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公开(公告)号：US07521457B2
公开(公告)日：2009-04-21
申请号：US11206703
申请日：2005-08-17
申请人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jens Juergen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Karl Zahn , Lars Herfurth
发明人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jens Juergen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Karl Zahn , Lars Herfurth
IPC分类号： C07D239/42 , C07D239/46 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，W，X，Y，Z，Ra，Rb，Rc，R 1和R 3如权利要求1中所定义，其适用于治疗以过量 或异常细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。
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公开(公告)号：US20060148800A1
公开(公告)日：2006-07-06
申请号：US11206703
申请日：2005-08-17
申请人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Zahn , Lars Herfurth
发明人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Zahn , Lars Herfurth
IPC分类号： A61K31/53
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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3.发明授权公开(公告)号：US07569561B2
公开(公告)日：2009-08-04
申请号：US11675936
申请日：2007-02-16
申请人： Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Juergen Quant , Flavio Solca , Martin Steegmaier , Stephan Karl Zahn
发明人： Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Juergen Quant , Flavio Solca , Martin Steegmaier , Stephan Karl Zahn
IPC分类号： C07D403/12 , C07D413/12 , C07D498/04 , C07D487/04 , A61K31/551 , A61K31/553 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D498/04 , C07D403/12 , C07D413/12 , C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R6, X and Y are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, as well as the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 6，X和Y如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，以及其用于制备 具有上述性质的药物组合物。
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公开(公告)号：US07241769B2
公开(公告)日：2007-07-10
申请号：US11132091
申请日：2005-05-18
申请人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Karl Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
发明人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Karl Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
IPC分类号： C07D239/42 , C07D239/46 , A61K31/505 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12
摘要： The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，Y，Z，R a，O，R b，R c， R 1，R 2和R 3定义如权利要求1所述，其适用于治疗以过度或异常细胞为特征的疾病 增殖及其用于制备具有上述性质的药物组合物的用途。
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公开(公告)号：US20050261295A1
公开(公告)日：2005-11-24
申请号：US11132091
申请日：2005-05-18
申请人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
发明人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D253/08 , A61K31/506 , A61K31/53 , C07D43/02
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12
摘要： The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，Y，Z，R a，O，R b，R c， R 1，R 2和R 3定义如权利要求1所述，其适用于治疗以过度或异常细胞为特征的疾病 增殖及其用于制备具有上述性质的药物组合物的用途。
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公开(公告)号：US20070207999A1
公开(公告)日：2007-09-06
申请号：US11675936
申请日：2007-02-16
申请人： Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Quant , Flavio Solca , Martin Steegmaier , Stephan Zahn
发明人： Heinz Stadtmueller , Anke Baum , Guido Boehmelt , Harald Engelhardt , Jens Quant , Flavio Solca , Martin Steegmaier , Stephan Zahn
IPC分类号： A61K31/55 , A61K31/553 , C07D403/02 , C07D413/02
CPC分类号： C07D498/04 , C07D403/12 , C07D413/12 , C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R6, X and Y are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, as well as the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括其中R 1至R 6的通式（1）的化合物，X和Y如权利要求1中所定义，其适用于治疗疾病 其特征在于过度或异常的细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。
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7.发明授权Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions 有权二氢蝶啶酮，其制备方法及其作为药物组合物的用途公开(公告)号：US06861422B2
公开(公告)日：2005-03-01
申请号：US10374876
申请日：2003-02-26
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D295/073 , C07D475/00
摘要： The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的二氢蝶啶酮：其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法和用途 作为药物组合物。
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8.发明申请Intermediate Compounds for making Dihydropteridinones Useful as Pharmaceutical Compositions 有权用作制备二氢蝶呤的中间体化合物可用作药物组合物公开(公告)号：US20080171747A1
公开(公告)日：2008-07-17
申请号：US11941463
申请日：2007-11-16
申请人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求和说明书中给出的含义，其异构体，中间体和 制备这些二氢蝶啶酮的方法及其作为药物组合物的用途。
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公开(公告)号：US08003786B2
公开(公告)日：2011-08-23
申请号：US12873687
申请日：2010-09-01
申请人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky , Gisela Schnapp
发明人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky , Gisela Schnapp
IPC分类号： C07D475/00
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。
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公开(公告)号：US20080293944A1
公开(公告)日：2008-11-27
申请号：US12129728
申请日：2008-05-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： C07D241/04
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。
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