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    READTHROUGH ACETYLCHOLINESTERASE (ACHE-R) FOR TREATING OR PREVENTING PARKINSON'S DISEASE
    6.
    发明申请
    READTHROUGH ACETYLCHOLINESTERASE (ACHE-R) FOR TREATING OR PREVENTING PARKINSON'S DISEASE 审中-公开
    准备乙酰胆碱酯酶（ACHE-R）治疗或预防帕金森病

    公开(公告)号：US20130164288A1

    公开(公告)日：2013-06-27

    申请号：US13820525

    申请日：2011-09-07

    申请人： Hermona Soreq ,  Ilya Ruderfer ,  Yoseph Shaaltiel

    发明人： Hermona Soreq ,  Ilya Ruderfer ,  Yoseph Shaaltiel

    IPC分类号： C12N9/18 ,  C12N9/96

    CPC分类号： A61K38/465 ,  A61K47/60 ,  C12N9/18 ,  C12Y301/01007

    摘要： A method of treating or preventing Parkinson's disease in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R is devoid of an N-terminal extension. An additional method of treating or preventing Parkinson's disease in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of AChE-R, wherein the AChE-R comprises a modification for increasing bioavailability.

    摘要翻译： 公开了在有需要的受试者中治疗或预防帕金森病的方法。 该方法包括向受试者施用治疗有效量的AChE-R，其中AChE-R缺乏N-末端延伸。 公开了一种在受试者中治疗或预防帕金森病的另外的方法。 该方法包括向受试者施用治疗有效量的AChE-R，其中AChE-R包含用于提高生物利用度的修饰。

    Acetylcholinesterase (ACHE)-derived peptide as an inducer of granulocytopoiesis, uses and methods thereof
    7.
    发明授权
    Acetylcholinesterase (ACHE)-derived peptide as an inducer of granulocytopoiesis, uses and methods thereof 有权
    乙酰胆碱酯酶（ACHE）衍生肽作为粒细胞生成的诱导剂，其用途及方法

    公开(公告)号：US07838493B2

    公开(公告)日：2010-11-23

    申请号：US10589116

    申请日：2005-02-10

    申请人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

    发明人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

    IPC分类号： A61K38/00

    CPC分类号： A61K38/465 ,  C12Y301/01007

    摘要： The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.

    摘要翻译： 本发明描述了AChE-R衍生肽（也称为ARP）作为造血细胞分化和扩增的诱导剂，特别是针对粒细胞群体的用途。 此外，还提出了使用ARP作为血小板生成素和促炎细胞因子的诱导剂。 在造血干细胞的移植前引发中还可以使用ARP。 本文还描述了利用ARP的其他用途和方法。

    Uses of antibodies against AChE and peptides thereof
    8.
    发明授权
    Uses of antibodies against AChE and peptides thereof 有权
    使用抗AChE抗体及其肽

    公开(公告)号：US07063948B1

    公开(公告)日：2006-06-20

    申请号：US09980263

    申请日：2000-05-31

    申请人： Hermona Soreq ,  Daniela Kaufer ,  Alon Friedman ,  Shlomo Seidman

    发明人： Hermona Soreq ,  Daniela Kaufer ,  Alon Friedman ,  Shlomo Seidman

    IPC分类号： G01N17/26 ,  C07K16/00 ,  C07K5/00

    CPC分类号： C07K16/40 ,  G01N2800/2821

    摘要： The invention relates to antibodies recognizing acetylcholinesterase or a C-terminal peptide derived from acetyl-cholinesterase, useful in diagnosing central nervous system (CNS) stress, elevated glucocorticoid level, disruption of the blood-brain barrier or Alzheimer's disease. The invention also relates to methods for the diagnosis of central nervous system (CNS) stress, elevated glucocorticoid level or disruption of the blood-brain barrier in a mammal, by use of the antibodies of the invention.

    摘要翻译： 本发明涉及可用于诊断中枢神经系统（CNS）应激，升高的糖皮质激素水平，血脑屏障或阿尔茨海默氏病破坏的乙酰胆碱酯酶或源自乙酰胆碱酯酶的C-末端肽的抗体。 本发明还涉及通过使用本发明的抗体诊断中枢神经系统（CNS）应激，升高的糖皮质激素水平或哺乳动物血脑屏障破坏的方法。

    Transgenic non-human mammals producing a cholinesterase in their milk
    9.
    发明授权
    Transgenic non-human mammals producing a cholinesterase in their milk 失效
    转基因非人哺乳动物在其牛奶中产生胆碱酯酶

    公开(公告)号：US06987211B1

    公开(公告)日：2006-01-17

    申请号：US09310638

    申请日：1999-05-12

    申请人： Hermona Soreq ,  Haim Zakut ,  Moshe Shani

    发明人： Hermona Soreq ,  Haim Zakut ,  Moshe Shani

    IPC分类号： A01K67/027 ,  C12P21/00

    CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2227/50 ,  A01K2267/03 ,  A01K2267/0356 ,  C12N9/18 ,  C12Q1/46

    摘要： The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been identified in various malignant tumor cells. In a further aspect, the invention relates to a transgenic animal assay system for evaluating efficacy of drugs against cholinergic proteins, prior to or in the course of therapeutic treatment. Transgenic animals, preferably developing tadpole of Xenopus or mice which express human AChE, are used. The transgenic animal assay system is also useful for evaluating the toxicity of substances which potentially block human AChE (e.g. organophosphorous compounds).

    摘要翻译： 本发明涉及人乙酰胆碱酯酶（AChE）的新型替代形式及其编码的核苷酸序列。 已经在各种恶性肿瘤细胞中鉴定了编码人类AChE的新型形式的基因。 在另一方面，本发明涉及用于在治疗治疗之前或治疗过程中评价药物对胆碱能蛋白的功效的转基因动物测定系统。 使用转基因动物，优选发育表达人AChE的非洲爪蟾的t us或小鼠。 转基因动物测定系统也可用于评估可能阻断人类AChE（例如有机磷化合物）的物质的毒性。

    Human cholinesterase genes
    10.
    发明授权
    Human cholinesterase genes 失效
    人胆碱酯酶基因

    公开(公告)号：US5215909A

    公开(公告)日：1993-06-01

    申请号：US572911

    申请日：1990-08-15

    申请人： Hermona Soreq

    发明人： Hermona Soreq

    IPC分类号： C12N9/18

    CPC分类号： C12N9/18

    摘要： This invention is directed to genetically engineered proteins having human ChE activity, and more particularly, the activity of human AChE or human pseudo-ChE. The invention also provides for DNA sequences encoding such proteins, and more specifically DNA sequences comprising the entire coding region for encoding such complete proteins, and DNA expression vectors comprising such sequences. The invention also provides for DNA, which as been joined outside living cells, capable of infecting culturable cells, to be maintained therein and in progenies thereof which is adapted to encode such active proteins. The invention further provides culturable cells infected with recombinant DNA defined above, and to purified proteins having human ChE activity produced by such cells. There are further provided antibodies interacting with human AChE and pseudo-ChE and assays based on the use of such antibodies. The invention also provides compositions counteracting the effects of succinylcholine and of organophosphorus, containing as active ingredient an effective dosage of proteins defined above.

    摘要翻译： 本发明涉及具有人ChE活性的基因工程蛋白质，更具体地说，涉及人AChE或人类伪ChE的活性。 本发明还提供了编码这种蛋白质的DNA序列，更具体地，包括编码这种完整蛋白质的整个编码区的DNA序列，以及包含这些序列的DNA表达载体。 本发明还提供了能够感染可培养细胞的活体细胞外的DNA，其被保持在其中，并且其后代适于编码这种活性蛋白质。 本发明还提供了用上述定义的重组DNA感染的可培养细胞，以及由这些细胞产生的具有人ChE活性的纯化蛋白质。 进一步提供与人AChE和假ChE相互作用的抗体以及基于使用这种抗体的测定。 本发明还提供了抵消琥珀酰胆碱和有机磷的作用的组合物，其含有作为活性成分的有效剂量的上述蛋白质。