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公开(公告)号：US20070148150A1
公开(公告)日：2007-06-28
申请号：US11705900
申请日：2007-02-14
申请人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
发明人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
CPC分类号： C07K14/47 , A61K38/1709 , G01N2500/00 , A61K2300/00
摘要： PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby. Furthermore, the present invention provides a pharmaceutical composition containing an effective amount of at least one member selected from the group consisting of the aforementioned compound and the aforementioned inhibitor.
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公开(公告)号：US20060172360A1
公开(公告)日：2006-08-03
申请号：US10519465
申请日：2003-06-27
申请人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
发明人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
CPC分类号： C07K14/47 , A61K38/1709 , G01N2500/00 , A61K2300/00
摘要： PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby. Furthermore, the present invention provides a pharmaceutical composition containing an effective amount of at least one member selected from the group consisting of the aforementioned compound and the aforementioned inhibitor.
摘要翻译： 在本发明中发现PAK4和JIK两者都结合MKK7并直接磷酸化MKK7。 本发明提供了由JNK3引起的c-Jun磷酸化抑制剂及其抑制方法，以及用于预防和/或治疗由JNK3引起的由c-Jun磷酸化引起的病症的药剂，以及用于预防和/或 所有这些都包括抑制选自以下的一种：PAK4与MKK7的结合，PAK4的MKK7的磷酸化，JIK与MKK7的结合以及通过JIK的MKK7的磷酸化。 此外，本发明提供了鉴定抑制PAK4与MKK7结合的化合物，由PAK4引起的MKK7的磷酸化，JIK与MKK7的结合或由JIK引起的MKK7的磷酸化的化合物的方法，以及化合物 由此获得。 此外，本发明提供含有有效量的选自上述化合物和上述抑制剂中的至少一种的药物组合物。
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公开(公告)号：US07195894B2
公开(公告)日：2007-03-27
申请号：US10519465
申请日：2003-06-27
申请人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
发明人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
IPC分类号： C12N15/09
CPC分类号： C07K14/47 , A61K38/1709 , G01N2500/00 , A61K2300/00
摘要： PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby. Furthermore, the present invention provides a pharmaceutical composition containing an effective amount of at least one member selected from the group consisting of the aforementioned compound and the aforementioned inhibitor.
摘要翻译： 在本发明中发现PAK4和JIK两者都结合MKK7并直接磷酸化MKK7。 本发明提供了由JNK3引起的c-Jun磷酸化抑制剂及其抑制方法，以及用于预防和/或治疗由JNK3引起的由c-Jun磷酸化引起的病症的药剂，以及用于预防和/或 所有这些都包括抑制选自以下的一种：PAK4与MKK7的结合，PAK4的MKK7的磷酸化，JIK与MKK7的结合以及通过JIK的MKK7的磷酸化。 此外，本发明提供了鉴定抑制PAK4与MKK7结合的化合物，由PAK4引起的MKK7的磷酸化，JIK与MKK7的结合或由JIK引起的MKK7的磷酸化的化合物的方法，以及化合物 由此获得。 此外，本发明提供含有有效量的选自上述化合物和上述抑制剂中的至少一种的药物组合物。
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公开(公告)号：US20050130224A1
公开(公告)日：2005-06-16
申请号：US10516133
申请日：2003-06-02
申请人： Seiji Saito , Kazuki Ono , Mitsuhito Wada , Kensaku Imai , Shinya Hosogi , Takashi Shimada
发明人： Seiji Saito , Kazuki Ono , Mitsuhito Wada , Kensaku Imai , Shinya Hosogi , Takashi Shimada
摘要： Objective sequence data (10) which is primary sequence information on an objective protein is entered in an interaction site predicting device by the user. A secondary structure prediction simulation is executed on the objective sequence data (10) entered for secondary structure prediction programs (20a to 20d) that predict a secondary structure of a protein from primary sequence information of the protein. Results of secondary structure prediction (30a to 30d) from the respective secondary structure prediction programs (20a to 20d) are compared (60). Based on the comparison result, frustration of a local portion in the primary sequence information of the objective protein is calculated (70). An interaction site of the objective protein is predicted from the calculated frustration of the local portion (80).
摘要翻译： 作为目标蛋白质的主序列信息的目标序列数据（10）由用户输入到交互站点预测装置。 对从二级结构预测程序（20a到20d）输入的目标序列数据（10）执行二级结构预测模拟，其从蛋白质的一级序列信息预测蛋白质的二级结构。 比较来自各个二级结构预测程序（20a至20d）的二级结构预测（30a至30d）的结果（60）。 基于比较结果，计算目标蛋白的一级序列信息中局部部分的挫败（70）。 目标蛋白质的相互作用位点是从计算出的局部部分的挫折中预测的（80）。
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公开(公告)号：US06330539B1
公开(公告)日：2001-12-11
申请号：US09234472
申请日：1999-01-21
申请人： Kuniharu Takayama , Masahiro Matsuoka , Takeshi Koshiba , Shinya Hosogi , Minoru Sekiguchi , Yoshiharu Maeda , Hirohisa Naito
发明人： Kuniharu Takayama , Masahiro Matsuoka , Takeshi Koshiba , Shinya Hosogi , Minoru Sekiguchi , Yoshiharu Maeda , Hirohisa Naito
IPC分类号： G10L1504
CPC分类号： G10L15/1822 , G10L2015/223
摘要： In the dialog interface apparatus of the present invention, input speech is converted to an input semantic representation by a speech recognition unit, and a dialog management unit outputs an output semantic representation that corresponds to the input semantic representation, based on the input semantic representation obtained by the speech recognition unit. Having received the output semantic representation from the dialog management unit, a speech synthesis unit converts the output semantic representation to output speech identifying a specific dialog target and outputs the output speech. Further, the dialog management unit outputs to an innate operation execution unit an innate operation command that corresponds to the input semantic representation. The innate operation execution unit receives the innate operation command from the dialog management unit and executes an operation corresponding to the innate operation command.
摘要翻译： 在本发明的对话界面装置中，输入语音由语音识别单元转换为输入语义表示，对话管理单元根据所输入的语义表示输出与输入语义表示对应的输出语义表示 由语音识别单元。 在从对话管理单元接收到输出语义表示之后，语音合成单元将输出语义表示转换为识别特定对话目标的输出语音，并输出输出语音。 此外，对话管理单元向先天操作执行单元输出与输入的语义表示相对应的固有操作命令。 天生操作执行单元从对话管理单元接收固有操作命令，并执行与先天操作命令相对应的操作。
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6.发明授权Image measurement method, image measurement apparatus and image measurement program storage medium 失效图像测量方法，图像测量装置和图像测量程序存储介质公开(公告)号：US06574361B1
公开(公告)日：2003-06-03
申请号：US09543027
申请日：2000-04-04
IPC分类号： G06K900
摘要： There is disclosed a technology of measuring three-dimensional geometric information on a plane and position information on a point from an image such as the optical flow pattern and a stereo image. It is to determine an azimuth of a measuring plane and/or a superposing time in which the measuring plane is superposed on a predetermined observation point, using a compound ratio {pinfp0p1pc}, which is determined by four positions pinf, p0, p1, pc of a measuring point, where p0 and p1 denote measuring positions at mutually different two measuring times on an arbitrary measuring point appearing on an image obtained through viewing a predetermined measurement space from a predetermined observation point inside the measurement space, respectively, pinf denotes a position of the measuring point after an infinite time elapses, and pc denotes a position of the measuring point at a superposing time in which a measuring plane including the measuring point is superposed on the observation point in the moving continuous state.
摘要翻译： 公开了一种在平面上测量三维几何信息和从诸如光流图案和立体图像的图像上的点上的位置信息的技术。 使用由pinf，p0，p1，pc四个位置确定的复合比{pinfp0p1pc}来确定测量平面的方位角和/或叠加时间，其中测量平面叠加在预定的观察点上 测量点的位置，其中p0和p1分别表示在通过从测量空间内的预定观察点观察预定测量空间而获得的图像上出现的任意测量点上彼此不同的两个测量时间的测量位置，pinf表示测量点的位置 并且pc表示在包括测量点的测量平面叠加在移动连续状态的观察点上的叠加时间处的测量点的位置。
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公开(公告)号：US6018696A
公开(公告)日：2000-01-25
申请号：US909945
申请日：1997-08-12
CPC分类号： G06N3/0454 , G05D1/027 , G06N3/0445 , G05D1/0255 , G05D1/0272
摘要： The present invention relates to a neural network system for determining a position of a mobile object such as a robot, automobile, etc., which comprises a return information processing unit for generating return information corresponding to a relative position of the mobile object from the origin in a move space according to first sensor signal from the first sensor; a sense information processing unit for generating sense information corresponding to an environment state surrounding the moblie object at the relative position according to a second sensor signal from the second sensor; and an information integrating unit for inferring return information corresponding to sense information output from the sense information processing unit after learning a correlation between the return information and the sense information, and integrating the two items of information.
摘要翻译： 本发明涉及一种用于确定诸如机器人，汽车等的移动物体的位置的神经网络系统，该神经网络系统包括返回信息处理单元，用于产生与来自起点的移动物体的相对位置对应的返回信息 根据来自第一传感器的第一传感器信号在移动空间中; 感测信息处理单元，用于根据来自第二传感器的第二传感器信号在相对位置处产生对应于移动对象的环境状态的感测信息; 以及信息积分单元，用于在学习返回信息和感测信息之间的相关性之后，推断与感测信息处理单元输出的感测信息相对应的返回信息，并且对两个信息项进行积分。
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8.发明授权
公开(公告)号：US5640589A
公开(公告)日：1997-06-17
申请号：US406407
申请日：1995-03-20
申请人： Kuniharu Takayama , Yoshiharu Maeda , Kazuo Misue , Shinya Hosogi , Kozo Sugiyama , Hiroyuki Kano
发明人： Kuniharu Takayama , Yoshiharu Maeda , Kazuo Misue , Shinya Hosogi , Kozo Sugiyama , Hiroyuki Kano
CPC分类号： G06T17/00
摘要： Using a writing implement model defined in the O-XYZ coordinate system a character or graphic form is generated on a writing plane model (O-XY plane) defined in the O-XYZ coordinate system. A control polygon for a character or graphical form to be generated is designed in advance in the O-XYZ coordinate system and a smooth writing motion model is generated using local basis functions that are weighted by the coordinate values of the respective vertices of that control polygon. The position component of the writing motion model represents variations in the position of a representative point of the writing implement model in the O-XYZ coordinate system with respect to time, and the posture component of the writing motion model represents time-variations of its inclination in the O-XYZ coordinate system with respect to the O-XYZ coordinate system. The writing implement model and the writing plane model intersect at a time, thereby forming a character segment. If character segments are generated at regular intervals between the start point and the end point of the writing motion, then the entire image of a character or graphic form will be obtained automatically.
摘要翻译： 使用在O-XYZ坐标系中定义的书写工具模型，在O-XYZ坐标系中定义的书写平面模型（O-XY平面）上生成字符或图形。 在O-XYZ坐标系中预先设计要生成的字符或图形形状的控制多边形，并且使用由该控制多边形的各个顶点的坐标值加权的局部基函数来生成平滑的写入运动模型 。 写入运动模型的位置分量表示O-XYZ坐标系中的书写工具模型的代表点相对于时间的位置的变化，并且书写运动模型的姿态分量表示其倾斜的时间变化 在O-XYZ坐标系中相对于O-XYZ坐标系。 写作工具模型和写作平面模型一次相交，从而形成一个字符段。 如果在写入动作的起点和终点之间以规则的间隔生成字符段，则将自动获得字符或图形的整个图像。
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9.发明授权Data converting device for encoding and editing time series data and method thereof 失效用于编码和编辑时间序列数据的数据转换装置及其方法公开(公告)号：US06359621B1
公开(公告)日：2002-03-19
申请号：US09019301
申请日：1998-02-05
IPC分类号： G06F1500
摘要： A data converting device collects time series movement data by measuring a movement of a living thing, encodes the movement data, and stores the encoded data in a storage device. Next, the data converting device generates new encoded data by reading and editing the encoded data. The data converting device then restores the movement data from the encoded data, and reproduces the movement of a virtual character on a display device based on the restored data.
摘要翻译： 数据转换装置通过测量生物的移动来收集时间序列移动数据，编码移动数据，并将编码的数据存储在存储装置中。 接下来，数据转换装置通过读取和编辑编码数据来生成新的编码数据。 数据转换装置然后从编码数据中恢复运动数据，并且基于恢复的数据再现显示装置上的虚拟角色的移动。
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公开(公告)号：US06000827A
公开(公告)日：1999-12-14
申请号：US783011
申请日：1997-01-14
申请人： Shinya Hosogi , Yoshiharu Maeda
发明人： Shinya Hosogi , Yoshiharu Maeda
CPC分类号： G05B13/027 , G05B17/02
摘要： A system identifying device precisely represents as a mathematical model the features of a system such as a robot manipulator, various industrial plants, etc., and can be operated as hardware by identifying an object system over a neural network, thereby successfully identifying a non-linear system as well as a linear system. Furthermore, an adaptive control device can perform an online learning by using the identifying device to obtain a teaching signal to be used in operating the identifying device in an adaptive control device.
摘要翻译： 系统识别装置精确地表示诸如机器人操纵器，各种工业设备等的系统的特征的数学模型，并且可以通过在神经网络上识别对象系统来作为硬件来操作， 线性系统以及线性系统。 此外，自适应控制装置可以通过使用识别装置来获得用于在自适应控制装置中操作识别装置中使用的教学信号来执行在线学习。
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