Polyurethane containing metal phthalocyanine in the main chain
    1.
    发明授权
    Polyurethane containing metal phthalocyanine in the main chain 失效
    聚氨酯在主链中含有金属酞菁

    公开(公告)号:US5053464A

    公开(公告)日:1991-10-01

    申请号:US570117

    申请日:1990-08-20

    IPC分类号: C08G18/38 D01F6/70

    CPC分类号: D01F6/70 C08G18/3897

    摘要: A polyurethane containing a metal phthalocyanine in the main chain is a novel compound and can be divided into two groups; one of which is a linear polymer and the other of which is a cross-linked polymer. This substance is useful as a redox catalyst due to the peculiar properties of the metal phthalocyanine. The polyurethane can be prepared by reacting a metal phthalocyanine polycarboxylic acid with thionyl chloride to obtain a metal phthalocyanine polycarboxylic acid polychloride; synthesizing a metal phthalocyanine polyhydroxy ester from the metal phthalocyanine polycarboxylic acid polychloride and a diol: HO--R.sup.1 --OH through a dehydrochlorination; and then addition-condensation-polymerizing the resulting metal phthalocyanine polyhydroxy ester, a diol: HO--R.sup.2 --OH and a diisocyanate. The polyurethane containing a metal phthalocyanine in the main chain is dissolved in an organic solvent to obtain a stock solution for spinning and the stock solution is spun according to a wet spinning technique to give a polyurethane fiber comprising the polyurethane containing a metal phthalocyanine in the main chain.

    Pyridine derivative
    8.
    发明授权
    Pyridine derivative 失效
    吡啶衍生物

    公开(公告)号:US5922743A

    公开(公告)日:1999-07-13

    申请号:US849148

    申请日:1997-08-07

    摘要: A pyridine derivative represented by the following formula: ##STR1## where R.sup.1 and R.sup.2 are as defined in the specification, or a salt thereof. These compounds directly or indirectly act on neuronal cells in vivo and are effective in the amelioration and curing of nerve disorders due to neuronal degeneration, such as, for example, traumatic symptoms and maladies, disorders induced by drugs such as alcohol and antineoplastic agents, inflammatory disorders, metabolic disorders observed in diabetes, and disorders due to idiopathic degeneration of peripheral nerves. These compounds are also effective for ameliorating and curing symptoms and maladies due to degeneration of central nerves, for example, Alzheimer's disease and cerebrovascular ischemia, Down's syndrome, Parkinson's disease, Huntington's chorea, diseases secondary to cerebral ischemia, cerebral infarction, intracerebral bleeding, head injuries, amnesia, and spinal neuropathy.

    摘要翻译: PCT No.PCT / JP95 / 02399 Sec。 371日期1997年8月7日 102(e)日期1997年8月7日PCT 1995年11月27日PCT公布。 第WO96 / 16942号公报 日期:1996年6月6日由下式表示的吡啶衍生物:其中R1和R2如说明书中所定义,或其盐。 这些化合物在体内直接或间接作用于神经元细胞,并且由于神经元变性(例如创伤性症状和疾病),药物如酒精和抗肿瘤剂引起的疾病,炎性反应,有助于改善和治疗神经障碍 疾病,糖尿病中观察到的代谢紊乱以及由于周围神经特发性退化引起的疾病。 这些化合物对于改善和治疗由于中枢神经变性引起的症状和疾病也是有效的,例如阿尔茨海默病和脑血管缺血,唐氏综合征,帕金森病,亨廷顿舞蹈病,脑缺血继发性疾病,脑梗死,脑内出血,头部 损伤,遗忘和脊髓神经病变。