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    Pharmaceutical tablets with diffractive microstructure and compression tools for producing such tablets
    3.
    发明授权
    Pharmaceutical tablets with diffractive microstructure and compression tools for producing such tablets 有权
    具有衍生微结构的药物片剂和用于生产这种片剂的压缩工具

    公开(公告)号：US09592646B2

    公开(公告)日：2017-03-14

    申请号：US12308484

    申请日：2007-06-12

    申请人： Alexander Stuck ,  Harald Walter ,  Marc Schnieper ,  Jürgen Söchtig ,  Christian Zschokke

    发明人： Alexander Stuck ,  Harald Walter ,  Marc Schnieper ,  Jürgen Söchtig ,  Christian Zschokke

    IPC分类号： A61K9/20 ,  B30B15/06 ,  A61J3/10 ,  A61J3/00

    CPC分类号： B30B15/065 ,  A61J3/007 ,  A61J3/10 ,  A61K9/2072 ,  A61K9/2095

    摘要： A tablet for pharmaceutical use has on at least one part of its surface a diffractive microstructure which generates diffraction effects which can be perceived in the visible spectral range and which serve as visual safety feature. The tablet includes a plurality of individual powder particles, where the diffractive microstructures are impressed into the surface of the individual powder particles. A compression tool to produce such tablets has on one pressing surface of the compression tool micro-structures, where the microstructures have dimensions which are smaller than the dimensions of the individual crystallites of the material of the pressing surface of the compression tool. The micro-structures of the compression tool can be produced for example by ion etching or by imprinting.

    摘要翻译： 用于药物用途的片剂在其表面的至少一部分上具有衍生微结构，其产生可在可见光谱范围内感觉并且用作视觉安全特征的衍射效应。 片剂包括多个单独的粉末颗粒，其中衍射微结构被印刷到各个粉末颗粒的表面中。 用于生产这种片剂的压缩工具具有在压缩工具微结构的一个按压表面上，其中微结构具有的尺寸小于压缩工具的压制表面的材料的各个微晶的尺寸。 压缩工具的微结构可以例如通过离子蚀刻或压印来制造。

    PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLPROPANONES
    4.
    发明申请
    PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLPROPANONES 有权
    制备取代的苯丙酮的方法

    公开(公告)号：US20150031919A1

    公开(公告)日：2015-01-29

    申请号：US14379013

    申请日：2012-02-28

    申请人： Daniel Stierli ,  Harald Walter

    发明人： Daniel Stierli ,  Harald Walter

    IPC分类号： C07C45/45

    CPC分类号： C07C45/455 ,  C07C45/516 ,  C07C49/457

    摘要： The invention relates to a process for the preparation of a compound of formula (I) wherein the substituents are defined as in claim 1, which process comprises adding a compound of formula (II), wherein R1, R2 and R3 have the meanings as described under formula (I), in the presence of an inert organic solvent, to a mixture comprising an organic nitrite of formula (III) R4—O—N═O, wherein R4 is C1-C8alkyl, a compound of formula (IV), and an inert organic solvent.

    摘要翻译： 本发明涉及一种制备式（I）化合物的方法，其中取代基如权利要求1所定义，该方法包括加入式（II）化合物，其中R 1，R 2和R 3具有如上所述的含义 在式（I）的存在下，在惰性有机溶剂的存在下，向包含式（III）的有机亚硝酸酯的R 4 -O-N = O（其中R 4为C 1 -C 8烷基），式（IV）的化合物， 和惰性有机溶剂。

    Manufacturing Solid Pharmaceutical Dosage Forms With Visible Micro- And Nanostructured Surfaces And Micro- And Nanostructured Pharmaceutical Dosage Form
    5.
    发明申请
    Manufacturing Solid Pharmaceutical Dosage Forms With Visible Micro- And Nanostructured Surfaces And Micro- And Nanostructured Pharmaceutical Dosage Form 审中-公开
    制造具有可见微米和纳米结构表面的固体药物剂型和微米和纳米结构的药物剂型

    公开(公告)号：US20140255482A9

    公开(公告)日：2014-09-11

    申请号：US12761993

    申请日：2010-04-16

    申请人： Stefan Klocke ,  Harald Walter ,  Alexander Stuck

    发明人： Stefan Klocke ,  Harald Walter ,  Alexander Stuck

    IPC分类号： A61K9/20

    CPC分类号： A61K9/2072 ,  A61J3/007

    摘要： A solid pharmaceutical dosage form [19] has micro- or nanostructures [10a, 10b, 10c, 10d] impressed on the surface thereof or an interface thereof. The dosage form [19] includes a suitable quantity and distribution of ingredients, such as one or more dyes, so as to enhance the optical contrast effect, C, caused by the micro- or nanostructures so that the micro- or nanostructures are observable by the human eye and thereby able to provide anti-counterfeiting characteristics to the dosage form.

    摘要翻译： 固体药物剂型[19]具有在其表面或其界面上施加的微观或纳米结构[10a，10b，10c，10d]。 剂型[19]包括适当的成分数量和分布，例如一种或多种染料，以增强由微结构或纳米结构引起的光学对比效应C，使得微观或纳米结构可被 人眼，从而能够向剂型提供防伪特征。

    PYRAZOL-4-YL CARBOXAMIDE DERIVATIVES AS MICROBIOCIDES
    9.
    发明申请
    PYRAZOL-4-YL CARBOXAMIDE DERIVATIVES AS MICROBIOCIDES 有权
    PYRAZOL-4-YL羧酰胺衍生物作为微生物

    公开(公告)号：US20130281505A1

    公开(公告)日：2013-10-24

    申请号：US13978482

    申请日：2012-01-02

    申请人： Daniel Stierli ,  Harald Walter

    发明人： Daniel Stierli ,  Harald Walter

    IPC分类号： A01N43/56 ,  C07D409/12 ,  C07D405/12 ,  C07D231/14 ,  C07D231/16

    CPC分类号： A01N43/56 ,  A61K31/415 ,  A61K31/4155 ,  C07D231/14 ,  C07D231/16 ,  C07D405/12 ,  C07D409/12

    摘要： Compounds of formula (I) wherein R1 is C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy; R2 is C1-C4alkyl; R3 is hydrogen or halogen; R4 is hydrogen, C1-C4alkyl or C1-C4halogenalkyl; R5 is hydrogen, halogen or C1-C4alkyl; R6 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl or C3-C6alkynyl; R7 is hydrogen, halogen, C1-C6alkyl, C2-C6alkenyl, C3-C6alkynyl, C3-C6cycloalkyl-C3-C6alkynyl, C1-C6haloalkyl, C1-C6haloalkoxy, C2-C6haloalkenyl, or C2-C6haloalkenyloxy; R5 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl, C3-C6alkynyl, amino, C1-C6alkylcarbonylamino, C1-C6alkoxycarbonylamino or C3-C6cycloalkylcarbonylamino; R9 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy, C2-C6alkenyl, C3-C6alkynyl, C3-C6cycloalkyl-C3-C6alkynyl, halophenoxy, halophenyl, C1-C6haloalkyl, C1-C6haloalkoxy, C2-C6haloalkenyl, or C2-C6haloalkenyloxy; R10 is hydrogen, halogen, C1-C4alkyl, C1-C6alkoxy, C2-C6alkenyl or C3-C6alkynyl; X is CH2, O or S; n is 0, 1 or 2; and agronomically acceptable salts/isomers/structural isomers/stereoisomers/diastereoisomers/enantiomers/tautomers and N-oxides of those compounds, are suitable for use as microbiocides.

    摘要翻译： 其中R1是C1-C4烷基，C1-C4卤代烷基或C1-C4烷氧基的式（Ⅰ）化合物; R2是C1-C4烷基; R3是氢或卤素; R4是氢，C1-C4烷基或C1-C4卤代烷基; R5是氢，卤素或C1-C4烷基; R6是氢，卤素，C1-C4烷基，C2-C6链烯基或C3-C6炔基; R 7是氢，卤素，C 1 -C 6烷基，C 2 -C 6烯基，C 3 -C 6炔基，C 3 -C 6环烷基-C 3 -C 6炔基，C 1 -C 6卤代烷基，C 1 -C 6卤代烷氧基，C 2 -C 6卤代烯基或C 2 -C 6卤代烯氧基; R 5是氢，卤素，C 1 -C 4烷基，C 2 -C 6烯基，C 3 -C 6炔基，氨基，C 1 -C 6烷基羰基氨基，C 1 -C 6烷氧基羰基氨基或C 3 -C 6环烷基羰基氨基; R 9是氢，卤素，C 1 -C 6烷基，C 1 -C 6烷氧基，C 2 -C 6烯基，C 3 -C 6炔基，C 3 -C 6环烷基-C 3-C 6炔基，卤代苯氧基，卤代苯基，C 1 -C 6卤代烷基，C 1 -C 6卤代烷氧基，C 2 -C 6卤代烯基或C 2 -C 6卤代烯氧基 ; R 10是氢，卤素，C 1 -C 4烷基，C 1 -C 6烷氧基，C 2 -C 6烯基或C 3 -C 6炔基; X是CH 2，O或S; n为0,1或2; 并且这些化合物的农学上可接受的盐/异构体/结构异构体/立体异构体/非对映异构体/对映体/互变异构体和N-氧化物适合用作杀微生物剂。

    PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES
    10.
    发明申请
    PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES 有权
    吡咯并吡啶衍生物及其作为微生物使用

    公开(公告)号：US20130072535A1

    公开(公告)日：2013-03-21

    申请号：US13700706

    申请日：2011-05-12

    申请人： Daniel Stierli ,  Harald Walter

    发明人： Daniel Stierli ,  Harald Walter

    IPC分类号： A61K31/415 ,  C07D231/14 ,  C07C239/20 ,  C07D231/16 ,  C07D231/10

    CPC分类号： C07D231/14 ,  A01N43/56 ,  C07C239/20 ,  C07D231/16

    摘要： Compounds of Formula (I) wherein R1 is C1-C4alkyl or C1-C4 haloalkyl; R2 is C1-C4alkyl; R3 is hydrogen or halogen; R4 is hydrogen, C1-C4alkyl or C1-C4halogenalkyl; R5 is hydrogen, halogen, C1-C4alkyl or C1-C4halogenalkyl; R6 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl or C3-C6alkinyl; R7 is hydrogen, halogen, C1-C6alkyl, C2-C6alkenyl, C3-C6alkinyl, C3-C6cycloalkyl-C3-C6alkinyl, halophenoxy, halophenyi, C1-C6haloalkyl, C1-C6haloakoxy, C2-C6haloalkenyl, or C2-C6haloalkenyloxy; R8 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl or C3-C6alkinyl; with the provisio that at least one of R6, R7 and R8 is different from hydrogen; n is 0 or 1, are suitable for use as microbriocides.

    摘要翻译： 式（I）的化合物，其中R 1是C 1 -C 4烷基或C 1 -C 4卤代烷基; R2是C1-C4烷基; R3是氢或卤素; R4是氢，C1-C4烷基或C1-C4卤代烷基; R5是氢，卤素，C1-C4烷基或C1-C4卤代烷基; R 6是氢，卤素，C 1 -C 4烷基，C 2 -C 6烯基或C 3 -C 6炔基; R 7是氢，卤素，C 1 -C 6烷基，C 2 -C 6烯基，C 3 -C 6炔基，C 3 -C 6环烷基-C 3 -C 6炔基，卤代苯氧基，卤代苯基，C 1 -C 6卤代烷基，C 1 -C 6卤代烷氧基，C 2 -C 6卤代烯基或C 2 -C 6卤代烯氧基; R8是氢，卤素，C1-C4烷基，C2-C6链烯基或C3-C6炔基; 条件是R6，R7和R8中的至少一个不同于氢; n为0或1，适用于微生物。