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    Implantable Drug Delivery Device with Bladder Retention Feature
    2.
    发明申请
    Implantable Drug Delivery Device with Bladder Retention Feature 有权
    具有膀胱保留特征的可植入药物输送装置

    公开(公告)号：US20120089121A1

    公开(公告)日：2012-04-12

    申请号：US13267469

    申请日：2011-10-06

    申请人： Heejin Lee ,  Hong Linh Ho Duc

    发明人： Heejin Lee ,  Hong Linh Ho Duc

    IPC分类号： A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0065 ,  A61K9/20 ,  A61K31/167 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/402 ,  A61M2210/1085

    摘要： Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder Which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.

    摘要翻译： 提供了用于受控药物递送的可植入装置和方法。 该装置包括可在保持形状和低轮廓形状之间变形的装置结构，用于展开在患者的膀胱中，并且具有容纳药物制剂的药物储存器腔。 该装置还包括浮力保持部分，其包括一定量的夹带空气或气体产生或泡腾粉末，其将在与膀胱中的尿液接触之后产生一定量的夹带空气。 浮力保持部分可以包括水可渗透的和/或可生物降解的壁，其可以在药物释放之后释放夹带的空气，以使得装置沉入膀胱颈部以促进装置排出而不需要装置取回医学程序。

    Implantable drug delivery device with bladder retention feature
    5.
    发明授权
    Implantable drug delivery device with bladder retention feature 有权
    具有膀胱保留功能的植入式药物输送装置

    公开(公告)号：US09457176B2

    公开(公告)日：2016-10-04

    申请号：US13267469

    申请日：2011-10-06

    申请人： Heejin Lee ,  Hong Linh Ho Duc

    发明人： Heejin Lee ,  Hong Linh Ho Duc

    IPC分类号： A61M31/00 ,  A61K9/00

    CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0065 ,  A61K9/20 ,  A61K31/167 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/402 ,  A61M2210/1085

    摘要： Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.

    摘要翻译： 提供了用于受控药物递送的可植入装置和方法。 该装置包括可在保持形状和低轮廓形状之间变形的装置结构，用于展开在患者的膀胱中，并且具有容纳药物制剂的药物储存器腔。 该装置还包括浮力保持部分，其包括一定量的夹带的空气或气体产生或泡腾的粉末，其将在与膀胱中的尿液接触之后产生一定量的夹带的空气。 浮力保持部分可以包括水可渗透的和/或可生物降解的壁，其可以在药物释放之后释放夹带的空气，以使得装置沉入膀胱颈部以促进装置排出而不需要装置取回医学程序。

    IMPLANTABLE DEVICE FOR CONTROLLED DISSOLUTION AND DIFFUSION OF LOW SOLUBILITY DRUG
    6.
    发明申请
    IMPLANTABLE DEVICE FOR CONTROLLED DISSOLUTION AND DIFFUSION OF LOW SOLUBILITY DRUG 有权
    用于控制溶解性和低溶解性药物扩散的可植入装置

    公开(公告)号：US20120203203A1

    公开(公告)日：2012-08-09

    申请号：US13366981

    申请日：2012-02-06

    申请人： Heejin Lee ,  Hong Linh Ho Duc ,  Matthew Sansone

    发明人： Heejin Lee ,  Hong Linh Ho Duc ,  Matthew Sansone

    IPC分类号： A61M31/00

    CPC分类号： A61K9/0024 ,  A61K9/0034 ,  A61K31/337 ,  A61K31/407 ,  A61K31/46 ,  A61K31/555 ,  A61K31/7064 ,  A61K33/24 ,  A61M31/002 ,  A61M37/0069 ,  A61M2210/1085 ,  A61M2210/1089

    摘要： Implantable drug delivery devices are provided that are deformable between a relatively straightened shape suitable for deployment and a retention shape suited to retain the device within the bladder or other body cavity. While in the body cavity, the devices release drug from solid drug units housed in the devices. The devices are designed to house the solid drug units in a way that exposes one or more sides of the solid drug units to the fluid at the in vivo site of deployment. Methods for using the devices for administering drug and making the devices also are provided.

    摘要翻译： 提供可植入药物递送装置，其可在适于展开的相对矫直形状和适于将装置保持在囊或其它体腔内的保持形状之间变形。 在体腔中，装置将药物从容纳在装置中的固体药物单元释放出来。 这些装置被设计成以固定药物单元的一侧或多侧将暴露在体内部位的液体的方式容纳固体药物单元。 还提供了使用用于给药的装置和制造装置的方法。

    Implantable drug delivery device and methods
    8.
    发明授权
    Implantable drug delivery device and methods 有权

    公开(公告)号：US10532132B2

    公开(公告)日：2020-01-14

    申请号：US13910730

    申请日：2013-06-05

    申请人： Irene Sophie Tobias ,  Heejin Lee ,  Michael J. Cima ,  Jordan Dimitrakov

    发明人： Irene Sophie Tobias ,  Heejin Lee ,  Michael J. Cima ,  Jordan Dimitrakov

    IPC分类号： A61L31/06 ,  A61L31/16

    摘要： A method is provided for local controlled delivery of a drug to the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of a patient in need of treatment. In one embodiment, the method includes implanting a resorbable drug delivery device within the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens of the patient. The drug delivery device may include an elastic device body housing at least one drug reservoir which contains at least one drug. In a preferred embodiment, the method further includes releasing the drug from the device in a controlled manner to, typically directly to, the seminal vesicle, the prostate, the ejaculatory duct, or the vas deferens.

    Implantable device with intravesical tolerability and methods of treatment
    9.
    发明授权
    Implantable device with intravesical tolerability and methods of treatment 有权
    具有膀胱内耐受性和治疗方法的植入式装置

    公开(公告)号：US08679094B2

    公开(公告)日：2014-03-25

    申请号：US12972364

    申请日：2010-12-17

    申请人： Michael J. Cima ,  Heejin Lee

    发明人： Michael J. Cima ,  Heejin Lee

    IPC分类号： A61K9/22

    CPC分类号： A61M31/002 ,  A61F2/042 ,  A61K9/0034 ,  A61K9/2072 ,  A61K31/00 ,  A61K31/167 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/402 ,  A61L2300/602 ,  A61L2430/22 ,  A61M31/00

    摘要： Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1 N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.

    摘要翻译： 提供了可以在需要治疗的患者的膀胱内完全展开并且被患者良好耐受的膀胱内装置。 该装置可以包括具有保持形状的弹性体，其具有（i）提供膀胱内移动性的尺寸并且防止医疗装置通过尿道的排尿，以及（ii）排除医疗装置进入的尺寸，浮力或两者 输尿管孔。 当压缩到任何尺寸为3cm的最大尺寸的形状时，弹性体可发挥小于1N的最大作用力。 该装置可以包括用于膀胱内控制释放的药物，用于膀胱或区域组织的治疗。 还提供了治疗方法，包括在膀胱中选择需要治疗的患者，其中治疗的耐受性是主要关注的。

    Solid drug tablets for implantable drug delivery devices
    10.
    发明授权
    Solid drug tablets for implantable drug delivery devices 有权
    用于可植入药物递送装置的固体药物片剂

    公开(公告)号：US08343516B2

    公开(公告)日：2013-01-01

    申请号：US12825238

    申请日：2010-06-28

    申请人： Karen Danielle Daniel ,  Burleigh M. Hutchins, III ,  Cheryl Larrivee-Elkins ,  Heejin Lee

    发明人： Karen Danielle Daniel ,  Burleigh M. Hutchins, III ,  Cheryl Larrivee-Elkins ,  Heejin Lee

    IPC分类号： A61F13/00 ,  A61F2/02

    CPC分类号： A61K9/0004 ,  A61K9/0034 ,  A61K9/2004 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2072 ,  A61K9/2095 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61M31/002 ,  A61M31/007 ,  A61M2202/06 ,  B65B1/16

    摘要： A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another.

    摘要翻译： 以固体片剂的形式提供药物剂型，其大于当量麻醉剂的50重量％。 局部麻醉剂可以选自氨基酰胺，氨基酯及其组合。 药片可以是大于70重量％的药物的微型片剂，其余为赋形剂。 例如，麻醉剂可以包括盐或碱形式的利多卡因，与粘合剂和润滑剂赋形剂组合。 还提供了包括片剂在内的可植入药物递送装置，例如药物片剂中的一种或多种可以包含在生物相容的壳体中。 药物片剂可以是具有平坦端面的大致圆柱形，并且该装置可以具有在壳体中对齐的10至100个药物片剂，相邻片剂的平坦端面彼此邻接。