-
1.发明授权Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors 有权针对HER2的氨基酸序列和包含它们的多肽用于治疗癌症和/或肿瘤公开(公告)号：US08975382B2
公开(公告)日：2015-03-10
申请号：US12744991
申请日：2008-11-27
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译： 本发明涉及针对表皮生长因子受体2（HER2）的氨基酸序列和纳米抗体，以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽 序列。
-
2.发明申请AMINO ACID SEQUENCES DIRECTED AGAINST HER2 AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF CANCERS AND/OR TUMORS 有权指导针对HER2的氨基酸序列和包含癌症和/或肿瘤的治疗的多肽公开(公告)号：US20110059090A1
公开(公告)日：2011-03-10
申请号：US12744991
申请日：2008-11-27
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译： 本发明涉及针对表皮生长因子受体2（HER2）的氨基酸序列和纳米抗体，以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽 序列。
-
公开(公告)号：US08188223B2
公开(公告)日：2012-05-29
申请号：US11587749
申请日：2006-05-17
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/241 , A61K2039/505 , C07K14/525 , C07K16/18 , C07K16/468 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum albumin, which sequences do not significantly reduce or inhibit the binding of serum albumin to FcRn or significantly reduce the half-life of serum albumin. It further relates to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.
摘要翻译： 本发明涉及能够结合血清白蛋白的氨基酸序列，该序列不显着降低或抑制血清白蛋白与FcRn的结合或显着降低血清白蛋白的半衰期。 它还涉及包含或基本上由这样的氨基酸序列组成的蛋白质和多肽; 涉及编码这种氨基酸序列，蛋白质或多肽的核酸; 包括这样的氨基酸序列，蛋白质和多肽的组合物，特别是药物组合物; 以及这些氨基酸序列，蛋白质和多肽的使用。
-
公开(公告)号：US20080267949A1
公开(公告)日：2008-10-30
申请号：US11999497
申请日：2007-12-05
申请人： Hilde Adi Pierrette Revets , Joost Alexander Kolkman , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Hilde Adi Pierrette Revets , Joost Alexander Kolkman , Hendricus Renerus Jacobus Mattheus Hoogenboom
IPC分类号： A61K39/395 , C07K14/435 , C07H21/00 , C12N5/10 , A61K38/16 , C40B30/04 , A61P43/00
CPC分类号： C07K16/18 , C07K16/32 , C07K2317/22 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2319/31 , G01N33/5047 , G01N33/6857
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译： 本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。
-
公开(公告)号：US20070269422A1
公开(公告)日：2007-11-22
申请号：US11517816
申请日：2006-09-08
申请人： Els Beirnaert , Hilde Adi Pierrette Revets , Hendricus Renerus Jacobus Mattheus Hoogenboom , Heidi Maria Florence Jonckheere , Torsten Dreier
发明人： Els Beirnaert , Hilde Adi Pierrette Revets , Hendricus Renerus Jacobus Mattheus Hoogenboom , Heidi Maria Florence Jonckheere , Torsten Dreier
IPC分类号： A61K39/395 , A61K31/7052 , A61K48/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N5/06 , C12P1/04
CPC分类号： C07K16/18 , C07K16/241 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum albumin; to compounds, proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides. Particularly, the amino acid sequences and compounds of the present invention bind to or otherwise associate with serum albumin in such a way that, when the amino acid sequence or compound is bound to or otherwise associated with a serum albumin molecule in a primate, it exhibits a serum half-life of at least 50% of the natural half-life of serum albumin in said primate.
摘要翻译： 本发明涉及能够结合血清白蛋白的氨基酸序列; 包括或基本上由这样的氨基酸序列组成的化合物，蛋白质和多肽; 涉及编码这种氨基酸序列，蛋白质或多肽的核酸; 包括这样的氨基酸序列，蛋白质和多肽的组合物，特别是药物组合物; 以及这些氨基酸序列，蛋白质和多肽的使用。 特别地，本发明的氨基酸序列和化合物与血清白蛋白结合或以其它方式结合，使得当氨基酸序列或化合物与灵长类动物中的血清白蛋白分子结合或以其他方式结合时，其显示出 所述灵长类动物中血清白蛋白的天然半衰期至少为50％的血清半衰期。
-
6.发明申请PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽公开(公告)号：US20120253008A1
公开(公告)日：2012-10-04
申请号：US13495120
申请日：2012-06-13
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译： 本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。
-
7.发明授权Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same 失效能够结合血清蛋白和化合物的肽，构建体和包含其的多肽公开(公告)号：US08217140B2
公开(公告)日：2012-07-10
申请号：US12424986
申请日：2009-04-16
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译： 本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。
-
8.发明申请PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽公开(公告)号：US20110243954A1
公开(公告)日：2011-10-06
申请号：US13018047
申请日：2011-01-31
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K14/765 , A61K2039/505 , C07K16/18 , C07K16/2866 , C07K16/32 , C07K16/36 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： Provided are pharmaceutical compositions, preparations or formulations including a compounds or constructs that include at least one amino acid sequence that is directed against serum albumin and at least one therapeutic moiety. The pharmaceutical compositions, preparations or formulations are preparations or formulations that are suitable for and/or intended for, e.g., pulmonary administration. Methods for use of the pharmaceutical compositions, preparations or formulations also are provided.
摘要翻译： 提供的药物组合物，制剂或制剂包括包含至少一个针对血清白蛋白和至少一个治疗部分的氨基酸序列的化合物或构建体。 药物组合物，制剂或制剂是适合于和/或用于例如肺部给药的制剂或制剂。 还提供了使用药物组合物，制剂或制剂的方法。
-
9.发明申请PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 失效能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽公开(公告)号：US20090281277A1
公开(公告)日：2009-11-12
申请号：US12424986
申请日：2009-04-16
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译： 本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。
-
公开(公告)号：US20110189203A1
公开(公告)日：2011-08-04
申请号：US12745023
申请日：2008-11-27
IPC分类号： A61K39/395 , C07K16/18 , C07K16/24 , C07K16/28 , C07H21/04 , C12P21/06 , C12N5/16 , A61P35/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to protein and polypeptide constructs that comprise single variable domains that are linked to an Fc portion. The immunoglobulin constructs comprise two polypeptide chains in which each polypeptide chain comprises two or more single variable domains that are linked, usually via a suitable hinge region or linker, to one or more constant domains that, together, form an Fc portion. The invention also relates to polypeptide chains that form part of such constructs and/or that can be used to form such constructs. The invention further relates to nucleotide sequences and nucleic acids that encode or can be used to express such constructs or polypeptide chains; to methods for producing such constructs and polypeptides chains; to compositions (and in particular pharmaceutical compositions) that comprise such constructs or polypeptide chains; and to uses of such constructs, polypeptide chains or compositions.
摘要翻译： 本发明涉及包含与Fc部分连接的单个可变结构域的蛋白质和多肽构建体。 免疫球蛋白构建体包含两条多肽链，其中每个多肽链包含两个或更多个单可变结构域，其通常通过合适的铰链区或接头连接到一个或多个恒定区，一起形成Fc部分。 本发明还涉及形成这种构建体的一部分的多肽链和/或可用于形成此类构建体的多肽链。 本发明还涉及编码或可用于表达此类构建体或多肽链的核苷酸序列和核酸; 涉及产生这种构建体和多肽链的方法; 包括这样的构建体或多肽链的组合物（特别是药物组合物）; 以及这种构建体，多肽链或组合物的用途。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.048 秒)
