公开(公告)号：US06826424B1

公开(公告)日：2004-11-30

申请号：US09741731

申请日：2000-12-19

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC分类号： A61B505

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Methods and apparatus for contemporaneous measurements of electromagnetic radiation with multiple measuring devices, for producing a high diagnostic sensitivity image while achieving high diagnostic specificity with spectroscopy, for producing illumination for fluorescence/NIR reflectance imaging and white light reflectance imaging, all with the same sensors are disclosed. The method may involve selectively adjusting a gain of an imaging device in at least one wavelength band relative to a gain in at least one other band to produce an optimized image of an object, and may also involve producing a first reflectance signal in a first NIR wavelength band, and producing a second reflectance signal in a second NIR band such that an absorption coefficient ratio of oxyhemoglobin to deoxyhemoglobin in the second wavelength band differs from that in the first wavelength band, to permit the first and second reflectance signals to be used to produce a tissue oxygenation image.

摘要翻译： 用于同时测量具有多个测量装置的电磁辐射的方法和装置，用于产生高诊断灵敏度图像，同时通过光谱法实现高诊断特异性，用于产生用于荧光/ NIR反射成像的照明和具有相同传感器的白光反射成像 披露 该方法可以包括相对于至少一个其他频带中的增益选择性地调节成像装置在至少一个波长带中的增益，以产生对象的优化图像，并且还可以涉及在第一NIR中产生第一反射信号 并且在第二NIR带中产生第二反射信号，使得第二波长带中的氧合血红蛋白与脱氧血红蛋白的吸收系数比与第一波长带的吸收系数比不同，以允许将第一和第二反射信号用于 产生组织氧合图像。

公开(公告)号：US07190452B2

公开(公告)日：2007-03-13

申请号：US11058045

申请日：2005-02-14

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC分类号： G01J3/28

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

摘要翻译： 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US07253894B2

公开(公告)日：2007-08-07

申请号：US11053263

申请日：2005-02-07

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC分类号： G01J3/28

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

摘要翻译： 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US07115841B2

公开(公告)日：2006-10-03

申请号：US11057965

申请日：2005-02-14

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC分类号： H05B3/02

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

摘要翻译： 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。