公开(公告)号：US07557123B2

公开(公告)日：2009-07-07

申请号：US10478862

申请日：2002-05-27

申请人： Hiroshi Matsui ,  Hideo Kobayashi ,  Satoru Azukizawa ,  Masayasu Kasai ,  Akihisa Yoshimi ,  Hiroaki Shirahase

发明人： Hiroshi Matsui ,  Hideo Kobayashi ,  Satoru Azukizawa ,  Masayasu Kasai ,  Akihisa Yoshimi ,  Hiroaki Shirahase

IPC分类号： A61K31/47 ,  C07D217/02 ,  C07D401/02

CPC分类号： C07D413/12 ,  C07D217/26 ,  C07D417/12

摘要： The novel heterocyclic compound of the present invention is a novel heterocyclic compound having the formula (I) Y: R15—C(R14)═N—O— wherein R1 is H or C1-6 alkyl, R2 is H, —CO—C(R4)═C(R4)—R5 wherein R4 is H or C1-4 alkyl, and R5 is C4-8 alkyl, C2-8 alkenyl and the like, and the like, Y is the following group wherein X is O or S, R7 is the same as R4, R8 is R10—C(R9)═C(R9)— wherein R9 is the same as R4, R10 is C3-6 alkyl and the like, and the like, R14 is the same as R4, and R15 is aryl and the like, Y—(CH2)n-O— is bonded to the 6- or 7-position of the tetrahydroisoquinoline skeleton, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I) of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases or an agent for the prophylaxis or treatment of syndrome X.

摘要翻译： 本发明的新型杂环化合物是具有式（I）Y：R 15 -C（R 14）-NO-的新型杂环化合物，其中R 1为H或C 1-6烷基，R 2为H，-CO-C（R 4 ）-C（R4）-R5，其中R4是H或C1-4烷基，R5是C4-8烷基，C2-8链烯基等，Y是下列基团，其中X是O或S， R 7与R 4相同，R 8是R 10 -C（R 9）-C（R 9） - ，其中R 9与R 4相同，R 10是C 3-6烷基等，R 14与R 4相同， R 15为芳基等，Y-（CH 2）n O-键合于四氢异喹啉骨架的6-位或7-位，n为1〜4的整数，或其药学上可接受的盐。 本发明的化合物（I）可用作降血糖药，降血脂药，胰岛素抵抗改善剂，糖尿病治疗剂，糖尿病并发症治疗剂，葡萄糖耐量改善剂，抗动脉硬化药， 抗肥胖剂，抗炎剂，预防或治疗PPAR介导的疾病的药物或用于预防或治疗综合征X的药剂。

公开(公告)号：US06342494B1

公开(公告)日：2002-01-29

申请号：US09355757

申请日：1999-08-04

申请人： Hiroshi Matsui ,  Masayasu Kasai

发明人： Hiroshi Matsui ,  Masayasu Kasai

IPC分类号： C07D47720

CPC分类号： C07D477/20 ,  A61K31/407 ,  Y02P20/55

摘要： A carbapenem compound of the formula (I) wherein R1 is a group hydrolyzable in the body, R2 is selected from the group consisting of aryl groups optionally substituted by 1-3 alkyl groups having 1-4 carbon atoms, 1-alkanoyloxyalkyl, 1-alkoxycarbonyloxyalkyl, phthalidyl and 5-methyl-2-oxo-1,3-dioxolen-4-ylmethyl, R3 and R4 are lower alkyl groups which may be the same or different or instead form a 4- to 6-membered cyclic amino with the adjacent nitrogen selected from the group consisting of azetidinyl, pyrrolidinyl and piperidinyl or a pharmaceutically acceptable salt thereof The carbapenem compound (I) and a pharmaceutically acceptable salt thereof of the present invention show superior absorption from digestive tract by oral administration, and sufficient antibacterial activity against a wide variety of bacterial species. Thus, they are extremely useful as agents for the prophylaxis and treatment of infectious diseases, particularly bacterial infectious diseases. Said agents for the prophylaxis and treatment of infectious diseases can be used as agents for the prophylaxis and treatment of the diseases caused by bacteria (e.g., suppurative diseases, respiratory infectious diseases, inflammatory diseases of biliary tract, urinary tract infection and the like) in warm-blooded animals inclusive of human (e.g., dog, cat, cow, horse, rat, mouse and the like).

摘要翻译： 式（I）的碳青霉烯化合物，其中R 1是在体内可水解的基团，R 2选自任选被1-3个具有1-4个碳原子的烷基取代的芳基，1-烷酰氧基烷基， 烷氧基羰基氧基烷基，邻苯二甲酰基和5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基甲基，R 3和R 4是可以相同或不同的低级烷基，或者形成4-至6-元环状氨基， 选自氮杂环丁烷基，吡咯烷基和哌啶基的相邻氮或其药学上可接受的盐本发明的碳青霉烯化合物（I）及其药学上可接受的盐通过口服给药对消化道具有优异的吸收性，并且具有足够的抗细菌活性 各种细菌种类。 因此，它们作为用于预防和治疗感染性疾病，特别是细菌感染性疾病的药剂是非常有用的。 所述用于预防和治疗感染性疾病的药剂可用作预防和治疗由细菌引起的疾病（例如，化脓性疾病，呼吸道感染性疾病，胆道炎性疾病，尿路感染等）的药物 包括人类（例如狗，猫，牛，马，老鼠，老鼠等）的温血动物。

公开(公告)号：US06589963B2

公开(公告)日：2003-07-08

申请号：US10148386

申请日：2002-05-31

申请人： Hiroshi Matsui ,  Hideo Kobayashi ,  Satoru Azukizawa ,  Masayasu Kasai ,  Akihisa Yoshimi ,  Hiroaki Shirahase

发明人： Hiroshi Matsui ,  Hideo Kobayashi ,  Satoru Azukizawa ,  Masayasu Kasai ,  Akihisa Yoshimi ,  Hiroaki Shirahase

IPC分类号： C07D40112

CPC分类号： C07D217/22

摘要： A heterocyclic compound of the formula [I] wherein R1 is hydrogen atom or lower alkyl, R2 is hydrogen atom, alkyl optionally having a substituent and the like, R3 is hydrogen atom, lower alkyl and the like, A is a single bond or >N—R5 wherein R5 is hydrogen atom or lower alkyl, B is lower alkylene, and Y is aryl optionally having a substituent and the like, and a pharmaceutically acceptable salt thereof show a hypoglycemic action, a blood hypolipidemic action, an insulin resistance-improving action and a PPAR activating action, and are useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complication, a glucose tolerance improver, an anti-atherosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated disease and an agent for the prophylaxis or treatment of syndrome X.

摘要翻译： 式[I]的杂环化合物，其中R 1为氢原子或低级烷基，R 2为氢原子，任选具有取代基的烷基等，R 3为氢原子，低级烷基等，A为单键或> N-R5其中R5为氢原子或低级烷基，B为低级亚烷基，Y为任选具有取代基的芳基等，其药学上可接受的盐呈低血糖作用，降血脂作用，胰岛素抵抗改善 作用和PPAR活化作用，并且可用作降血糖药，降血脂药，胰岛素抵抗改善剂，糖尿病治疗剂，糖尿病并发症治疗剂，葡萄糖耐量改善剂，抗动脉粥样硬化剂，抗 - - 促肥剂，抗炎剂，预防或治疗PPAR介导的疾病的药剂和用于预防或治疗综合症的药剂。

公开(公告)号：US06872732B2

公开(公告)日：2005-03-29

申请号：US10478863

申请日：2002-05-27

申请人： Hiroshi Matsui ,  Hideo Kobayashi ,  Satoru Azukizawa ,  Masayasu Kasai ,  Akihisa Yoshimi ,  Hiroaki Shirahase

发明人： Hiroshi Matsui ,  Hideo Kobayashi ,  Satoru Azukizawa ,  Masayasu Kasai ,  Akihisa Yoshimi ,  Hiroaki Shirahase

IPC分类号： A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61K31/47 ,  C07D401/12

CPC分类号： C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The novel heterocyclic derivative of the present invention is a novel heterocyclic derivative having the formula (I′) wherein R1 is a hydrogen atom or C1-6 alkyl, R2 is —CO—C(R4)═C(R4)—R5 wherein R4 is a hydrogen atom or C1-4 alkyl, and R5 is C4-8 alkyl, C2-8 alkenyl, aryl or aromatic heterocycle, —CO—C≡C—R6 wherein R6 is C1-8 alkyl and the like, R3 is a hydrogen atom or C1-4 alkyl, X is an oxygen atom or a sulfur atom, R20 is optionally substituted phenyl, and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof. The compound (I′) of the present invention is useful as a hypoglycemic agent, a hypolipidemic agent, an insulin resistance improver, a therapeutic agent of diabetes, a therapeutic agent of diabetic complications, a glucose tolerance improver, an anti-arteriosclerosis agent, an anti-obesity agent, an antiinflammatory agent, an agent for the prophylaxis or treatment of PPAR-mediated diseases and an agent for the prophylaxis or treatment of syndrome X.

摘要翻译： 本发明的新型杂环衍生物是具有式（I'）的新型杂环衍生物，其中R 1是氢原子或C 1-6烷基，R 2是-CO-C（R 4） = C（R 4）-R 5其中R 4是氢原子或C 1-4烷基，R 5是C 4-8烷基，C 2-8烯基，芳基或芳族杂环， CO-C = CR 6其中R 6为C 1-8烷基等，R 3为氢原子或C 1-4烷基，X为氧原子或硫原子，R 20为氢原子， 为任选取代的苯基，n为1〜4的整数，或其药学上可接受的盐。 本发明的化合物（I'）可用作降血糖剂，​​降血脂药，胰岛素抵抗改善剂，糖尿病治疗剂，糖尿病并发症治疗剂，葡萄糖耐量改善剂，抗动脉硬化剂， 抗肥胖剂，抗炎剂，预防或治疗PPAR介导的疾病的药剂和用于预防或治疗症状X的药剂。

公开(公告)号：US08754326B2

公开(公告)日：2014-06-17

申请号：US13093374

申请日：2011-04-25

申请人： Katsuhiro Doi ,  Kenichi Okada ,  Hiroshi Matsui

发明人： Katsuhiro Doi ,  Kenichi Okada ,  Hiroshi Matsui

IPC分类号： H01G9/20 ,  H01M14/00

CPC分类号： H01G9/2077 ,  H01G9/2004 ,  H01G9/2022 ,  H01G9/2027 ,  H01G9/2031 ,  H01G9/2059 ,  H01M14/005 ,  Y02E10/542

摘要： The present invention provides a photoelectric conversion device in which changes in photoelectric conversion efficiency with time can be inhibited. The photoelectric conversion device according to the present invention includes: a pair of electrodes; an electrolytic solution disposed between the pair of electrodes; and a sealing portion that links the pair of electrodes and is provided around the electrolytic solution. At least part of the sealing portion includes at least one inorganic sealing portion constituted by an inorganic material and at least one resin sealing portion constituted by a material including a resin. The inorganic sealing portion and the resin sealing portion are disposed along a direction connecting the pair of electrodes.

摘要翻译： 本发明提供可抑制光电转换效率随时间变化的光电转换装置。 根据本发明的光电转换装置包括：一对电极; 设置在所述一对电极之间的电解液; 以及连接所述一对电极并设置在所述电解液周围的密封部。 密封部的至少一部分包括由无机材料构成的至少一个无机密封部和由包含树脂的材料构成的至少一个树脂密封部。 无机密封部和树脂密封部沿着连接该对电极的方向配置。

公开(公告)号：US08629346B2

公开(公告)日：2014-01-14

申请号：US10529818

申请日：2003-10-03

申请人： Hiroshi Matsui ,  Kenichi Okada ,  Takuya Kawashima ,  Nobuo Tanabe ,  Tetsuya Ezure

发明人： Hiroshi Matsui ,  Kenichi Okada ,  Takuya Kawashima ,  Nobuo Tanabe ,  Tetsuya Ezure

IPC分类号： H01L31/0224 ,  H01G9/20

CPC分类号： H01G9/2068 ,  H01G9/2031 ,  H01L51/445 ,  Y02E10/542 ,  Y02P70/521

摘要： In an electrode substrate 1, the surface of a metal circuit layer 12 is covered and insulated by an insulating layer 14. In a photoelectric conversion element that uses this electrode substrate 1, the metal circuit layer is reliably shielded from an electrolyte solution or the like so that corrosion and leak current thereof is effectively prevented, and the photoelectric conversion efficiency can be improved. The insulating layer 14 is preferably made of a material that contains a glass component, and is particularly preferably formed by printing a paste that contains glass frit. The metal circuit layer 12 is preferably formed using a printing method.

摘要翻译： 在电极基板1中，金属电路层12的表面被绝缘层14覆盖并绝缘。在使用该电极基板1的光电转换元件中，金属电路层可靠地屏蔽电解液等 从而有效地防止其腐蚀和漏电流，并且可以提高光电转换效率。 绝缘层14优选由含有玻璃成分的材料构成，特别优选通过印刷含有玻璃料的糊料形成。 金属电路层12优选使用印刷法形成。

公开(公告)号：US08524452B2

公开(公告)日：2013-09-03

申请号：US10590785

申请日：2005-02-25

申请人： Yasunori Minakawa ,  Michie Saito ,  Hiroshi Matsui

发明人： Yasunori Minakawa ,  Michie Saito ,  Hiroshi Matsui

IPC分类号： G01N33/53 ,  G01N33/531 ,  G01N33/536

CPC分类号： G01N33/52

摘要： Disclosed is an agent for inhibiting decrease in measured values in immunoassays, which may reduce the influences by interfering substances in a test sample so as to promote the accuracy of the immunoassays, as well as an immunoassay and a reagent for immunoassays using the same, with which the decrease in the measured values due to the interfering substances is reduced. The agent for inhibiting decrease in measured values in immunoassays, caused by interfering substances, is an ionic surfactant having a molecular weight of 1000 to 100,000, the agent being a polymer in which a hydrophobic cyclic monomer(s) having an ionic functional group(s) is(are) polymerized.

摘要翻译： 公开了一种用于抑制免疫测定中测量值降低的试剂，其可以减少受试样品中的干扰物质的影响，从而提高免疫测定的准确性，以及免疫测定和使用其的免疫测定试剂， 由于干扰物质导致的测量值的降低减少。 用于抑制由干扰物质引起的免疫测定值的降低的试剂是分子量为1000〜100,000的离子性表面活性剂，该试剂是具有离子官能团的疏水性环状单体（s） ）被聚合。

公开(公告)号：US20120100311A1

公开(公告)日：2012-04-26

申请号：US13381035

申请日：2010-08-30

申请人： Norikazu Ito ,  Shinichiro Inaba ,  Hiroshi Matsui

发明人： Norikazu Ito ,  Shinichiro Inaba ,  Hiroshi Matsui

IPC分类号： C23C16/50

CPC分类号： C23C16/24 ,  C23C16/45565 ,  C23C16/505 ,  H01L31/1804 ,  H01L31/202 ,  Y02E10/547 ,  Y02P70/521

摘要： First and second electrodes are provided in a chamber. The second electrode includes a first part supplying a first gas to a space between the first electrode and the second electrode, a plurality of second parts supplying a second gas to the space, a first supply path of the first gas connected to the first part, and a second supply path of the second gas connected to the second parts. The second supply path includes a main part with a first inlet of the second gas, and a branch part including a plurality of gas flow paths with a second inlet of the second gas. A number of the second parts are connected to each of the gas flow paths. The main part and the branch part are structured so that the second material gas does not flow into the second parts from the first inlet as a straight flow.

摘要翻译： 第一和第二电极设置在腔室中。 第二电极包括向第一电极和第二电极之间的空间提供第一气体的第一部分，向该空间供应第二气体的多个第二部分，连接到第一部分的第一气体的第一供应路径， 以及连接到第二部分的第二气体的第二供应路径。 第二供应路径包括具有第二气体的第一入口的主要部分和包括具有第二气体的第二入口的多个气体流动路径的分支部分。 多个第二部分连接到每个气体流动路径。 主要部分和分支部分被构造成使得第二材料气体不以直流从第一入口流入第二部分。

公开(公告)号：US07825330B2

公开(公告)日：2010-11-02

申请号：US11022672

申请日：2004-12-28

申请人： Kenichi Okada ,  Hiroshi Matsui ,  Nobuo Tanabe

发明人： Kenichi Okada ,  Hiroshi Matsui ,  Nobuo Tanabe

IPC分类号： H01L31/00

CPC分类号： H01M14/005 ,  H01G9/2022 ,  H01G9/2031 ,  H01G9/2059

摘要： A solar cell and photovoltaic power generation apparatus including a transparent electrically conductive film, a semiconductor provided on the transparent electrically conductive film, a conductive film opposing the semiconductor, and an electrolyte solution filled between the semiconductor and the conductive film. Metal ions, such as silver ions, may be dissolved in the electrolyte solution. When light is incident on the cell, the metal ions cause an oxidation-reduction reaction in the electrolyte solution and the cell is charged. When the open-circuit voltage decreases because the amount of incident light drops or light is blocked, the cell discharges to function as a secondary cell.

摘要翻译： 一种太阳能电池和光伏发电装置，包括透明导电膜，设置在透明导电膜上的半导体，与半导体相对的导电膜，以及填充在半导体和导电膜之间的电解质溶液。 诸如银离子的金属离子可以溶解在电解质溶液中。 当光入射到电池上时，金属离子在电解质溶液中引起氧化还原反应，并且电池被充电。 当开路电压降低时，由于入射光的量下降或光线被阻挡，电池放电起二次电池的作用。

公开(公告)号：US07776566B2

公开(公告)日：2010-08-17

申请号：US11682083

申请日：2007-03-05

申请人： Hiroshi Matsui ,  Hisashi Kawasaki ,  Megumi Shimaoka ,  Yasuhiro Takenaka ,  Osamu Kurahashi

发明人： Hiroshi Matsui ,  Hisashi Kawasaki ,  Megumi Shimaoka ,  Yasuhiro Takenaka ,  Osamu Kurahashi

IPC分类号： C12P19/38 ,  C12P19/40 ,  C12N9/00 ,  C12N9/12 ,  C12N1/00 ,  C12N1/20

CPC分类号： C12N9/1077 ,  C12P19/38 ,  C12P19/40 ,  C12R1/19

摘要： A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a gene encoding an enzyme which is inactivated purine nucleoside phosphorylase encoded by deoD, a gene encoding an enzyme which is inactivated succinyl-AMP synthase encoded by purA, a gene encoding an enzyme which is inactivated 6-phosphogluconate dehydrase encoded by edd, a gene encoding an enzyme which is inactivated phosphoglucose isomerase encoded by pgi and like is bred and a purine nucleoside is produced by culturing the microorganism.

摘要翻译： 具有编码酶的基因的微生物，其中通过用大肠杆菌的purF编码的PRPP酰胺转移酶中的一个或两个氨基酸取代反馈抑制而脱敏，该基因是编码由purR编码的嘌呤核苷酸生物合成的灭活性阻遏物的蛋白质 编码由deoD编码的失活的嘌呤核苷磷酸化酶的酶的基因，编码由purA编码的失活的琥珀酰-PAMP合酶的酶的基因，编码由edd编码的6-磷酸葡萄糖酸脱水酶的酶的基因， 编码由pgi等编码的失活的磷酸葡萄糖异构酶的酶，并通过培养微生物产生嘌呤核苷。