公开(公告)号：US06322815B1

公开(公告)日：2001-11-27

申请号：US08279302

申请日：1994-07-22

申请人： W. Mark Saltzman ,  O. Michael Colvin ,  Wenbin Dang ,  Susan Ludeman

发明人： W. Mark Saltzman ,  O. Michael Colvin ,  Wenbin Dang ,  Susan Ludeman

IPC分类号： A61K914

CPC分类号： A61K47/34 ,  A61K47/61

摘要： Polymeric drug conjugates in controlled release matrices are provided which allow sustained concentrations of therapeutic agents within a treated area for a prolonged period. The polymeric drug conjugates hydrolytically degrade in the extracellular space in a controlled, pre-specified pattern, releasing active drug. The conjugates diffuse within the tissue reaching a greater distance from the matrix than free drug would, because of their reduced rate of clearance from the tissue via the capillary system.

摘要翻译： 提供控制释放基质中的聚合物药物偶联物，其允许治疗区域内持续浓度的治疗剂长时间。 聚合物药物缀合物在受控的预先规定的模式中在细胞外空间中水解降解，释放活性药物。 由于它们通过毛细管系统从组织中的清除率降低，所以组合物在组织内扩散到与基质相比比自由药物更大的距离。

公开(公告)号：US06485737B1

公开(公告)日：2002-11-26

申请号：US09722848

申请日：2000-11-27

申请人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wenbin Dang ,  James P. English ,  David P. Nowotnik

发明人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wenbin Dang ,  James P. English ,  David P. Nowotnik

IPC分类号： A61F202

CPC分类号： C08G63/6926 ,  A61K9/0024 ,  A61K9/1647 ,  A61L17/105 ,  A61L24/046 ,  A61L31/06 ,  Y10S977/795 ,  Y10S977/915 ,  Y10T428/2982 ,  C08L67/00

摘要： A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 3-7, 500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

摘要翻译： 描述了包含可生物降解的对苯二甲酸酯共聚物的医疗装置，其包含式I所示的重复单体单元：其中R是二价有机部分; R'是脂族，芳族或杂环残基; x = 1; andn为3-7,500，其中生物可降解聚合物足够纯以生物相容性，并且在生物降解时能够形成生物相容性残基。含有共聚物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品 ，以及使用共聚物可控地释放生物活性物质的方法。

公开(公告)号：US06479067B2

公开(公告)日：2002-11-12

申请号：US09819376

申请日：2001-03-28

申请人： Wenbin Dang

发明人： Wenbin Dang

IPC分类号： A61F202

CPC分类号： A61K9/1647 ,  A61K9/7007 ,  Y10S977/911 ,  Y10S977/912

摘要： Biodegradeable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradeable polymer. Solid articles and methods for treating ovarian cancer are also described.

摘要翻译： 描述适用于腹膜内给药以治疗具有卵巢癌的哺乳动物受试者的生物可降解聚合物组合物，其中所述聚合物组合物将抗肿瘤剂延长释放到受试者腹膜中。 与通过施用包含相同剂量的抗肿瘤剂的组合物而没有生物可降解聚合物的组合物获得的中位数存活率相比，主题组合物可以将来自癌症的中位生存期增加至少约10％。 还描述了用于治疗卵巢癌的固体制品和方法。

公开(公告)号：US06350464B1

公开(公告)日：2002-02-26

申请号：US09227852

申请日：1999-01-11

申请人： Wenbin Dang

发明人： Wenbin Dang

IPC分类号： A61F202

CPC分类号： A61K9/1647 ,  A61K9/7007 ,  Y10S977/911 ,  Y10S977/912

摘要： Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.

摘要翻译： 描述了适用于腹膜内给药以治疗具有卵巢癌的哺乳动物受试者的可生物降解的聚合物组合物，其中所述聚合物组合物将抗肿瘤剂延长释放到受试者腹膜中。 与通过施用包含相同剂量的抗肿瘤剂的组合物而不使用生物可降解聚合物的组合物获得的中值存活率相比，主题组合物可将癌症的中值存活率提高至少约10％。 还描述了用于治疗卵巢癌的固体制品和方法。

公开(公告)号：US06641833B2

公开(公告)日：2003-11-04

申请号：US10264793

申请日：2002-10-04

申请人： Wenbin Dang

发明人： Wenbin Dang

IPC分类号： A61F202

CPC分类号： A61K9/1647 ,  A61K9/7007 ,  Y10S977/911 ,  Y10S977/912

摘要： Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.

公开(公告)号：US06322797B1

公开(公告)日：2001-11-27

申请号：US09053648

申请日：1998-04-02

申请人： Hai-Quan Mao ,  Kam W. Leong ,  Wenbin Dang ,  Hungnan Lo ,  Zhong Zhao ,  David P. Nowotnik ,  James P. English

发明人： Hai-Quan Mao ,  Kam W. Leong ,  Wenbin Dang ,  Hungnan Lo ,  Zhong Zhao ,  David P. Nowotnik ,  James P. English

IPC分类号： C08G7902

CPC分类号： C08G63/6926 ,  A61K9/1647 ,  A61L17/12 ,  A61L26/0019 ,  A61L27/18 ,  Y10T428/2938 ,  Y10T442/3545 ,  C08L85/02

摘要： Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; R′ is an aliphatic, aromatic or heterocyclic residue; x is ≧1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

摘要翻译： 描述了可生物降解的对苯二甲酸酯聚合物，其包含式I所示的重复单体单元：其中R是二价有机部分; R'是脂族，芳族或杂环残基; x是> = 1; andn为0-5,000，其中生物可降解聚合物在生物降解之前和之后是生物相容的。用于制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及可控制的方法 还使用聚合物释放生物活性物质。

公开(公告)号：US07101568B2

公开(公告)日：2006-09-05

申请号：US10357292

申请日：2003-02-03

申请人： Wenbin Dang ,  Robert Garver, Jr.

发明人： Wenbin Dang ,  Robert Garver, Jr.

IPC分类号： A61F2/02 ,  A61F9/50 ,  A61F47/30

CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61K31/337 ,  A61K47/34

摘要： A biodegradable polymer composition comprising: (a) a poly(phosphoester) biodegradable polymer and (b) at least one antineoplastic agent in an amount effective to inhibit the growth of a solid tumor, which is suitable for intratumoral administration to treat a mammal having a solid tumor.

公开(公告)号：US06800672B2

公开(公告)日：2004-10-05

申请号：US10011570

申请日：2001-12-04

申请人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

发明人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

IPC分类号： A61K3180

CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L为二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。除聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法也是 描述。

公开(公告)号：US06537585B1

公开(公告)日：2003-03-25

申请号：US09276866

申请日：1999-03-26

申请人： Wenbin Dang ,  Robert I. Garver, Jr.

发明人： Wenbin Dang ,  Robert I. Garver, Jr.

IPC分类号： A61K950

CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61K31/337 ,  A61K47/34

摘要： A biodegradable polymer composition comprising: (a) a poly(phosphoester) biodegradable polymer and (b) at least one antineoplastic agent in an amount effective to inhibit the growth of a solid tumor, which is suitable for intratumoral administration to treat a mammal having a solid tumor.

摘要翻译： 一种可生物降解的聚合物组合物，其包含：（a）聚（磷酸酯）可生物降解的聚合物和（b）至少一种抗肿瘤剂，其量为有效抑制实体瘤的生长，其适用于肿瘤内施用以治疗具有固体的哺乳动物 瘤。

公开(公告)号：US20050238616A1

公开(公告)日：2005-10-27

申请号：US10500795

申请日：2003-01-09

申请人： Wenbin Dang ,  Dana Hilt ,  William Vincek

发明人： Wenbin Dang ,  Dana Hilt ,  William Vincek

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K31/337 ,  A61K31/74

CPC分类号： A61K9/0024 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/204 ,  A61K31/337 ,  A61K41/0038

摘要： The present invension relates to compositions of a biocompatible polymer and a antineoplastic agent for treating central nervous system neoplasms, and methods of using and making the same. In certain embodiments, the polymer contains phosphorous linkages. In other embodiments, the antineoplastic agent is an antineoplastic taxane. In still other embodiments, the subject methods of treatment use electromagnetic radiation.

摘要翻译： 本发明涉及生物相容性聚合物和用于治疗中枢神经系统肿瘤的抗肿瘤剂的组合物，以及使用和制备其的方法。 在某些实施方案中，聚合物含有磷键。 在其它实施方案中，抗肿瘤剂是抗肿瘤紫杉烷。 在其它实施例中，本发明的治疗方法使用电磁辐射。