公开(公告)号：US09857369B2

公开(公告)日：2018-01-02

申请号：US14338205

申请日：2014-07-22

申请人： HIPEP LABORATORIES ,  NIPPON LIGHT METAL COMPANY, LTD.

发明人： Kiyoshi Nokihara ,  Akiyoshi Hirata ,  Yasuo Oka ,  Yasushi Takebayashi

IPC分类号： G01N33/545 ,  C12Q1/68 ,  G01N33/543 ,  C08J3/28 ,  B01L3/00

CPC分类号： G01N33/545 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01L3/50 ,  C08J3/28 ,  C12Q1/6837 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/273

摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.

公开(公告)号：US12103983B2

公开(公告)日：2024-10-01

申请号：US17299035

申请日：2019-10-31

申请人： HiPep Laboratories

发明人： Kiyoshi Nokihara ,  Yuki Tominaga ,  Atsushi Kitagawa ,  Shun Nokihara

IPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/64

CPC分类号： C07K7/06 ,  C07K7/64 ,  A61K38/00

摘要： Disclosed are a novel compound having a higher angiogenic effect than that of a known peptide-based angiogenic agent, and an angiogenic agent including the novel compound. The compound is represented by the following formula [1]: Cyclic(Cys-O2Oc-SVV(F/Y)GLRG-Cys)-NH2 (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), the following formula [II]: Cyclic(O2Oc-SVV(F/Y)GLRQ)-NH2 [II] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), or the following formula [III]: O2Oc-SVV(F/Y)GLR-NH2 [III] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6).