quinazolinedione,X denotes a group of the formula ##STR2## n is an integer of 1 through 7, the ring A denotes a group of the formula ##STR3## a group of the formula ##STR4## or a group of the formula ##STR5## and R.sup.2 denotes a hydrogen atom, a lower alkyl group, a substituted benzoyl group, a pyridyl group, a 2-hydroxyethyl group, a pyridylmethyl group, or a group of the formula ##STR6## wherein Z represents a halogen atom). The novel compounds of this invention are used for treating dementias and sequelae of cerebrovascular diseases.
摘要翻译： 新颖的哌啶衍生物由式（I）定义，包括其盐，其中R 1表示衍生自取代或未取代的喹唑啉二酮的一价基团，X表示下式的基团：n是 1〜7的整数，环A表示式“IMAGE”的基团，即式（IMAGE）的基团或式（IMAGE）的基团，R 2表示氢原子，低级烷基，取代的苯甲酰基 基团，吡啶基，2-羟基乙基，吡啶基甲基或下式的基团，其中Z表示卤素原子）。 本发明的新化合物用于治疗脑血管疾病的痴呆和后遗症。
-
公开(公告)号：US4921863A
公开(公告)日：1990-05-01
申请号：US177662
申请日：1988-02-17
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizou Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizou Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu
IPC分类号： C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07D215/12 , C07D295/02 , C07D295/03 , C07D295/108 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D295/03 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07D215/12 , C07D295/108 , C07D401/06 , C07D405/06 , C07D409/06
摘要： Cyclic amine derivatives of the formula: ##STR1## or the pharmacologically acceptable salts thereof, wherein the symbols are as defined in the specification, as effective in relieving, curing or preventing mental symptoms due to cerebral vascular disorders.
摘要翻译： PCT No.PCT / JP86 / 00502 Sec。 371日期1988年2月17日 102（e）日期1988年2月17日PCT提交1986年9月30日PCT公布。 公开号WO88 / 02365 日期：1988年4月7日。下式的环胺衍生物或其药理学上可接受的盐，其中符号如本说明书中所定义，有效缓解，治愈或预防由于脑血管病症引起的精神症状。
-
公开(公告)号：US5196439A
公开(公告)日：1993-03-23
申请号：US825423
申请日：1992-01-24
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
IPC分类号： C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04 , C07D401/12
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --O--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat mental symptoms associated with a cerebrovascular disease.
摘要翻译： 环胺由下式定义：其中A为萘基，苯基，喹啉基或烷基，X为含羰基的基团，n为2或3，B为烷基，卤素，苯基或-YZ ，Y为-O-，-CO-或-NH-，Z为苯基，萘基，吡啶基，烷基或环烷基。 治疗与脑血管病相关的精神症状是有用的。
-
公开(公告)号：US5523307A
公开(公告)日：1996-06-04
申请号：US258798
申请日：1994-06-07
申请人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
发明人： Hachiro Sugimoto , Takaharu Nakamura , Norio Karibe , Isao Saito , Kunizo Higurashi , Masahiro Yonaga , Takeru Kaneko , Takahiro Nakazawa , Masataka Ueno , Kiyomi Yamatsu , Kohshi Ueno , Masuhiro Ikeda
IPC分类号： C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04 , C07D401/12 , A61K31/44 , A61K31/445 , A61K31/47
CPC分类号： C07D401/12 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/58 , C07D223/04
摘要： A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --0--, --CO-- or --NH--, Z being phenyl, naphthyl, pyridyl, alkyl or cycloalkyl. It is useful to treat a mental symptoms associated with a cerebrovascular disease.
摘要翻译： 环胺由下式定义：其中A为萘基，苯基，喹啉基或烷基，X为含羰基的基团，n为2或3，B为烷基，卤素，苯基或-YZ Y是-O - ， - CO-或-NH-，Z是苯基，萘基，吡啶基，烷基或环烷基。 治疗与脑血管疾病相关的精神症状是有用的。
-
-
-
-
-
-
-
-
-
搜索结果
65 条记录 (耗时 0.038 秒)
