公开(公告)号：US08440179B2

公开(公告)日：2013-05-14

申请号：US12525172

申请日：2008-02-29

申请人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

发明人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

IPC分类号： A61K35/74 ,  A23K1/16 ,  A23C19/032 ,  A61P3/04

CPC分类号： A23C19/054 ,  A23C9/1234 ,  A23C9/18 ,  A23K10/18 ,  A23L33/135 ,  A23Y2220/49 ,  A61K35/744 ,  A61K35/747

摘要： Provide a visceral fat reducing agent for reducing the diseases and conditions associated with the metabolic syndrome which represents a condition where various risk factors such as those for hypertension, hyperlipemia, glucose tolerance dysfunction, etc., have accumulated, or simply reducing an accumulation of visceral fat, wherein the effective ingredient of said visceral fat reducing agent includes fungus bodies of lactic bacteria, especially lactic bacteria belonging to the Lactobacillus sp. and Lactococcus sp. and/or cultures thereof, while also providing a beverage, food or feed containing said visceral fat reducing agent.

摘要翻译： 提供一种内脏减脂剂，用于减少与代谢综合征相关的疾病和病症，代谢综合征是各种危险因素如高血压，高脂血症，葡萄糖耐量异常等积累的危险因素，或简单地减少内脏积累 脂肪，其中所述内脏脂肪还原剂的有效成分包括乳酸菌的真菌体，特别是属于乳杆菌属的乳酸菌。 和乳球菌属 和/或其培养物，同时还提供含有所述内脏脂肪还原剂的饮料，食品或饲料。

公开(公告)号：US20100021445A1

公开(公告)日：2010-01-28

申请号：US12525172

申请日：2008-02-29

申请人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

发明人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

IPC分类号： A61K35/74 ,  C12N1/20 ,  A61P3/00 ,  A61P3/04

CPC分类号： A23C19/054 ,  A23C9/1234 ,  A23C9/18 ,  A23K10/18 ,  A23L33/135 ,  A23Y2220/49 ,  A61K35/744 ,  A61K35/747

摘要： Provide a visceral fat reducing agent for reducing the diseases and conditions associated with the metabolic syndrome which represents a condition where various risk factors such as those for hypertension, hyperlipemia, glucose tolerance dysfunction, etc., have accumulated, or simply reducing an accumulation of visceral fat, wherein the effective ingredient of said visceral fat reducing agent includes fungus bodies of lactic bacteria, especially lactic bacteria belonging to the Lactobacillus sp. and Lactococcus sp. and/or cultures thereof, while also providing a beverage, food or feed containing said visceral fat reducing agent.

摘要翻译： 提供一种内脏减脂剂，用于减少与代谢综合征相关的疾病和病症，代谢综合征是各种危险因素如高血压，高脂血症，葡萄糖耐量异常等积累的危险因素，或简单地减少内脏积累 脂肪，其中所述内脏脂肪还原剂的有效成分包括乳酸菌的真菌体，特别是属于乳杆菌属的乳酸菌。 和乳球菌属 和/或其培养物，同时还提供含有所述内脏脂肪还原剂的饮料，食品或饲料。

公开(公告)号：US20130172344A1

公开(公告)日：2013-07-04

申请号：US13528688

申请日：2012-06-20

申请人： Motohide SATOH ,  Hiroshi Kawakami ,  Yoshiharu Itoh ,  Hisashi Shinkai ,  Takahisa Motomura ,  Hisateru Aramaki ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Shuichi Wamaki

发明人： Motohide SATOH ,  Hiroshi Kawakami ,  Yoshiharu Itoh ,  Hisashi Shinkai ,  Takahisa Motomura ,  Hisateru Aramaki ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Shuichi Wamaki

IPC分类号： C07D471/04 ,  C07D215/58 ,  C07D417/06 ,  C07D401/06 ,  C07D215/56 ,  C07D409/06

CPC分类号： A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/5377 ,  A61K45/06 ,  C07D215/56 ,  C07D215/58 ,  C07D401/06 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04

摘要： An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.

摘要翻译： 作为活性成分的含有下式[I]表示的4-氧代喹啉化合物的抗HIV剂，其中各符号如说明书中所述，或其药学上可接受的盐。 本发明的化合物具有HIV整合酶抑制作用，可用作预防或治疗AIDS的抗HIV剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，化合物可以成为更有效的抗HIV剂。 由于该化合物对整合酶具有高的抑制活性，因此可提供对人体副作用较小的安全药剂。

公开(公告)号：US08467718B2

公开(公告)日：2013-06-18

申请号：US13257821

申请日：2010-03-26

申请人： Toshihiro Suzuki ,  Ichiro Okajima ,  Hiroshi Kawakami ,  Manhee Jo ,  Daisuke Ochi ,  Tomohiro Nagata ,  Motonari Kobayashi ,  Yuki Oyabu

发明人： Toshihiro Suzuki ,  Ichiro Okajima ,  Hiroshi Kawakami ,  Manhee Jo ,  Daisuke Ochi ,  Tomohiro Nagata ,  Motonari Kobayashi ,  Yuki Oyabu

IPC分类号： H04H60/66

CPC分类号： H04W60/00 ,  G06Q30/00 ,  H04W24/00 ,  H04W88/08 ,  H04W88/12

摘要： For easily and quickly collecting data regarding macroscopic population distribution, and easily and quickly obtaining the survey results, an RNC includes: a location registration signal receiver that receives location registration signals, and a signal number counting module that counts the number of the location registration signals for each sector, and an information analyzing apparatus includes: a population distribution calculation module that calculates population distribution information based on the number of the location registration signals; and an output module that outputs the population distribution information.

摘要翻译： 为了容易且快速地收集关于宏观人口分布的数据，并且容易且快速地获得调查结果，RNC包括：接收位置登记信号的位置登记信号接收器，以及对位置登记信号的数量进行计数的信号数计数模块 并且信息分析装置包括：人口分布计算模块，其基于所述位置登记信号的数量来计算人口分布信息; 以及输出模块，其输出人口分布信息。

公开(公告)号：US08386452B2

公开(公告)日：2013-02-26

申请号：US13321383

申请日：2010-05-10

申请人： Daisuke Ochi ,  Ichiro Okajima ,  Hiroshi Kawakami ,  Toshihiro Suzuki ,  Manhee Jo ,  Tomohiro Nagata ,  Motonari Kobayashi ,  Yuki Oyabu

发明人： Daisuke Ochi ,  Ichiro Okajima ,  Hiroshi Kawakami ,  Toshihiro Suzuki ,  Manhee Jo ,  Tomohiro Nagata ,  Motonari Kobayashi ,  Yuki Oyabu

IPC分类号： G06F17/30

CPC分类号： G06F17/30477

摘要： A data join system of the present invention includes a table determination unit 11 selecting a record b as a join target if a value of a key item included in a record a acquired by a data write unit from a table A falls within a first predetermined range set based on a value of a key item included in the record b stored in a table B, a data join unit joining the selected record b with the record a to generate a record c, and a data write unit storing the record c into a table C. Thus, the success rate of data join can be improved while the accuracy of join of the record b and the record a to be joined is improved.

摘要翻译： 本发明的数据连接系统包括表格确定单元11，如果包括在由数据写入单元从表A获取的记录a中的关键项的值落在第一预定范围内，则选择记录b作为连接目标 基于存储在表B中的记录b中包括的关键项的值进行设置，将所选择的记录b与记录a连接以生成记录c的数据连接单元，以及将记录c存储到 因此，可以提高数据连接的成功率，同时提高记录b和记录a的连接精度。

公开(公告)号：US08267510B2

公开(公告)日：2012-09-18

申请号：US12560505

申请日：2009-09-16

申请人： Hideki Kaimoto ,  Hiroshi Kawakami ,  Yoshiyuki Tsuzawa

发明人： Hideki Kaimoto ,  Hiroshi Kawakami ,  Yoshiyuki Tsuzawa

IPC分类号： B41J2/01

CPC分类号： B41J3/60 ,  B41J11/0005 ,  B41M5/502 ,  B41M5/504

摘要： A inkjet recording method is provided in which occurrence of curling at the time of double-sided recording is prevented. In the method, an inkjet recording medium is used which includes resin coated paper having a resin layer A of thickness “a” at one side of base paper, and a resin layer B thinner than the thickness “a” by a thickness of 3 μm to 20 μm at the other side of the base paper, and ink receiving layers each of which includes an inorganic pigment and a binder and are provided at both sides of the resin coated paper; and an image is recorded on the ink receiving layer at the resin layer B side of the resin coated paper, and subsequently an image is recorded on the ink receiving layer at the resin layer A side of the resin coated paper.

摘要翻译： 提供一种喷墨记录方法，其中防止在双面记录时发生卷曲。 在该方法中，使用喷墨记录介质，其包括在原纸一侧具有厚度“a”的树脂层A的树脂涂布纸和厚度为3μm的厚度比“a”薄的树脂层B 在原纸的另一侧为20μm，油墨接收层各自包括无机颜料和粘合剂，并且设置在树脂涂布纸的两侧; 并且在树脂涂布纸的树脂层B侧的油墨接收层上记录图像，随后在树脂涂布纸的树脂层A侧的油墨接收层上记录图像。

公开(公告)号：US08232401B2

公开(公告)日：2012-07-31

申请号：US11446128

申请日：2006-06-05

申请人： Motohide Satoh ,  Hiroshi Kawakami ,  Yoshiharu Itoh ,  Hisashi Shinkai ,  Takahisa Motomura ,  Hisateru Aramaki ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Shuichi Wamaki

发明人： Motohide Satoh ,  Hiroshi Kawakami ,  Yoshiharu Itoh ,  Hisashi Shinkai ,  Takahisa Motomura ,  Hisateru Aramaki ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Shuichi Wamaki

IPC分类号： C07D215/38

CPC分类号： A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/5377 ,  A61K45/06 ,  C07D215/56 ,  C07D215/58 ,  C07D401/06 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04

摘要： An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.

摘要翻译： 作为活性成分的含有下式[I]表示的4-氧代喹啉化合物的抗HIV剂，其中各符号如说明书中所述，或其药学上可接受的盐。 本发明的化合物具有HIV整合酶抑制作用，可用作预防或治疗AIDS的抗HIV剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，化合物可以成为更有效的抗HIV剂。 由于该化合物对整合酶具有高的抑制活性，因此可提供对人体副作用较小的安全药剂。

公开(公告)号：US08221967B2

公开(公告)日：2012-07-17

申请号：US12521632

申请日：2007-12-27

申请人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

发明人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

IPC分类号： C12Q1/00

CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N2030/8831

摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

摘要翻译： 测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。 通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列 或感兴趣的肽。

公开(公告)号：US20120135749A1

公开(公告)日：2012-05-31

申请号：US13258157

申请日：2010-03-25

申请人： Tomohiro Nagata ,  Ichiro Okajima ,  Hiroshi Kawakami ,  Manhee Jo ,  Daisuke Ochi ,  Toshihiro Suzuki ,  Motonari Kobayashi ,  Yuki Oyabu

发明人： Tomohiro Nagata ,  Ichiro Okajima ,  Hiroshi Kawakami ,  Manhee Jo ,  Daisuke Ochi ,  Toshihiro Suzuki ,  Motonari Kobayashi ,  Yuki Oyabu

IPC分类号： H04W24/00

CPC分类号： G06Q10/04 ,  G01S5/0205 ,  G06Q10/06 ,  G06Q10/10

摘要： To effectively analyze location information of a large number of users that is obtained easily and to quickly collect data with regard to macroscopic user tendencies. A location information analysis device includes: an input module that is adapted to input point data across a plurality of time points with regard to a plurality of users, the point data including location information indicating a position of a user, time information indicating time at which the location information is obtained, and user identifier information with regard to the user; a haunt area extraction module that extracts an area, as a haunt area where the plurality of users frequently haunt, the area in which the point data is concentrated at or more than a predetermined level, based on a distribution status of the input point data plotted on two dimensional map data; and a storage module that stores the extracted haunt area information.

摘要翻译： 有效地分析大量用户的位置信息，并且能够快速收集关于宏观用户倾向的数据。 位置信息分析装置包括：输入模块，适于相对于多个用户跨多个时间点输入点数据，所述点数据包括指示用户位置的位置信息，指示时间的时间信息， 获得位置信息，以及关于用户的用户标识信息; 基于绘制的输入点数据的分布状况，提取区域作为多个用户经常困扰的区域，点数据集中在或超过预定水平的区域的区域提取模块 二维地图数据; 以及存储模块，存储提取的区域信息。

公开(公告)号：US08183215B2

公开(公告)日：2012-05-22

申请号：US12610896

申请日：2009-11-02

申请人： Hiroshi Kawakami ,  Nobuhiro Hanada ,  Susumu Imai

发明人： Hiroshi Kawakami ,  Nobuhiro Hanada ,  Susumu Imai

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K8/02

CPC分类号： A23K20/195 ,  A23K20/121 ,  A23L33/10 ,  A61K31/7028 ,  A61Q11/00

摘要： It is intended to provide an oral flora-improving agent capable of forming a favorable flora in the oral cavity and a food or a drink for improving the oral flora. An oral flora-improving agent containing as an active ingredient a ganglioside and a food, a drink, or a feed for improving the oral flora containing the ganglioside exhibit an antibacterial effect on harmful bacteria in the oral cavity, which are undesirable from the viewpoint of decay and diseases such as periodontal disease, and a growth-improving effect on useful bacteria to be preserved in the oral cavity. Further, the ganglioside is efficaciously used as an active ingredient in an antibacterial agent or an antibacterial drink, food, or feed, a growth promoter, or a food, a drink, or a feed for promoting growth.

摘要翻译： 旨在提供能够在口腔中形成有利菌群的口腔植物改良剂和用于改善口腔菌群的食品或饮料。 含有作为活性成分的神经节苷脂的口腔内植物改善剂和用于改善含有神经节苷脂的口腔菌群的食品，饮料或饲料，对口腔内的有害细菌表现出抗菌作用，从对 衰老和疾病如牙周病，以及对在口腔中保留的有用细菌的生长改善作用。 此外，神经节苷脂有效地用作抗菌剂或抗菌饮料，食品或饲料，生长促进剂或用于促进生长的食品，饮料或饲料中的活性成分。