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公开(公告)号：US20100331335A1
公开(公告)日：2010-12-30
申请号：US12701474
申请日：2010-02-05
申请人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
发明人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
IPC分类号： A61K31/498 , C07D409/04 , C07D409/14 , C07D405/14 , C07D409/12 , C07D471/04 , C07D487/04 , C07D417/14 , A61K31/4196 , A61K31/4709 , A61K31/4725 , A61K31/454 , A61K31/4535 , A61K31/4375 , A61K31/437 , A61K31/422 , A61K31/4245 , A61K31/4155 , A61K31/41 , A61K31/4178 , A61K31/497 , C12Q1/48 , C12N5/071 , A61P25/28 , A61P25/16 , A61P25/00
CPC分类号： C07D409/04 , A61K31/381 , A61K31/401 , A61K31/4196 , A61K31/4245 , A61K31/433 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/519 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
摘要翻译： 本公开提供了具有下式结构的c-Jun N-末端激酶（JNK）抑制剂：其盐或溶剂合物，其中环A，Ca，Cb，Z，R 5，W和Cy在本文中定义 。 本公开进一步提供药物组合物，包括本公开的化合物和制备和使用本公开的化合物和组合物的方法，例如治疗和预防各种疾病，例如阿尔茨海默病。
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公开(公告)号：US09073891B2
公开(公告)日：2015-07-07
申请号：US13617630
申请日：2012-09-14
申请人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
发明人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
IPC分类号： C07D409/04 , A61K31/381 , A61K31/433 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/401 , A61K31/4196 , A61K31/4245 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/519
CPC分类号： C07D409/04 , A61K31/381 , A61K31/401 , A61K31/4196 , A61K31/4245 , A61K31/433 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/519 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
摘要翻译： 本公开提供了具有下式结构的c-Jun N-末端激酶（JNK）抑制剂：其盐或溶剂合物，其中环A，Ca，Cb，Z，R 5，W和Cy在本文中定义 。 本公开进一步提供药物组合物，包括本公开的化合物和制备和使用本公开的化合物和组合物的方法，例如治疗和预防各种疾病，例如阿尔茨海默病。
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公开(公告)号：US08450363B2
公开(公告)日：2013-05-28
申请号：US12701474
申请日：2010-02-05
申请人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
发明人： Hing L. Sham , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
IPC分类号： A61K31/38 , A01N43/06 , C07D333/36
CPC分类号： C07D409/04 , A61K31/381 , A61K31/401 , A61K31/4196 , A61K31/4245 , A61K31/433 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/519 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
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公开(公告)号：US20130072494A1
公开(公告)日：2013-03-21
申请号：US13617630
申请日：2012-09-14
申请人： Hing L. SHAM , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
发明人： Hing L. SHAM , Roy K. Hom , Andrei W. Konradi , Gary D. Probst , Simeon Bowers , Anh Truong , R. Jeffrey Neitz , Jennifer Sealy , Gergely Toth
IPC分类号： A61K31/517 , C07D409/04 , A61K31/4725 , C07D413/04 , A61K31/519 , C07D487/04 , A61K31/4196 , A61K31/4245 , C07D471/04 , A61K31/4985 , A61K31/401 , A61K31/498 , C07D417/14 , C07D417/02 , A61K31/4709
CPC分类号： C07D409/04 , A61K31/381 , A61K31/401 , A61K31/4196 , A61K31/4245 , A61K31/433 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/519 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
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公开(公告)号：US08377974B2
公开(公告)日：2013-02-19
申请号：US13213927
申请日：2011-08-19
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , C07D233/64 , C07D231/12 , C07D207/34
CPC分类号： C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号：US20120178733A1
公开(公告)日：2012-07-12
申请号：US13213927
申请日：2011-08-19
申请人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： A61K31/422 , C07D413/14 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K31/4545 , A61K31/4439 , A61K31/496 , A61K31/506 , C07D417/14 , A61K31/541 , A61K31/553 , A61K31/551 , C07D409/14 , C07D409/12 , A61K31/4192 , C07D417/12 , A61K31/427 , A61K31/4178 , A61K31/4709 , A61P9/00 , A61P9/10 , A01N1/02 , A61P7/02 , C07D413/12
CPC分类号： C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US08153670B2
公开(公告)日：2012-04-10
申请号：US12348879
申请日：2009-01-05
申请人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/4192 , C07D249/04 , C07D233/66 , C07D207/34
CPC分类号： C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US20100234352A1
公开(公告)日：2010-09-16
申请号：US12697135
申请日：2010-01-29
申请人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： A61K31/55 , A61K31/497 , A61K31/513 , A61K31/501 , A61K31/551 , A61K31/4192 , A61K31/4439 , A61K31/444 , A61K31/4178 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/538 , A61K31/4709 , A61P7/02 , A61P9/00
CPC分类号： C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式（I）表示的化合物或其药学上可接受的盐，酯或前药，其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US07696352B2
公开(公告)日：2010-04-13
申请号：US11620615
申请日：2007-01-05
申请人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough , Carroll Anna Crew Scarborough, legal representative
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： C07D409/14 , C07D401/14 , C07D409/12 , A61K31/4436
CPC分类号： C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式（I）表示的化合物或其药学上可接受的盐，酯或前药，其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US07521470B2
公开(公告)日：2009-04-21
申请号：US11158274
申请日：2005-06-20
申请人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/4192 , C07D249/04 , C07D233/66 , C07D207/34
CPC分类号： C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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