公开(公告)号：US11944540B2

公开(公告)日：2024-04-02

申请号：US17013495

申请日：2020-09-04

申请人： University of Maryland, Baltimore ,  Harpoon Medical, Inc.

发明人： Michael Nicholas D'ambra ,  Felino V. Cortez, Jr. ,  James S. Gammie ,  Peter Wilson ,  Stephen Epstein ,  Stephen Cournane ,  Julie Marie Etheridge ,  Peter Boyd

IPC分类号： A61F2/24

CPC分类号： A61F2/2466 ,  A61F2/2457 ,  A61F2/2463 ,  A61F2/2487 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2445 ,  A61F2/2451 ,  A61F2/246

摘要： Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The delivery devices can be configured to be actuated to form a distal anchor made of a pre-formed knot. The delivery devices deliver the pre-formed knot in an elongate configuration. Actuation of the delivery device causes the pre-formed knot to transition from the elongate configuration to the deployed configuration by approximating opposite ends of a suture coupled to a coiled configuration to form one or more loops. After formation of the knot, the delivery device can be withdrawn.

公开(公告)号：US11026672B2

公开(公告)日：2021-06-08

申请号：US16012195

申请日：2018-06-19

申请人： Harpoon Medical, Inc. ,  University of Maryland, Baltimore

发明人： William Niland ,  Felino V. Cortez, Jr. ,  James S. Gammie ,  Michael Nicholas D'ambra ,  Peter Wilson ,  Stephen Cournane

IPC分类号： A61B17/04 ,  A61B17/00 ,  A61F2/24 ,  A61B17/34

摘要： Described herein are methods and apparatus for approximating targeted tissue by intertwining two or more sutures together. The sutures are attached to the targeted tissue and routed to a twister device. The twister device secures end portions of the sutures and twists them to intertwine the sutures. Controlling the number of twists provides control over the forces applied to the targeted tissue. In conjunction with visualization feedback, real-time adjustments can be made to achieved targeted results, such as elimination of mitral regurgitation when the disclosed methods and apparatus are applied to mitral valve repair.

公开(公告)号：US10765515B2

公开(公告)日：2020-09-08

申请号：US15950458

申请日：2018-04-11

申请人： University of Maryland, Baltimore ,  Harpoon Medical, Inc.

发明人： Michael Nicholas D'ambra ,  Felino V. Cortez, Jr. ,  James S. Gammie ,  Peter Wilson ,  Stephen Epstein ,  Stephen Cournane ,  Julie Marie Etheridge ,  Peter Boyd

IPC分类号： A61F2/24

摘要： Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The anchor points of the artificial chordae can be offset from the apex of the heart to achieve a targeted force vector on the annulus. In addition, some embodiments include distal anchors implanted in the posterior leaflet in addition to those at the posterior annulus. This allows differential tensioning to be applied to provide for greater flexibility in treating various configurations of mitral valves to improve coaptation.

公开(公告)号：US11065120B2

公开(公告)日：2021-07-20

申请号：US16167069

申请日：2018-10-22

申请人： University of Maryland, Baltimore ,  Harpoon Medical, Inc.

发明人： Felino V. Cortez, Jr. ,  James S. Gammie ,  Peter Wilson ,  Luke Anthony Zanetti ,  Julie Marie Etheridge ,  Stephen Cournane

IPC分类号： A61F2/24 ,  A61B17/04 ,  A61B17/00 ,  A61B90/00

摘要： Described herein are methods and apparatus for approximating targeted tissue using locking sutures. The locking sutures can be configured to receive suture ends that are interweaved through portions of the locking sutures. In a pre-deployment configuration, a locking suture can slide along suture tails and can be positioned at a target location within a target region. Once a desired position and/or tension is achieved, the locking suture can be transitioned to a post-deployment configuration where the locking suture constricts around the suture tails to inhibit relative movement between the suture tails and the locking suture.

公开(公告)号：US11833048B2

公开(公告)日：2023-12-05

申请号：US17379904

申请日：2021-07-19

申请人： University of Maryland, Baltimore ,  Harpoon Medical, Inc.

发明人： Felino V. Cortez, Jr. ,  James S. Gammie ,  Peter Wilson ,  Luke Anthony Zanetti ,  Julie Marie Etheridge ,  Stephen Cournane

IPC分类号： A61F2/24 ,  A61B17/04 ,  A61B17/00 ,  A61B90/00

CPC分类号： A61F2/2466 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0485 ,  A61B90/03 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/0406 ,  A61B2017/048 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61B2017/0474 ,  A61B2017/0477 ,  A61B2017/0496 ,  A61B2090/08021 ,  A61F2/2445 ,  A61F2/2457

摘要： Described herein are methods and apparatus for approximating targeted tissue using locking sutures. The locking sutures can be configured to receive suture ends that are interweaved through portions of the locking sutures. In a pre-deployment configuration, a locking suture can slide along suture tails and can be positioned at a target location within a target region. Once a desired position and/or tension is achieved, the locking suture can be transitioned to a post-deployment configuration where the locking suture constricts around the suture tails to inhibit relative movement between the suture tails and the locking suture.