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1.发明授权Peptides with the marburg I polymorphism of factor VII-activating protease (FSAP) and their preparation and uses 有权多肽与Marburg I多态性因子VII活化蛋白酶（FSAP）及其制备和用途公开(公告)号：US07951910B2
公开(公告)日：2011-05-31
申请号：US12578337
申请日：2009-10-13
申请人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
发明人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
IPC分类号： C07K14/745
CPC分类号： C07K16/40 , Y10S530/806
摘要： The invention relates to peptides with the Marburg I polymorphism of FSAP and to their preparation and uses, in particular in therapy and diagnosis. The peptides are suitable for use as immunizing antigens for preparing FSAP MR I specific antibodies.
摘要翻译： 本发明涉及具有FSAP的Marburg I多态性的肽及其制备和用途，特别是在治疗和诊断中。 这些肽适合用作免疫抗原来制备FSAP MR I特异性抗体。
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2.发明授权Antibodies which are directed against the Marburg I polymorphism of factor VII-activating protease (FSAP), and their preparation and use 有权针对因子VII激活蛋白酶（FSAP）的Marburg I多态性的抗体及其制备和用途公开(公告)号：US07622558B2
公开(公告)日：2009-11-24
申请号：US11208881
申请日：2005-08-23
申请人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
发明人： Herbert Schwarz , Harald Althaus , Bodo Fischer , Thomas Wissel
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , Y10S530/806
摘要： The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized by the fact that they bind specifically to the FSAP MR I variant but not to the FSAP wild-type protein or other mutant variants which are characterized by amino acid substitutions at other positions in the FSAP protein.
摘要翻译： 本发明涉及针对FSAP Marburg I变体的抗体及其制备和用途，特别是在治疗和诊断中。 抗体的特征在于它们与FSAP MR I变体特异性结合，但不结合FSAP野生型蛋白或其它以FSAP蛋白中其他位置的氨基酸取代为特征的突变体。
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公开(公告)号：US20060045879A1
公开(公告)日：2006-03-02
申请号：US11208881
申请日：2005-08-23
申请人： Harald Althaus , Herbert Schwarz , Bodo Fischer , Thomas Wissel
发明人： Harald Althaus , Herbert Schwarz , Bodo Fischer , Thomas Wissel
IPC分类号： A61K39/395 , C07K16/40 , C07K7/08
CPC分类号： C07K16/40 , Y10S530/806
摘要： The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized by the fact that they bind specifically to the FSAP MR I variant but not to the FSAP wild-type protein or other mutant variants which are characterized by amino acid substitutions at other positions in the FSAP protein.
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公开(公告)号：US20120171697A1
公开(公告)日：2012-07-05
申请号：US13332441
申请日：2011-12-21
申请人： Andreas Kappel , Andreas Rechner , Sina Stephan , Thomas Wissel
发明人： Andreas Kappel , Andreas Rechner , Sina Stephan , Thomas Wissel
IPC分类号： G01N33/573 , G01N33/82
摘要： A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined.
摘要翻译： 确定样品中特别是直接凝血酶和因子Xa抑制剂的蛋白水解活性凝血因子（抗凝剂）抑制剂的均匀方法，以及用于该方法的测试试剂盒。 使用与蛋白水解活性凝血因子结合但不被后者切割并与抗凝血剂竞争的配体。
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公开(公告)号：US08889370B2
公开(公告)日：2014-11-18
申请号：US13332441
申请日：2011-12-21
申请人： Andreas Kappel , Andreas Rechner , Sina Stephan , Thomas Wissel
发明人： Andreas Kappel , Andreas Rechner , Sina Stephan , Thomas Wissel
摘要： A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined.
摘要翻译： 确定样品中特别是直接凝血酶和因子Xa抑制剂的蛋白水解活性凝血因子（抗凝剂）抑制剂的均匀方法，以及用于该方法的测试试剂盒。 使用与蛋白水解活性凝血因子结合但不被后者切割并与抗凝血剂竞争的配体。
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公开(公告)号：US07700298B2
公开(公告)日：2010-04-20
申请号：US11355316
申请日：2006-02-16
申请人： Thomas Wissel
发明人： Thomas Wissel
IPC分类号： G01N33/53 , G01N33/553 , G01N33/544
CPC分类号： G01N33/54333 , G01N33/54326 , G01N33/76 , Y10S435/962 , Y10S436/80 , Y10S436/804 , Y10S436/805
摘要： The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to the person skilled in the art and include immunoassays and immunometric assays.
摘要翻译： 本发明涉及分析方法，其中确定了液体和固相之间标记物质的分配。 测定法包括固相试剂，其可以是颗粒状或整体状，例如涂覆的管。 本领域技术人员本身已知这种类型的测定法，包括免疫测定和免疫测定。
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公开(公告)号：US20070026459A1
公开(公告)日：2007-02-01
申请号：US11355316
申请日：2006-02-16
申请人： Thomas Wissel
发明人： Thomas Wissel
IPC分类号： G01N33/53 , G01N33/551
CPC分类号： G01N33/54333 , G01N33/54326 , G01N33/76 , Y10S435/962 , Y10S436/80 , Y10S436/804 , Y10S436/805
摘要： The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to the person skilled in the art and include immunoassays and immunometric assays.
摘要翻译： 本发明涉及分析方法，其中确定了液体和固相之间标记物质的分配。 测定法包括固相试剂，其可以是颗粒状或整体状，例如涂覆的管。 本领域技术人员本身已知这种类型的测定法，包括免疫测定和免疫测定。
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公开(公告)号：US07029856B1
公开(公告)日：2006-04-18
申请号：US08466881
申请日：1995-06-06
申请人： Thomas Wissel
发明人： Thomas Wissel
IPC分类号： G01N33/53 , G01N33/553 , G01N33/544
CPC分类号： G01N33/54333 , G01N33/54326 , G01N33/76 , Y10S435/962 , Y10S436/80 , Y10S436/804 , Y10S436/805
摘要： The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to the person skilled in the art and include immunoassays and immunometric assays.
摘要翻译： 本发明涉及分析方法，其中确定了液体和固相之间标记物质的分配。 测定法包括固相试剂，其可以是颗粒状或整体状，例如涂覆的管。 本领域技术人员本身已知这种类型的测定法，包括免疫测定和免疫测定。
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公开(公告)号：US06376209B2
公开(公告)日：2002-04-23
申请号：US09078760
申请日：1998-05-15
申请人： Thomas Wissel , Hermann Keuper , Hubert Nettelhoff , Heinz-Georg Kandel , Reiner Muth , Michael Kraus
发明人： Thomas Wissel , Hermann Keuper , Hubert Nettelhoff , Heinz-Georg Kandel , Reiner Muth , Michael Kraus
IPC分类号： C12Q156
CPC分类号： G01N33/86 , C12Q1/56 , G01N2333/96447
摘要： The present invention relates to a process for increasing the FVII sensitivity of a thromboplastin reagent by means of heat treatment.
摘要翻译： 本发明涉及一种通过热处理增加凝血活酶激动剂的FVII敏感性的方法。
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