公开(公告)号：US20240318158A1

公开(公告)日：2024-09-26

申请号：US18659215

申请日：2024-05-09

申请人： Halozyme, Inc,

发明人： Ge WEI ,  H. Michael SHEPARD ,  Qiping Zhao ,  Robert James CONNOR

IPC分类号： C12N9/26 ,  A61K9/00 ,  A61K38/00 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K9/0019 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34 ,  C12Y302/01035 ,  A61K38/00 ,  C07K2319/30 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US20220372151A1

公开(公告)日：2022-11-24

申请号：US17850903

申请日：2022-06-27

申请人： HALOZYME, INC.

发明人： Sanna ROSENGREN ,  H. Michael SHEPARD ,  Curtis B. THOMPSON

IPC分类号： C07K16/28 ,  A61K38/47 ,  A61K31/573 ,  A61K39/395 ,  A61P35/00 ,  C12N9/26 ,  C12N15/00 ,  A61K47/60

摘要： Provided are methods of treatment of cancers with combinations of and compositions containing a soluble hyaluronidase, such as a polymer-modified soluble hyaluronidase, and an immune checkpoint inhibitor for treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided.

公开(公告)号：US20230203470A1

公开(公告)日：2023-06-29

申请号：US18059135

申请日：2022-11-28

申请人： Halozyme, Inc.

发明人： Christopher D. THANOS ,  Lin WANG ,  H. Michael SHEPARD

IPC分类号： C12N9/78 ,  A61K38/48

CPC分类号： C12N9/78 ,  C12Y305/04004 ,  A61K38/48 ,  A61K38/00

摘要： Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.