公开(公告)号：US20070059363A1

公开(公告)日：2007-03-15

申请号：US10562379

申请日：2004-06-25

申请人： Hee Lee ,  Sung Kim ,  Jung Kim ,  Ji Lee ,  Young Jung ,  Jun Kim ,  Yun Seo ,  Ho-Il Choi ,  Seung Chang ,  Kee Park

发明人： Hee Lee ,  Sung Kim ,  Jung Kim ,  Ji Lee ,  Young Jung ,  Jun Kim ,  Yun Seo ,  Ho-Il Choi ,  Seung Chang ,  Kee Park

IPC分类号： A61K38/17 ,  A61K9/22

CPC分类号： A61K9/1694 ,  A61K9/1647 ,  A61K9/5084 ,  A61K38/24

摘要： Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by preparing the mixed formulation of sustained release microspheres with different compositions by a continuous one-step process by continuously introducing the mixed fluids into a dryer from the two or more different fluids for preparation of sustained release microspheres containing a biodegradable polymer, a drug, an additive and a solvent with different types of contents or both of the components, by controlling the mixing ratios of the fluids according to the time, unlike a conventional method including spray-drying a mixture of microspheres containing a biodegradable polymer, a drug, an additive and a solvent with a single composition. The present method can achieve a desired drug release, which is difficult to be obtained by conventional microspheres with a single composition, by preparing microspheres by a continuous one-step process, and can simplify the conventional complex process of separately preparing several microsphere formulations and then mixing the formulations at a proper ratio to achieve a desired drug release.

摘要翻译： 公开了通过连续一步法制备具有各种组成的缓释微球混合制剂的方法。 本发明的方法的特征在于通过连续一步法制备具有不同组成的缓释微球的混合制剂，通过从两种或更多种不同的流体连续引入混合流体到干燥器中，用于制备含有可生物降解聚合物的缓释微球 ，药物，添加剂和具有不同类型含量的溶剂或两种组分的溶剂通过控制流体的混合比而不同于常规方法，包括喷雾干燥含有可生物降解的聚合物的微球体的混合物， 药物，添加剂和具有单一组成的溶剂。 本发明方法可以通过连续一步法制备微球，实现通过具有单一组成的常规微球难以获得的所需药物释放，并且可以简化分别制备几种微球制剂的常规复合方法，然后 以适当的比例混合制剂以实现期望的药物释放。

公开(公告)号：US20070275082A1

公开(公告)日：2007-11-29

申请号：US10570564

申请日：2004-09-03

申请人： Hee Lee ,  Sung Kim ,  Jung Kim ,  Young Jung ,  Jung Kim ,  Ho Choi ,  Seung Chang ,  Kee Park

发明人： Hee Lee ,  Sung Kim ,  Jung Kim ,  Young Jung ,  Jung Kim ,  Ho Choi ,  Seung Chang ,  Kee Park

IPC分类号： A61K38/09 ,  A61K9/16

CPC分类号： A61K9/1647 ,  A61K9/1682 ,  A61K9/1694 ,  A61K38/09

摘要： Disclosed is a method of preparing sustained release microspheres by spray-drying liquids with different compositions for preparation the sustained release microspheres through an ultrasonic dual-feed nozzle. Unlike conventional methods of preparing sustained release microspheres by spray-drying a single liquid containing a biodegradable polymer, a drug, an additive and a solvent through a single-feed nozzle, the present method is characterized by simultaneously spray-drying two liquids with different compositions for preparation of the sustained release microspheres respectively through internal and external channels of an ultrasonic dual-feed nozzle to coat sprayed droplets through the internal channel with other sprayed droplets through the external channel. The present method is effective in achieving a low initial release and a desired continuous release.

摘要翻译： 公开了一种通过喷雾干燥具有不同组成的液体制备缓释微球的方法，用于通过超声波双重给料喷嘴制备缓释微球。 与通过单一进料喷嘴喷雾干燥含有可生物降解的聚合物，药物，添加剂和溶剂的单一液体制备缓释微球体的常规方法不同，本方法的特征在于同时喷雾干燥具有不同组成的两种液体 分别通过超声双馈喷嘴的内部和外部通道制备缓释微球，通过内部通道将喷雾的液滴通过外部通道与其他喷雾液滴一起涂覆。 本发明的方法在实现低的初始释放和期望的连续释放方面是有效的。

公开(公告)号：US20050208334A1

公开(公告)日：2005-09-22

申请号：US11084021

申请日：2005-03-21

申请人： Kyung Lee ,  Jeong Seo ,  Hyun Jeong ,  Chun Park ,  Jung Kim ,  Sung Kim

发明人： Kyung Lee ,  Jeong Seo ,  Hyun Jeong ,  Chun Park ,  Jung Kim ,  Sung Kim

IPC分类号： H01L51/50 ,  C09K11/06 ,  H01L51/00 ,  H05B33/14 ,  H05B33/12

CPC分类号： C09K11/06 ,  C09B57/008 ,  C09B57/02 ,  C09B57/10 ,  C09K2211/1014 ,  H01L51/0035 ,  H01L51/0059 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0067 ,  H01L51/0069 ,  H01L51/0071 ,  H01L51/0073 ,  H01L51/0081 ,  H01L51/5048 ,  H01L51/5088 ,  H01L2251/308 ,  H05B33/14 ,  Y10S428/917

摘要： An organic electroluminescence device is disclosed, to realize improvement of luminance and decrease on driving voltage, which includes an anode, a hole injecting layer, a hole transport layer, an emitting layer, and a cathode, wherein, the hole injecting layer and the hole transport layer are formed of the material expressed by the following chemical formula 1:

摘要翻译： 公开了一种有机电致发光器件，用于实现包括阳极，空穴注入层，空穴传输层，发光层和阴极在内的亮度的提高和驱动电压的降低，其中，空穴注入层和孔 传输层由以下化学式1表示的材料形成：

公开(公告)号：US20070192407A1

公开(公告)日：2007-08-16

申请号：US11587064

申请日：2004-11-03

申请人： Sung Kim ,  Jung Kim

发明人： Sung Kim ,  Jung Kim

IPC分类号： G06F15/16

CPC分类号： H04L12/5692 ,  H04L41/024

摘要： The present invention relates to an apparatus and method for executing provisioning in which integrally supervises and executes call information from a plurality of providers for providing particular services being connected to a server. This invention is comprised of a provisioning database, a client interface, a provisioning database interface, and a provider interface.

摘要翻译： 本发明涉及一种用于执行供应的装置和方法，其中整合地监视并执行来自多个供应商的呼叫信息，以提供连接到服务器的特定服务。 本发明包括配置数据库，客户端接口，配置数据库接口和提供者接口。

公开(公告)号：US20060092825A1

公开(公告)日：2006-05-04

申请号：US11115585

申请日：2005-04-26

申请人： Jung Kim ,  Jae Lee ,  Jung Kim

发明人： Jung Kim ,  Jae Lee ,  Jung Kim

IPC分类号： H04J11/00

CPC分类号： H04L25/03866 ,  H04L1/0059 ,  H04L1/0071 ,  H04L27/2601

摘要： An OFDM transmission apparatus having minimal transmission delay comprises a training symbol storage and generation unit, a delay unit and a controller. The training symbol storage and generation unit stores training symbols for the preamble, and outputs the stored training symbols when a training symbol output request signal is received. The delay unit receives data for the signal field from the MAC layer, delays the received data by the data processing time of the scrambler, and outputs the delayed data to the convolution encoder. The controller outputs the training symbol output request signal, requesting the preamble of the frame, to the training symbol storage and generation unit when a frame transmission request is received from the MAC layer, and outputs a data request signal, requesting the signal field and the data field, to the MAC layer in consideration of total data processing time (TPROCESS).

摘要翻译： 具有最小传输延迟的OFDM发送装置包括训练符号存储和生成单元，延迟单元和控制器。 训练符号存储和生成单元存储用于前导码的训练符号，并且当接收到训练符号输出请求信号时，输出存储的训练符号。 延迟单元接收来自MAC层的信号字段的数据，将接收的数据延迟加扰器的数据处理时间，并将延迟的数据输出到卷积编码器。 当从MAC层接收到帧发送请求时，控制器向训练符号存储和生成单元输出请求帧的前导码的训练符号输出请求信号，并输出请求信号字段和 数据字段，考虑总数据处理时间（T＆lt; PROCESS＆lt; / SUB＆gt;）到MAC层。

公开(公告)号：US20080064065A1

公开(公告)日：2008-03-13

申请号：US11781243

申请日：2007-07-21

申请人： Jung Kim ,  Jung Kim ,  Tae Kim ,  Jong Lee ,  Jong Yook

发明人： Jung Kim ,  Jung Kim ,  Tae Kim ,  Jong Lee ,  Jong Yook

IPC分类号： C12N1/20 ,  C12N15/00 ,  C12P21/06

CPC分类号： C07K14/51 ,  C07K2319/10 ,  C07K2319/21 ,  C12N15/62

摘要： Non-activated tissue-regeneration polypeptides (TRPs) and their preparation methods are disclosed. The TRPs include: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be mass-produced by cultured bacteria, such as recombinant E. coli, are in a non-activated state before in vivo administration, and their separation, purification, handling, storage and administration are simple and convenient. The in vivo administration of the TRPs is useful to stimulate the formation or regeneration of tissues, such as bones or cartilages, or to improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisms completely different from those of prior rhBMPs or TGF-β proteins.

摘要翻译： 公开了非活化组织再生多肽（TRP）及其制备方法。 TRP包括：蛋白转导结构域（PTD），其使多肽渗透到没有细胞膜受体的细胞膜上; 具有至少一个蛋白质转换酶切割位点的弗林蛋白酶激活结构域（FAD），其可被前蛋白转化酶切割并激活细胞中的组织再生结构域（TRD）; 和组织再生结构域（TRD），其可以通过FAD的蛋白质转化酶切割来激活以刺激组织的生长或形成或诱导组织的再生。 TRP可以通过培养的细菌如重组大肠杆菌大量生产，在体内给药之前处于非活化状态，其分离，纯化，处理，储存和给药简单方便。 TRP的体内施用可用于刺激组织如骨骼或软骨的形成或再生，或通过与这些完全不同的药理学机制来改善器官（例如肾，肝，肺和心脏）的纤维化和肝硬化。 的先前的rhBMP或TGF-β蛋白。

公开(公告)号：US20070105762A1

公开(公告)日：2007-05-10

申请号：US10560329

申请日：2005-11-02

申请人： Jung Kim ,  Jung Kim ,  Tae Kim ,  Jong Lee ,  Jong Yook

发明人： Jung Kim ,  Jung Kim ,  Tae Kim ,  Jong Lee ,  Jong Yook

IPC分类号： A61K38/17 ,  C07K14/475 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/51

摘要： Non-activated tissue-regeneration polypeptides (TRPs) and the preparation methods thereof are disclosed. The TRPs contain: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be practically mass-produced by the culture of bacteria, such as recombinant E. coli, and are in a non-activated state before in vivo administration. Thus, their production cost is only a few tenths of the prior active proteins having uses similar thereto, and processes for their separation, purification, handling, storage and administration are significantly simple and convenient. The in vivo administration of the TRPs can stimulate the formation or regeneration of tissues, such as bones or cartilages, or improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisims completely different from those of prior rhBMPs or TGF-β proteins. Accordingly, the TRPs will be useful as drugs having new mechanisms.

摘要翻译： 公开了非活化组织再生多肽（TRP）及其制备方法。 TRP包含：蛋白转导结构域（PTD），其使多肽渗透到没有细胞膜受体的细胞膜上; 具有至少一个蛋白质转换酶切割位点的弗林蛋白酶激活结构域（FAD），其可被前蛋白转化酶切割并激活细胞中的组织再生结构域（TRD）; 和组织再生结构域（TRD），其可以通过FAD的蛋白质转化酶切割来激活以刺激组织的生长或形成或诱导组织的再生。 TRP可以通过细菌的培养物，如重组大肠杆菌，实际上大量生产，并且在体内给药之前处于非活化状态。 因此，它们的生产成本只是其相似用途的现有活性蛋白质的十分之一，其分离，纯化，处理，储存和给药的方法显而易见。 TRP的体内施用可以刺激组织如骨骼或软骨的形成或再生，或通过与以前的rhBMP完全不同的药理学机制改善器官（例如肾脏，肝脏，肺和心脏）的纤维化和肝硬化 或TGF-β蛋白。 因此，TRP将作为具有新机制的药物是有用的。

公开(公告)号：US09131918B2

公开(公告)日：2015-09-15

申请号：US12727019

申请日：2010-03-18

申请人： Suk Jin Lee ,  Jung Kim

发明人： Suk Jin Lee ,  Jung Kim

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S7/52 ,  G01S15/89

CPC分类号： A61B8/00 ,  A61B8/463 ,  A61B8/483 ,  G01S7/52073 ,  G01S7/52074 ,  G01S15/8993

摘要： Embodiments for providing a plurality of 3-dimensional ultrasound images by using a plurality of volume slices in an ultrasound system are disclosed. The ultrasound system comprises: an ultrasound data acquisition unit configured to transmit and receive ultrasound signals to and from a target object to acquire ultrasound data; a volume data forming unit configured to form volume data by using the ultrasound data; a user input unit for allowing a user to input a user instruction; and a processing unit configured to set a plurality of volume slice regions having different widths in the volume data in response to the user instruction and form a plurality of 3-dimensional ultrasound images by using volume slices defined by the volume slice regions.

摘要翻译： 公开了通过在超声系统中使用多个体积片来提供多个3维超声图像的实施例。 所述超声波系统包括：超声数据获取单元，被配置为向目标物体发送超声波信号并从目标对象接收超声波信号以获取超声波数据; 体数据形成单元，被配置为通过使用所述超声数据来形成体数据; 用户输入单元，用于允许用户输入用户指令; 以及处理单元，被配置为响应于所述用户指令在所述体数据中设置具有不同宽度的多个体积切片区域，并且通过使用由所述体积切片区域定义的体积切片形成多个3维超声图像。

公开(公告)号：US08956298B2

公开(公告)日：2015-02-17

申请号：US12962289

申请日：2010-12-07

申请人： Suk Jin Lee ,  Jung Kim

发明人： Suk Jin Lee ,  Jung Kim

IPC分类号： A61B8/00 ,  G01S15/89 ,  A61B8/08 ,  G06T7/00 ,  G01S7/52 ,  A61B8/13

CPC分类号： G01S15/8993 ,  A61B8/085 ,  A61B8/13 ,  A61B8/469 ,  A61B8/5215 ,  A61B8/5253 ,  G01S7/52063 ,  G01S7/52071 ,  G01S7/52074 ,  G06T7/0012

摘要： Embodiments for providing an ultrasound spatial compound image are disclosed. In one embodiment, by way of non-limiting example, an ultrasound system comprises: an ultrasound data acquisition unit configured to transmit and receive ultrasound signals to and from a target object to output first ultrasound data and a plurality of sets of second ultrasound data corresponding to a region of interest (ROI); a user input unit configured to receive input information for defining the ROI; and a processing unit in communication with the ultrasound data acquisition unit and the user input unit, the processing unit being configured to form volume data based on the plurality of sets of second ultrasound data, compare the first ultrasound data with the volume data to detect geometric information therein, form a two-dimensional (2D) ultrasound image based on the first ultrasound data, and a first three-dimensional (3D) ultrasound image and a second 3D ultrasound data based on the volume data in consideration of the geometric information, and perform a spatial compound upon the 2D ultrasound image, the first 3D ultrasound image and the second 3D ultrasound image based on the geometric information to form an ultrasound spatial compound image.

摘要翻译： 公开了用于提供超声空间复合图像的实施例。 在一个实施例中，作为非限制性示例，超声系统包括：超声数据获取单元，被配置为向目标对象发送和接收超声信号以输出第一超声数据和对应于多个第二超声数据组 到感兴趣的区域（ROI）; 用户输入单元，被配置为接收用于定义ROI的输入信息; 以及与所述超声数据获取单元和所述用户输入单元通信的处理单元，所述处理单元被配置为基于所述多组第二超声数据形成体数据，将所述第一超声数据与所述体数据进行比较以检测所述几何 信息，基于第一超声数据形成二维（2D）超声图像，以及考虑到几何信息的基于体数据的第一三维（3D）超声图像和第二3D超声数据，以及 基于所述几何信息，在所述2D超声图像，所述第一3D超声图像和所述第二3D超声图像上执行空间化合物以形成超声空间复合图像。

公开(公告)号：US07777137B2

公开(公告)日：2010-08-17

申请号：US11702877

申请日：2007-02-05

申请人： Bum Mo Ahn ,  Ki Uk Kyung ,  Jung Kim ,  Dong Soo Kwon

发明人： Bum Mo Ahn ,  Ki Uk Kyung ,  Jung Kim ,  Dong Soo Kwon

IPC分类号： G06F3/046

CPC分类号： G06F3/016 ,  G09B21/004

摘要： The tactile transmission device includes a plurality of cells arranged at regular intervals, each having a storage space therein. A contact member is installed in each of the cells, an upper portion of the contact member protruding out of the cell. An elastic member is installed in each of the cells, and biases the contact member upwards. A sensor is installed in each of the cells, and measures displacement of the contact member. A magneto-rheological fluid is contained in each of the cells. A coil is installed in each of the cells and generates a magnetic field in the cell. A control means compares a shape information value of the image with a displacement value of the contact member output from the sensor, thus controlling a quantity of current applied to the coil. According to the present invention, the shape information of an image displayed on a screen is corrected to be suitable for a user's characteristics, thus more precisely transmitting the shape information on the screen to the user. Further, a transmission medium for transmitting a tactile sensation to a user has a simple construction, so that miniaturization of the tactile transmission device is very easily realized.

摘要翻译： 触觉传输装置包括以规则间隔布置的多个单元，每个单元在其中具有存储空间。 接触构件安装在每个单元中，接触构件的上部从单元突出。 弹性构件安装在每个单元中，并将接触构件向上偏压。 传感器安装在每个单元中，并且测量接触构件的位移。 磁流变流体包含在每个电池中。 线圈安装在每个电池中，并在电池中产生磁场。 控制装置将图像的形状信息值与从传感器输出的接触构件的位移值进行比较，从而控制施加到线圈的电流量。 根据本发明，将屏幕上显示的图像的形状信息修正为适合于用户的特性，从而更精确地将画面上的形状信息发送给用户。 此外，用于向用户发送触觉的传输介质具有简单的结构，使得触觉传输装置的小型化非常容易实现。