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    Modified TNF-alpha molecules, DNA encoding such and vaccines comprising such modified TNF-alpha and DNA
    1.
    发明授权
    Modified TNF-alpha molecules, DNA encoding such and vaccines comprising such modified TNF-alpha and DNA 失效
    修饰的TNF-α分子，编码这样的DNA和包含这种修饰的TNF-α和DNA的疫苗

    公开(公告)号：US07118750B1

    公开(公告)日：2006-10-10

    申请号：US09060294

    申请日：1998-04-15

    申请人： Martin Roland Jensen ,  Søren Mouritsen ,  Henrik Elsner ,  Iben Dalum

    发明人： Martin Roland Jensen ,  Søren Mouritsen ,  Henrik Elsner ,  Iben Dalum

    IPC分类号： A61K38/19 ,  C07K14/25

    CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K39/00 ,  C07K19/00 ,  C07K2319/00 ,  Y10S930/144

    摘要： A modified human TNFα molecule is capable of raising neutralizing antibodies towards unmodified human TNFα following administration of the modified TNFα to a human host, wherein one or more peptide fragments of the human TNFα molecule has been substituted by one or more peptides containing immunodominant T cell epitopes or a truncated form of the molecule containing the immunodominant epitope and one or both flanking regions of the human TNFα-molecule containing at least one TNFα B cell epitope, wherein the substitution introduces a substantial change in the amino acid sequence of any one of the strands of the front β-sheet, in any one of the connecting loops, or in any one of the B′, I, or D strands of the back β-sheet.

    摘要翻译： 在将修饰的TNFα施用于人宿主后，经修饰的人TNFα分子能够提供针对未修饰的人TNFα的中和抗体，其中人TNFα分子的一个或多个肽片段已被含有免疫优势T细胞表位的一种或多种肽取代 或包含免疫显性表位和含有至少一种TNFαb细胞表位的人TNFα分子的一个或两个侧翼区域的分子的截短形式，其中所述取代引入任何一条链的氨基酸序列的显着变化 在任何一个连接环中，或在背面β片中的任何一个B'，I或D链中的前β片。

    Article for tuesyl-activated dextran for solid-phase coupling
    2.
    发明授权
    Article for tuesyl-activated dextran for solid-phase coupling 失效
    用于固相偶联的甲酚激活葡聚糖的文章

    公开(公告)号：US06262256B1

    公开(公告)日：2001-07-17

    申请号：US09073646

    申请日：1998-05-06

    申请人： Henrik Elsner ,  Søren Mouritsen

    发明人： Henrik Elsner ,  Søren Mouritsen

    IPC分类号： C08B3702

    CPC分类号： C07K17/08 ,  C07K1/042 ,  C12N11/06 ,  G01N33/545 ,  G01N33/548

    摘要： A method of modifying the binding properties on a surface of a solid phase on which there are nucleophilic groups, which is characterized in that the surface is treated with a solution of an activated polysaccharide; a method of immobilizing a chemical compound to a solid phase on which there are immobilized activated polysaccharides, whereby the chemical compound is contacted with the surface of the solid phase the binding properties of which are modified by the method according to the invention; an article which is characterized in that to the surface thereof an activated polysaccharide is fixated, such as activated dextran or activated agarose, and use of this article for use in solid phase reactions, in solid phase assay, solid phase peptide synthesis, solid phase nucleotide synthesis, solid phase enzyme processing, and joining of biological surfaces.

    摘要翻译： 一种修饰在其上具有亲核基团的固相表面上的结合性质的方法，其特征在于表面用活化多糖的溶液处理; 将化合物固定在其上固定有活化多糖的固相的方法，由此化学化合物与固相的表面接触，其结合性质通过本发明的方法进行改性; 其特征在于，其活性多糖被固定，例如活化的葡聚糖或活化的琼脂糖，并使用该制品用于固相反应，固相测定，固相肽合成，固相核苷酸 合成，固相酶加工和生物表面的接合。

    Method of preparing tresyl-activated dextran, article having tresyl-activated dextran fixed covalently to its surface, and immobilization of chemical compounds thereto
    3.
    发明授权
    Method of preparing tresyl-activated dextran, article having tresyl-activated dextran fixed covalently to its surface, and immobilization of chemical compounds thereto 失效
    制备甲磺酰活化葡聚糖的方法，将具有固定在其表面上的甲磺酰活化的葡聚糖的化合物及其化合物固定化

    公开(公告)号：US5874569A

    公开(公告)日：1999-02-23

    申请号：US379675

    申请日：1995-03-22

    申请人： Henrik Elsner ,  S.o slashed.ren Mouritsen

    发明人： Henrik Elsner ,  S.o slashed.ren Mouritsen

    IPC分类号： G01N33/547 ,  C07K1/04 ,  C07K17/08 ,  C08J7/04 ,  C12N11/02 ,  C12N11/06 ,  G01N33/545 ,  G01N33/548 ,  C08B37/02

    CPC分类号： C07K17/08 ,  C07K1/042 ,  C12N11/06 ,  G01N33/545 ,  G01N33/548

    摘要： A method of preparing a tresyl-activated dextran is disclosed in which an aqueous solution of dissolved dextran is reacted with a tresylating agent in a hexamethylphosphoric triamide and/or N-methyl pyrrolidinone solvent, and the formed tresyl-activated dextran is recovered. A method of immobilizing a chemical compound to the surface of a solid phase having nucleophilic groups covalently bound or non-covalently bound is also disclosed, the method involving treating the surface with a solution of tresyl-activated dextran prepared as described above, and contacting the chemical compound with the treated surface. An article is also disclosed wherein tresy-activated dextran prepared as described above is fixed covalently to its surface.

    摘要翻译： PCT No.PCT / DK93 / 00259 Sec。 371日期：1995年3月22日 102（e）1995年3月22日PCT PCT 1993年8月10日PCT公布。 出版物WO94 / 03530 日本1994年2月17日公开了一种制备甲磺酰活化葡聚糖的方法，其中溶解的葡聚糖水溶液与六甲基磷酰三胺和/或N-甲基吡咯烷酮溶剂中的甲磺酸酯反应，形成的甲磺酰活化葡聚糖 被收回。 还公开了将化合物固定在具有共价结合或非共价结合的亲核基团的固相的表面的方法，该方法涉及用如上所述制备的甲酚激活的葡聚糖溶液处理表面，并使 化合物与处理过的表面。 还公开了如上所述制备的异源活化的葡聚糖与其表面共价固定的制品。

    Oncology drug innovation
    5.
    发明申请
    Oncology drug innovation 审中-公开
    肿瘤药物创新

    公开(公告)号：US20050037445A1

    公开(公告)日：2005-02-17

    申请号：US10482029

    申请日：2002-06-19

    申请人： Hans Poulsen ,  Nina Pedersen ,  Shila Mortensen ,  Susanne Sorensen ,  Mikkel Pedersen ,  Henrik Elsner

    发明人： Hans Poulsen ,  Nina Pedersen ,  Shila Mortensen ,  Susanne Sorensen ,  Mikkel Pedersen ,  Henrik Elsner

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/39 ,  A61K47/48 ,  A61K48/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/705 ,  C12N15/09 ,  C12N15/10 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574

    CPC分类号： G01N33/5011 ,  A61K38/00 ,  A61K39/00 ,  C12N15/1034 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q1/6897 ,  G01N33/57492 ,  G01N2500/20 ,  C12Q2527/125

    摘要： The present invention describes methods for identification of molecules expressed at a different level on the cell surface of cancer cells compared to non-malignant cells and methods of identification of cancer specific promoters to be used singly or in combination for delivery and expression of therapeutic genes for treatment of cancer. The invention furthermore describes targeting complexes targeted to cell surface molecules identified by the methods of the invention. In embodiments of the invention said targeting complexes comprise the promoters identified by the methods of the invention. In addition the invention describes methods of identifying binding partners for the cell surface molecules and the binding partners per se. Methods of treatment using the targeting complexes and uses of the targeting complexes for the preparation of a medicament arc also disclosed by the invention. Furthermore, the invention describes uses of the cell surface molecules or fragments thereof for preparation of vaccines.

    摘要翻译： 本发明描述了与非恶性细胞相比，用于鉴定在癌细胞的细胞表面上以不同水平表达的分子的方法以及用于单独使用或组合用于递送和表达治疗基因的癌症特异性启动子的鉴定方法 治疗癌症。 本发明进一步描述了靶向通过本发明方法鉴定的细胞表面分子的复合物。 在本发明的实施方案中，所述靶向复合物包含通过本发明的方法鉴定的启动子。 此外，本发明描述了鉴定细胞表面分子和结合配偶体本身的结合配偶体的方法。 本发明还公开了使用靶向复合物的治疗方法和靶向复合物用于制备药物电弧的用途。 此外，本发明描述了细胞表面分子或其片段用于制备疫苗的用途。