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公开(公告)号：US07189415B2
公开(公告)日：2007-03-13
申请号：US10998659
申请日：2004-11-30
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.
摘要翻译： 本发明涉及用于快速崩解的药物组合物，其包含保持在形成凝胶的水溶性聚合物作为固体分散体的微溶性药物，其中其含有包含碱和弱或强酸的盐物质 并且具有吸热标准溶液溶液或溶液热。 由于本发明的药物组合物的快速崩解和制剂中包含的药物的快速溶解可以在消费道中独立地进行，可以获得良好的生物利用度。
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公开(公告)号：US20050095289A1
公开(公告)日：2005-05-05
申请号：US10998659
申请日：2004-11-30
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.
摘要翻译： 本发明涉及用于快速崩解的药物组合物，其包含保持在形成凝胶的水溶性聚合物作为固体分散体的微溶性药物，其中其含有包含碱和弱或强酸的盐物质 并且具有吸热标准溶液溶液或溶液热。 由于本发明的药物组合物的快速崩解和制剂中包含的药物的快速溶解可以在消费道中独立地进行，可以获得良好的生物利用度。
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公开(公告)号：US20070014856A1
公开(公告)日：2007-01-18
申请号：US11522977
申请日：2006-09-19
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.
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公开(公告)号：US06899899B2
公开(公告)日：2005-05-31
申请号：US10190568
申请日：2002-07-09
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.
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5.发明申请公开(公告)号：US20050100598A1
公开(公告)日：2005-05-12
申请号：US10961875
申请日：2004-10-07
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译： 本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。 特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后 正在形成片剂，并且被加湿和干燥。 本发明中的片剂是为了提供在保存的水分中的稳定性，因为无定形糖在制造过程中被加湿干燥后，在不可逆反应中变为结晶状态。 本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。 此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。
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6.发明授权公开(公告)号：US06589554B1
公开(公告)日：2003-07-08
申请号：US09646249
申请日：2000-09-14
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
IPC分类号： A61K920
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译： 本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。 特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后 是形成片剂，并且其被加湿和干燥。本发明的片剂是为了在保存的时候提供对水分的稳定性，因为无定形糖在制造过程中被加湿干燥后在非可逆反应中变为结晶状态 。 本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。 此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。
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公开(公告)号：US06803054B2
公开(公告)日：2004-10-12
申请号：US10453422
申请日：2003-06-02
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
IPC分类号： A61K920
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译： 本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。 特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后 是形成片剂并且被加湿和干燥。本发明的片剂是为了在保存的时候提供对水分的稳定性，因为无定形糖在制造过程中被加湿干燥后在非可逆反应中变为结晶状态 。 本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。 此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。
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公开(公告)号：US08900524B2
公开(公告)日：2014-12-02
申请号：US12934237
申请日：2009-03-17
IPC分类号： G01N33/543 , G01N21/55 , G01N21/65
CPC分类号： G01N21/554 , G01N21/658
摘要： There is provided a novel optical sensor utilizing a surface plasmon resonance technique which is capable of detecting a substance to be detected with high sensitivity independently of a wavelength of irradiated light and is capable of obtaining information, other than a refraction index, on the substance to be detected. At the center of a surface of a metallic film 2 which is formed on a substrate and has no aperture, a circular depression 4 with a diameter of 0.1 to 250 nm is formed and with the depression 4 defined as a center, a plurality of depressions 3 are concentrically formed at intervals of 450 to 530 nm.
摘要翻译： 提供了一种利用表面等离子体共振技术的新型光学传感器，其能够独立于照射光的波长检测高灵敏度的物质，并且能够获得物质以外的折射指数以外的信息 被检测。 在形成在基板上并且没有孔的金属膜2的表面的中心处，形成直径为0.1〜250nm的圆形凹部4，将凹部4定义为中心，形成多个凹部 3以450-530nm的间隔同心地形成。
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公开(公告)号：US08736941B2
公开(公告)日：2014-05-27
申请号：US13045746
申请日：2011-03-11
申请人： Yoshihisa Naijo , Tohru Yashiro , Shigenobu Hirano , Masahiro Yanagisawa , Masahiro Masuzawa , Akishige Murakami , Hiroyuki Takahashi , Koh Fujimura , Yoshinori Okada
发明人： Yoshihisa Naijo , Tohru Yashiro , Shigenobu Hirano , Masahiro Yanagisawa , Masahiro Masuzawa , Akishige Murakami , Hiroyuki Takahashi , Koh Fujimura , Yoshinori Okada
IPC分类号： G02F1/153
CPC分类号： G02F1/153 , G02F1/1523 , G02F1/161 , G02F2202/36
摘要： An electrochromic display apparatus is disclosed that includes a stacked body which includes a display electrode and an electrochromic layer that are stacked on each other; a film which includes through holes, and is disposed on one of the display electrode and the electrochromic layer of the stacked body; and an opposed substrate on which an opposed electrode that faces toward the display electrode is formed.
摘要翻译： 公开了一种电致变色显示装置，其包括层叠体，其包括彼此堆叠的显示电极和电致变色层; 包括通孔的薄膜，并且设置在层叠体的显示电极和电致变色层之一上; 以及形成有朝向显示电极的相对电极的相对基板。
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10.发明申请Planar Lightwave Circuit, Design Method for Wave Propagation Circuit, and Computer Program 有权平面光波电路，波传播电路设计方法和计算机程序公开(公告)号：US20120304143A1
公开(公告)日：2012-11-29
申请号：US13558200
申请日：2012-07-25
申请人： Takashi Saida , Yohei Sakamaki , Toshikazu Hashimoto , Tsutomu Kitoh , Hiroshi Takahashi , Masahiro Yanagisawa , Senichi Suzuki , Yasuhiro Hida , Motohaya Ishii , Munehisa Tamura
发明人： Takashi Saida , Yohei Sakamaki , Toshikazu Hashimoto , Tsutomu Kitoh , Hiroshi Takahashi , Masahiro Yanagisawa , Senichi Suzuki , Yasuhiro Hida , Motohaya Ishii , Munehisa Tamura
IPC分类号： G06F17/50
CPC分类号： G02B6/12011 , G02B6/1228 , G02B6/2804
摘要： A planar lightwave circuit is provided which can be easily fabricated by an existing planar-lightwave-circuit fabrication process, which can lower the propagation loss of signal light and which can convert inputted signal light so as to derive desired signal light. A planar lightwave circuit having a core and a clad which are formed on a substrate, has input optical waveguide(s) (111) which inputs signal light, mode coupling part (112) for coupling a fundamental mode of the inputted signal light to a higher-order mode and/or a radiation mode, or mode re-coupling part (113) for re-coupling the higher-order mode and/or the radiation mode to the fundamental mode, and output optical waveguide(s) (114) which outputs signal light. The mode coupling part or the mode re-coupling part is an optical waveguide which has core width and/or height varied continuously.
摘要翻译： 提供一种平面光波电路，其可以通过现有的平面光波形电路制造工艺容易地制造，这可以降低信号光的传播损耗，并且其可以转换输入的信号光以便导出期望的信号光。 具有形成在基板上的芯和包层的平面光波电路具有输入信号光的输入光波导（111），用于将输入的信号光的基模耦合到模式耦合部（112） 高阶模式和/或辐射模式或用于将高阶模式和/或辐射模式重新耦合到基模的模式再耦合部分（113），以及输出光波导（114） 输出信号灯。 模式耦合部分或模式重新耦合部分是具有连续变化的芯宽度和/或高度的光波导。
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