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13 条记录 (耗时 0.032 秒)

    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
    5.
    发明授权
    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 失效
    包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法

    公开(公告)号：US06403675B1

    公开(公告)日：2002-06-11

    申请号：US09070204

    申请日：1998-04-30

    申请人： Wenbin Dang ,  Hai-quan Mao ,  Irina Kadiyala ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Wenbin Dang ,  Hai-quan Mao ,  Irina Kadiyala ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： A61K3180

    CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

    摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L是二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。 还描述了除了聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法。

    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
    6.
    发明授权
    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 有权
    包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法

    公开(公告)号：US06800672B2

    公开(公告)日：2004-10-05

    申请号：US10011570

    申请日：2001-12-04

    申请人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

    发明人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

    IPC分类号： A61K3180

    CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

    摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L为二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。除聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法也是 描述。

    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
    7.
    发明授权
    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same 失效
    用于治疗卵巢癌，聚（磷酸酯）组合物和用于其的生物可降解制品的方法

    公开(公告)号：US06479067B2

    公开(公告)日：2002-11-12

    申请号：US09819376

    申请日：2001-03-28

    申请人： Wenbin Dang

    发明人： Wenbin Dang

    IPC分类号： A61F202

    CPC分类号： A61K9/1647 ,  A61K9/7007 ,  Y10S977/911 ,  Y10S977/912

    摘要： Biodegradeable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradeable polymer. Solid articles and methods for treating ovarian cancer are also described.

    摘要翻译： 描述适用于腹膜内给药以治疗具有卵巢癌的哺乳动物受试者的生物可降解聚合物组合物，其中所述聚合物组合物将抗肿瘤剂延长释放到受试者腹膜中。 与通过施用包含相同剂量的抗肿瘤剂的组合物而没有生物可降解聚合物的组合物获得的中位数存活率相比，主题组合物可以将来自癌症的中位生存期增加至少约10％。 还描述了用于治疗卵巢癌的固体制品和方法。

    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
    8.
    发明授权
    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same 失效
    用于治疗卵巢癌，聚（磷酸酯）组合物和用于其的生物可降解制品的方法

    公开(公告)号：US06350464B1

    公开(公告)日：2002-02-26

    申请号：US09227852

    申请日：1999-01-11

    申请人： Wenbin Dang

    发明人： Wenbin Dang

    IPC分类号： A61F202

    CPC分类号： A61K9/1647 ,  A61K9/7007 ,  Y10S977/911 ,  Y10S977/912

    摘要： Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.

    摘要翻译： 描述了适用于腹膜内给药以治疗具有卵巢癌的哺乳动物受试者的可生物降解的聚合物组合物，其中所述聚合物组合物将抗肿瘤剂延长释放到受试者腹膜中。 与通过施用包含相同剂量的抗肿瘤剂的组合物而不使用生物可降解聚合物的组合物获得的中值存活率相比，主题组合物可将癌症的中值存活率提高至少约10％。 还描述了用于治疗卵巢癌的固体制品和方法。

    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
    9.
    发明授权
    Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same 失效

    公开(公告)号：US06641833B2

    公开(公告)日：2003-11-04

    申请号：US10264793

    申请日：2002-10-04

    申请人： Wenbin Dang

    发明人： Wenbin Dang

    IPC分类号： A61F202

    CPC分类号： A61K9/1647 ,  A61K9/7007 ,  Y10S977/911 ,  Y10S977/912

    摘要： Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.

    Multipart drug delivery system
    10.
    发明授权
    Multipart drug delivery system 失效
    多药物输送系统

    公开(公告)号：US06322815B1

    公开(公告)日：2001-11-27

    申请号：US08279302

    申请日：1994-07-22

    申请人： W. Mark Saltzman ,  O. Michael Colvin ,  Wenbin Dang ,  Susan Ludeman

    发明人： W. Mark Saltzman ,  O. Michael Colvin ,  Wenbin Dang ,  Susan Ludeman

    IPC分类号： A61K914

    CPC分类号： A61K47/34 ,  A61K47/61

    摘要： Polymeric drug conjugates in controlled release matrices are provided which allow sustained concentrations of therapeutic agents within a treated area for a prolonged period. The polymeric drug conjugates hydrolytically degrade in the extracellular space in a controlled, pre-specified pattern, releasing active drug. The conjugates diffuse within the tissue reaching a greater distance from the matrix than free drug would, because of their reduced rate of clearance from the tissue via the capillary system.

    摘要翻译： 提供控制释放基质中的聚合物药物偶联物，其允许治疗区域内持续浓度的治疗剂长时间。 聚合物药物缀合物在受控的预先规定的模式中在细胞外空间中水解降解，释放活性药物。 由于它们通过毛细管系统从组织中的清除率降低，所以组合物在组织内扩散到与基质相比比自由药物更大的距离。