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    Method and kit for detection of cancer, and therapeutic agent for cancer
    1.
    发明授权
    Method and kit for detection of cancer, and therapeutic agent for cancer 有权
    癌症检测方法和试剂盒，癌症治疗剂

    公开(公告)号：US08841268B2

    公开(公告)日：2014-09-23

    申请号：US12991335

    申请日：2009-05-07

    申请人： Hiromu Suzuki ,  Minoru Toyota ,  Kohzoh Imai ,  Yasuhisa Shinomura ,  Takashi Tokino

    发明人： Hiromu Suzuki ,  Minoru Toyota ,  Kohzoh Imai ,  Yasuhisa Shinomura ,  Takashi Tokino

    IPC分类号： C12N15/11 ,  A61K48/00 ,  C12Q1/68 ,  C07H21/02

    CPC分类号： C12Q1/6886 ,  A61K31/7105 ,  A61K31/711 ,  C07K14/47 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2330/10 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/178

    摘要： The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.

    摘要翻译： 该目的旨在全面分析在癌症中经历表观遗传学沉默的miRNA，以鉴定与癌症相关的miRNA，阐明鉴定的miRNA在癌症中的作用，并开发出一种检测癌症的新方法和一种用于癌症的新型治疗剂，涉及 miRNA。 公开了一种用于检测受试者中癌症的方法，其包括检测位于从受试者收集的生物样品中的微小RNA 34b基因和/或微小RNA 34c基因的启动子区域中的CpG岛中的甲基化CpG。 还公开了一种癌症治疗剂，其包含编码BTG4基因或BTG4的核酸，或包含编码miR-34b基因和/或miR-34c基因或miR-34b和/或miR-34c的核酸 。

    Apoptosis inducer
    4.
    发明授权
    Apoptosis inducer 有权
    细胞凋亡诱导物

    公开(公告)号：US08686127B2

    公开(公告)日：2014-04-01

    申请号：US12937107

    申请日：2009-04-13

    申请人： Masashi Idogawa ,  Yasushi Sasaki ,  Takashi Tokino

    发明人： Masashi Idogawa ,  Yasushi Sasaki ,  Takashi Tokino

    IPC分类号： C07H21/04

    CPC分类号： A61K45/06 ,  C07K14/4747

    摘要： This invention relates to an agent, a composition and a product comprising at least one apoptosis-inducing substance, and at least one substance which inhibits expression and/or activity of an apoptosis-inhibiting substance; a method for inducing apoptosis or for treating a proliferative disease using one or more of them; a nucleic acid construct comprising a nucleic acid molecule encoding a protein to be expressed and a nucleic acid molecule which inhibits expression of an undesired protein; and a method for expressing a desired protein in a cell while inhibiting the expression of an undesired protein.

    摘要翻译： 本发明涉及包含至少一种凋亡诱导物质的试剂，组合物和产品，以及抑制凋亡抑制物质的表达和/或活性的至少一种物质; 诱导凋亡或使用其中一种或多种治疗增殖性疾病的方法; 包含编码待表达蛋白质的核酸分子和抑制不想要的蛋白质表达的核酸分子的核酸构建体; 以及在抑制不需要的蛋白质的表达的同时在细胞中表达所需蛋白质的方法。

    APOPTOSIS INDUCER
    5.
    发明申请
    APOPTOSIS INDUCER 有权
    病毒感染

    公开(公告)号：US20110105589A1

    公开(公告)日：2011-05-05

    申请号：US12937107

    申请日：2009-04-13

    申请人： Masashi Idogawa ,  Yasushi Sasaki ,  Takashi Tokino

    发明人： Masashi Idogawa ,  Yasushi Sasaki ,  Takashi Tokino

    IPC分类号： A61K31/7088 ,  C12N15/63 ,  C07H21/04 ,  C12N5/00 ,  A61P35/00

    CPC分类号： A61K45/06 ,  C07K14/4747

    摘要： This invention relates to an agent, a composition and a product comprising at least one apoptosis-inducing substance, and at least one substance which inhibits expression and/or activity of an apoptosis-inhibiting substance; a method for inducing apoptosis or for treating a proliferative disease using one or more of them; a nucleic acid construct comprising a nucleic acid molecule encoding a protein to be expressed and a nucleic acid molecule which inhibits expression of an undesired protein; and a method for expressing a desired protein in a cell while inhibiting the expression of an undesired protein.

    摘要翻译： 本发明涉及包含至少一种凋亡诱导物质的试剂，组合物和产品，以及抑制凋亡抑制物质的表达和/或活性的至少一种物质; 诱导凋亡或使用其中一种或多种治疗增殖性疾病的方法; 包含编码待表达蛋白质的核酸分子和抑制不想要的蛋白质表达的核酸分子的核酸构建体; 以及在抑制不需要的蛋白质的表达的同时在细胞中表达所需蛋白质的方法。

    Isolated nucleic acid molecule encoding a human skeletal muscle-specific receptor
    6.
    发明授权
    Isolated nucleic acid molecule encoding a human skeletal muscle-specific receptor 失效
    分离的编码人骨骼肌特异性受体的核酸分子

    公开(公告)号：US06255472B1

    公开(公告)日：2001-07-03

    申请号：US09381681

    申请日：2000-01-10

    申请人： Takashi Tokino ,  Yusuke Nakamura

    发明人： Takashi Tokino ,  Yusuke Nakamura

    IPC分类号： C07H2104

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： Novel human genes usable in gene diagnosis and development of new therapeutic methods are disclosed. Specifically, human genes containing a nucleotide sequence encoding the entirety of or a portion of the amino acid sequence represented by SEQ ID NO:3, in particular, ones which are under the specific transcriptional regulation by a tumor suppressor gene p53.

    摘要翻译： 公开了可用于基因诊断和新治疗方法开发的新型人类基因。 具体地说，包含编码SEQ ID NO：3所示的氨基酸序列的全部或一部分的核苷酸序列的人基因，特别是由肿瘤抑制基因p53进行特异转录调控的基因。