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1.发明授权公开(公告)号：US08841268B2
公开(公告)日：2014-09-23
申请号：US12991335
申请日：2009-05-07
CPC分类号： C12Q1/6886 , A61K31/7105 , A61K31/711 , C07K14/47 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12Q2600/118 , C12Q2600/154 , C12Q2600/178
摘要： The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.
摘要翻译： 该目的旨在全面分析在癌症中经历表观遗传学沉默的miRNA，以鉴定与癌症相关的miRNA，阐明鉴定的miRNA在癌症中的作用，并开发出一种检测癌症的新方法和一种用于癌症的新型治疗剂，涉及 miRNA。 公开了一种用于检测受试者中癌症的方法，其包括检测位于从受试者收集的生物样品中的微小RNA 34b基因和/或微小RNA 34c基因的启动子区域中的CpG岛中的甲基化CpG。 还公开了一种癌症治疗剂，其包含编码BTG4基因或BTG4的核酸，或包含编码miR-34b基因和/或miR-34c基因或miR-34b和/或miR-34c的核酸 。
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2.发明申请公开(公告)号：US20110130341A1
公开(公告)日：2011-06-02
申请号：US12991335
申请日：2009-05-07
CPC分类号： C12Q1/6886 , A61K31/7105 , A61K31/711 , C07K14/47 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12Q2600/118 , C12Q2600/154 , C12Q2600/178
摘要： The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.
摘要翻译： 该目的旨在全面分析在癌症中经历表观遗传学沉默的miRNA，以鉴定与癌症相关的miRNA，阐明鉴定的miRNA在癌症中的作用，并开发出一种检测癌症的新方法和一种用于癌症的新型治疗剂，涉及 miRNA。 公开了一种用于检测受试者中癌症的方法，其包括检测位于从受试者收集的生物样品中的微小RNA 34b基因和/或微小RNA 34c基因的启动子区域中的CpG岛中的甲基化CpG。 还公开了一种癌症治疗剂，其包含编码BTG4基因或BTG4的核酸，或包含编码miR-34b基因和/或miR-34c基因或miR-34b和/或miR-34c的核酸 。
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3.发明申请Method for Detecting Disease-Related Marker Using Gastric Mucosal Lavage Fluid 审中-公开使用胃粘膜灌洗液检测疾病相关标记物的方法公开(公告)号：US20100068702A1
公开(公告)日：2010-03-18
申请号：US12227300
申请日：2007-05-15
申请人： Yoshiyuki Watanabe , Yoshiyuki Watanabe , Minoru Toyota , Kohzoh Imai , Yasuhisa Shinomura , Fumio Itoh , Takashi Tokino
发明人： Yoshiyuki Watanabe , Yoshiyuki Watanabe , Minoru Toyota , Kohzoh Imai , Yasuhisa Shinomura , Fumio Itoh , Takashi Tokino
CPC分类号： C12Q1/6806
摘要： The invention relates to a sample containing a gastric mucosa lavage fluid collected from a subject who has received a gastric mucus removal treatment and a method for detecting a disease-related marker using the same. By using the sample of the invention, the disease-related marker can be detected conveniently, less invasively, highly sensitively and highly accurately.
摘要翻译： 本发明涉及含有从接受胃粘液清除处理的受试者收集的胃粘膜灌洗液和使用其的疾病相关标记物检测方法的样品。 通过使用本发明的样品，可以方便地，较少侵入性地，高灵敏度和高度准确地检测疾病相关标志物。
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