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公开(公告)号：US08188223B2
公开(公告)日：2012-05-29
申请号：US11587749
申请日：2006-05-17
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/241 , A61K2039/505 , C07K14/525 , C07K16/18 , C07K16/468 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum albumin, which sequences do not significantly reduce or inhibit the binding of serum albumin to FcRn or significantly reduce the half-life of serum albumin. It further relates to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.
摘要翻译： 本发明涉及能够结合血清白蛋白的氨基酸序列，该序列不显着降低或抑制血清白蛋白与FcRn的结合或显着降低血清白蛋白的半衰期。 它还涉及包含或基本上由这样的氨基酸序列组成的蛋白质和多肽; 涉及编码这种氨基酸序列，蛋白质或多肽的核酸; 包括这样的氨基酸序列，蛋白质和多肽的组合物，特别是药物组合物; 以及这些氨基酸序列，蛋白质和多肽的使用。
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公开(公告)号：US20070269422A1
公开(公告)日：2007-11-22
申请号：US11517816
申请日：2006-09-08
申请人： Els Beirnaert , Hilde Adi Pierrette Revets , Hendricus Renerus Jacobus Mattheus Hoogenboom , Heidi Maria Florence Jonckheere , Torsten Dreier
发明人： Els Beirnaert , Hilde Adi Pierrette Revets , Hendricus Renerus Jacobus Mattheus Hoogenboom , Heidi Maria Florence Jonckheere , Torsten Dreier
IPC分类号： A61K39/395 , A61K31/7052 , A61K48/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N5/06 , C12P1/04
CPC分类号： C07K16/18 , C07K16/241 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum albumin; to compounds, proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides. Particularly, the amino acid sequences and compounds of the present invention bind to or otherwise associate with serum albumin in such a way that, when the amino acid sequence or compound is bound to or otherwise associated with a serum albumin molecule in a primate, it exhibits a serum half-life of at least 50% of the natural half-life of serum albumin in said primate.
摘要翻译： 本发明涉及能够结合血清白蛋白的氨基酸序列; 包括或基本上由这样的氨基酸序列组成的化合物，蛋白质和多肽; 涉及编码这种氨基酸序列，蛋白质或多肽的核酸; 包括这样的氨基酸序列，蛋白质和多肽的组合物，特别是药物组合物; 以及这些氨基酸序列，蛋白质和多肽的使用。 特别地，本发明的氨基酸序列和化合物与血清白蛋白结合或以其它方式结合，使得当氨基酸序列或化合物与灵长类动物中的血清白蛋白分子结合或以其他方式结合时，其显示出 所述灵长类动物中血清白蛋白的天然半衰期至少为50％的血清半衰期。
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公开(公告)号：US20090028880A1
公开(公告)日：2009-01-29
申请号：US11587749
申请日：2006-05-17
CPC分类号： C07K16/241 , A61K2039/505 , C07K14/525 , C07K16/18 , C07K16/468 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum albumin, which sequences do not significantly reduce or inhibit the binding of serum albumin to FcRn or significantly reduce the half-life of serum albumin. It further relates to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.
摘要翻译： 本发明涉及能够结合血清白蛋白的氨基酸序列，该序列不显着降低或抑制血清白蛋白与FcRn的结合或显着降低血清白蛋白的半衰期。 它还涉及包含或基本上由这样的氨基酸序列组成的蛋白质和多肽; 涉及编码这种氨基酸序列，蛋白质或多肽的核酸; 包括这样的氨基酸序列，蛋白质和多肽的组合物，特别是药物组合物; 以及这些氨基酸序列，蛋白质和多肽的使用。
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4.发明申请Method for displaying loops from immunoglobulin domains in different contexts 审中-公开在不同上下文中显示来自免疫球蛋白结构域的循环的方法公开(公告)号：US20050214857A1
公开(公告)日：2005-09-29
申请号：US10494829
申请日：2002-12-11
IPC分类号： C07K16/00 , C07K16/28 , C12N15/10 , C12Q1/68 , C40B30/04 , C40B40/02 , G01N33/68 , G01N33/53 , C07K14/705
CPC分类号： C40B30/04 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/565 , C07K2317/567 , C12N15/1037 , C12N15/1044 , C40B40/02
摘要： The present invention is related to an isolated polypeptide micro-scaffold displaying immunoglobulin CDR2 or CDR3 polypeptide sequences, comprising a CDR2 or CDR3 polypeptide sequence interconnecting fragments of the adjacent framework polypeptide sequences, which are arranged to form two anti-parallel β-strands. The present invention is further related to a method to search, select or screen for immunoglobulin CDR2 or CDR3 polypeptide sequences that bind to a given antigen or mixture of antigens, comprising the steps of: Creating a CDR library with the method of claim 13 from the genetic information of an individual or group of individuals; Select a CDR, which binds to said antigen or mixture of antigens.
摘要翻译： 本发明涉及显示免疫球蛋白CDR2或CDR3多肽序列的分离的多肽微型支架，其包含互连相邻框架多肽序列的片段的CDR2或CDR3多肽序列，其被布置成形成两个反平行β-链。 本发明还涉及一种搜索，选择或筛选结合给定抗原或抗原混合物的免疫球蛋白CDR2或CDR3多肽序列的方法，包括以下步骤：用权利要求13的方法从 个人或个人群体的遗传信息; 选择与所述抗原或抗原混合物结合的CDR。
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5.发明申请Single domain antibodies directed against interferron-gamma and uses therefor 审中-公开针对干扰素-γ的单结构域抗体并用于其公开(公告)号：US20060034833A1
公开(公告)日：2006-02-16
申请号：US10534345
申请日：2003-11-07
申请人： Els Beirnaert
发明人： Els Beirnaert
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/249 , C07K2317/22 , C07K2317/565 , C07K2317/622 , C07K2317/626
摘要： The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to interferon gamma. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides. It further relates to protocols for screening for agents that modulate the IFN-gamma receptor, and the agents resulting from said screening.
摘要翻译： 本发明涉及衍生自针对干扰素γ的单结构域重链抗体的多肽。 它还涉及骆驼科VHHs的单结构域抗体。 它还涉及施用所述多肽的方法。 它进一步涉及用于筛选调节IFN-γ受体的试剂和由所述筛选产生的试剂的方案。
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