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公开(公告)号：US5399669A
公开(公告)日：1995-03-21
申请号：US96842
申请日：1993-07-26
申请人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
发明人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： Recombinantly produced interleukin-2 exhibits human IL-2 activity, has a molecular weight of about 15,000 daltons, is activity stable at a pH of 2-9 and is resistant to elevated temperatures. The recombinant IL-2 has the principal biological activity of human IL-2, promotion of proliferation of cytotoxic T lymphocytes.
摘要翻译： 重组产生的白细胞介素-2显示人IL-2活性，分子量约为15,000道尔顿，在2-9的pH下是活性稳定的并且耐高温。 重组IL-2具有人IL-2的主要生物活性，促进细胞毒性T淋巴细胞增殖。
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2.发明授权Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell 失效用于白细胞介素-2多肽的基因，携带所述基因的重组DNA，具有重组DNA的活细胞系，以及使用所述细胞产生白细胞介素-2的方法
公开(公告)号：US5795777A
公开(公告)日：1998-08-18
申请号：US621097
申请日：1996-03-22
申请人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
发明人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is trans-formed to produce interleukin-2.
摘要翻译： 分离编码具有白细胞介素-2的多肽的基因，并与载体DNA连接，该载体DNA能够在原核或真核细胞中在载体中的启动子基因下游位置复制获得重组DNA， 细胞被转化以产生白细胞介素-2。
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公开(公告)号：US5514567A
公开(公告)日：1996-05-07
申请号：US400179
申请日：1995-03-06
IPC分类号： C07K14/565 , C12P21/04 , C12N15/00
CPC分类号： C07K14/565
摘要： Disclosed is a recombinant plasmid having a gene which encompasses at least the entire coding region of human fibroblast interferon messenger RNA and a method for preparing such plasmid.
摘要翻译： 公开了具有包含人成纤维细胞干扰素信使RNA的至少整个编码区的基因的重组质粒和制备该质粒的方法。
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4.发明授权Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell 失效用于白细胞介素-2多肽的基因，携带所述基因的重组DNA，具有重组DNA的活细胞系，以及使用所述细胞产生白细胞介素-2的方法
公开(公告)号：US4738927A
公开(公告)日：1988-04-19
申请号：US463496
申请日：1983-02-03
申请人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
发明人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
IPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , C12N1/00 , C07H21/04 , C07K13/00 , C12N1/16 , C12N1/18 , C12N1/20 , C12N5/00 , C12N5/02 , C12N15/00 , C12P19/34 , C12P21/00 , C12P21/02 , C12P21/04 , C12R1/19
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： A gene coded for a polypeptide which possesses interleukin-2 activity is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.
摘要翻译： 分离编码具有白细胞介素-2活性的多肽的基因，并与载体DNA连接，该载体DNA能够在原核或真核细胞中在载体中的启动子基因下游的位置复制获得重组DNA， 转化细胞以产生白介素-2。
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公开(公告)号：US09376478B1
公开(公告)日：2016-06-28
申请号：US08463757
申请日：1995-06-05
IPC分类号： C07K14/565
CPC分类号： C07K14/565
摘要： Disclosed is a recombinant plasmid having a gene which encompasses at least the entire coding region of human fibroblast interferon messenger RNA and a method for preparing such plasmid.
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6.发明授权Gene encoding interleukin-2 polypeptide, recombinant DNA carrying the gene, a living cell line possessing the recombinant DNA and method for producing interleukin-2 using the cell 失效基因编码白细胞介素-2多肽，携带该基因的重组DNA，具有该重组DNA的活细胞系和使用该细胞产生白细胞介素-2的方法
公开(公告)号：US5795769A
公开(公告)日：1998-08-18
申请号：US516563
申请日：1995-08-18
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.
摘要翻译： 分离编码具有白细胞介素-2的多肽的基因，并与载体DNA连接，该载体DNA能够在原核或真核细胞中在载体中的启动子基因下游位置复制获得重组DNA， 转化细胞以产生白介素-2。
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公开(公告)号：US5700913A
公开(公告)日：1997-12-23
申请号：US331146
申请日：1994-10-28
申请人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
发明人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
CPC分类号： C07K14/55
摘要： Recombinant human Interleukin-2 (IL-2) polypeptides are provided. The polypeptides are produced by expression of suitable nucleic acid molecules in transformed host cells such as E. coli.
摘要翻译： 提供重组人白介素-2（IL-2）多肽。 通过在转化的宿主细胞如大肠杆菌中表达合适的核酸分子来产生多肽。
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8.发明授权Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell 失效用于白细胞介素-2多肽的基因，携带所述基因的重组DNA，具有重组DNA的活细胞系，以及使用所述细胞产生白细胞介素-2的方法
公开(公告)号：US5620868A
公开(公告)日：1997-04-15
申请号：US814049
申请日：1991-12-26
申请人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
发明人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima , Junji Hamuro
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.
摘要翻译： 分离编码具有白细胞介素-2的多肽的基因，并与载体DNA连接，该载体DNA能够在原核或真核细胞中在载体中的启动子基因下游位置复制获得重组DNA， 转化细胞以产生白介素-2。
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公开(公告)号：US5326859A
公开(公告)日：1994-07-05
申请号：US201359
申请日：1980-10-27
IPC分类号： C07K14/565 , C12N15/22 , C12N15/00
CPC分类号： C07K14/565
摘要： Disclosed is a recombinant plasmid having a gene which encompasses at least the entire coding region of human fibroblast interferon messenger RNA and a method for preparing such plasmid.
摘要翻译： 公开了具有包含人成纤维细胞干扰素信使RNA的至少整个编码区的基因的重组质粒和制备该质粒的方法。
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10.发明授权Human gamma interferon polypeptide having glutamine as the ninth n-terminal amino acid 失效具有谷氨酰胺作为第九个n末端氨基酸的人γ-干扰素多肽
公开(公告)号：US4835256A
公开(公告)日：1989-05-30
申请号：US129924
申请日：1987-12-03
IPC分类号： C07K14/57
CPC分类号： C07K14/57 , Y10S435/811 , Y10S930/142
摘要： Disclosed is a novel DNA which shows complementarity to human interferon-.gamma. mRNA, a recombinant plasmid containing the DNA, a microorganism containing the recombinant plasmid and a method of producing the same as well as a process for producing a polypeptide having human interferon.gamma. activity using the microorganism.
摘要翻译： 公开了显示与人类干扰素-γmRNA的互补性的新型DNA，含有该DNA的重组质粒，含有该重组质粒的微生物及其制备方法以及使用以下方法制备具有人干扰素γ活性的多肽的方法： 微生物。
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