公开(公告)号：US08367696B2

公开(公告)日：2013-02-05

申请号：US12524758

申请日：2008-02-08

申请人： Shinya Nagashima ,  Toru Kontani ,  Hiroshi Nagata ,  Yuji Matsushima ,  Hisao Hamaguchi ,  Tadatsura Koshika

发明人： Shinya Nagashima ,  Toru Kontani ,  Hiroshi Nagata ,  Yuji Matsushima ,  Hisao Hamaguchi ,  Tadatsura Koshika

IPC分类号： A61K31/439 ,  C07D221/00 ,  C07D221/02

CPC分类号： C07D453/02 ,  C07D471/18

摘要： [PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.[MEANS For SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

摘要翻译： [问题]提供对毒蕈碱M3受体具有拮抗作用并可用作炎性疾病如慢性阻塞性肺疾病（COPD），哮喘的预防和/或治疗剂的活性成分的化合物 喜欢。 解决问题的手段本发明人研究了对毒蕈碱性M3受体的结合具有拮抗作用的化合物，并且已经发现氮杂桥环化合物或其盐对其具有拮抗作用 结合毒蕈碱M3受体，从而完成本发明。 本发明的氮杂桥环化合物对毒蕈碱性M3受体的结合具有拮抗作用，可用作炎性疾病如慢性阻塞性肺疾病（COPD）的预防和/或治疗剂， ，哮喘等。

公开(公告)号：US08328954B2

公开(公告)日：2012-12-11

申请号：US12745933

申请日：2008-12-25

申请人： Hiroshi Nagata ,  Yoshinori Shingaki

发明人： Hiroshi Nagata ,  Yoshinori Shingaki

IPC分类号： H01F1/04

CPC分类号： H01F41/0273 ,  B22F3/02 ,  B22F2998/10 ,  B22F2999/00 ,  B30B11/027 ,  H01F1/0577 ,  B22F9/08 ,  B22F9/023 ,  B22F2009/044 ,  B22F3/093 ,  B22F3/087 ,  B22F3/1025 ,  B22F2003/023 ,  B22F2003/033

摘要： Crystal fractured surfaces of raw meal powder having more equal crystal orientation relationship in the magnetic field are arranged to be assembled together so that a method of manufacturing a permanent magnet which has an extremely high degree of orientation can be provided. In this invention, raw meal powder (P) is filled into a cavity, the raw meal powder (P) is oriented in the magnetic field while being pressed or urged by pressing means that has a smaller area than the cross-sectional area of the cavity. Semi-finished product thus oriented is compression-molded into a predetermined shape in the magnetic field.

摘要翻译： 布置具有在磁场中具有相同的晶体取向关系的生粉粉末的晶体断面，从而组装在一起，从而可以提供具有极高取向度的永久磁铁的制造方法。 在本发明中，将生粉粉末（P）填充到空腔中，生粉食品粉末（P）在磁场中取向，同时被挤压或推压的面积小于 腔。 如此定向的半成品在磁场中被压缩成预定的形状。

公开(公告)号：US20110189498A1

公开(公告)日：2011-08-04

申请号：US13119993

申请日：2009-10-06

申请人： Hiroshi Nagata ,  Yoshinori Shingaki ,  Youichi Hirose ,  Kyoutoshi Miyagi

发明人： Hiroshi Nagata ,  Yoshinori Shingaki ,  Youichi Hirose ,  Kyoutoshi Miyagi

IPC分类号： C25D1/08 ,  B22D23/04 ,  B22D29/00

CPC分类号： B22D23/04 ,  C21D1/72 ,  C21D6/00 ,  C23C2/04 ,  H01F41/0293 ,  Y10T428/12361

摘要： There is provided an evaporating material of thin plate shape which can be manufactured at a reduced cost and at high productivity, the evaporating material being adapted for use in enhancing the coercive force of neodymium-iron-boron sintered magnet by heat treatment while evaporating Dy in vacuum or in reduced-pressure inert gas atmosphere. The evaporating material of this invention has a core member la made of a fire-resistant metal having a multiplicity of through holes, and is made by melting a rare-earth metal or an alloy thereof so as to get adhered to, and solidified on, the core member. In this case, the above-mentioned adhesion is performed by dipping the core member into a molten bath of the rare-earth metal or an alloy thereof, and pulling it out of the molten bath.

摘要翻译： 提供了一种薄板状的蒸发材料，其可以以低成本和高生产率制造，该蒸发材料适用于通过热处理提高钕铁硼烧结磁体的矫顽力，同时将Dy 真空或在减压惰性气体气氛中。 本发明的蒸发材料具有由具有多个通孔的耐火金属制成的芯部件1a，并且通过熔化稀土金属或其合金制成，以使其粘附并固化， 核心成员。 在这种情况下，通过将芯构件浸入稀土金属或其合金的熔池中并将其从熔浴中拉出来进行上述粘合。

公开(公告)号：US20110052799A1

公开(公告)日：2011-03-03

申请号：US12863338

申请日：2009-02-18

申请人： Hiroshi Nagata ,  Yoshinori Shingaki

发明人： Hiroshi Nagata ,  Yoshinori Shingaki

IPC分类号： B05D5/00

CPC分类号： C23C14/5806 ,  B22F3/24 ,  B22F8/00 ,  B22F9/04 ,  B22F2003/241 ,  B22F2003/248 ,  B22F2998/10 ,  C22C33/0278 ,  C22C2202/02 ,  C23C10/06 ,  C23C14/16 ,  H01F1/0577 ,  H01F41/0293 ,  Y02P10/24 ,  Y02W30/541 ,  B22F3/10

摘要： The method has the steps of: grinding a recovered scrap magnet which is an iron-boron-rare earth-based sintered magnet, thereby obtaining a scrap-derived recovered raw material powder; obtaining a sintered body from the scrap-derived recovered raw material powder by a powder metallurgy method; and processing the sintered body. The processing includes the steps of: heating the sintered body disposed in a processing chamber; evaporating a metal evaporating material containing at least one of Dy and Tb in which the metal evaporating material is disposed in the same or another processing chamber; adhering metal atoms evaporated in the evaporating step to a surface of the sintered body while controlling a supply amount of the evaporated metal atoms; and diffusing the adhered metal atoms into grain boundaries and/or grain boundary phases of the sintered body.

摘要翻译： 该方法具有以下步骤：研磨作为铁 - 硼 - 稀土类烧结磁体的回收废铁，从而获得废料源的回收原料粉末; 通过粉末冶金法从废料回收的原料粉末中获得烧结体; 并加工烧结体。 该处理包括以下步骤：加热设置在处理室中的烧结体; 蒸发含有其中金属蒸发材料设置在相同或另一处理室中的Dy和Tb中的至少一种的金属蒸发材料; 在蒸发的金属原子的供给量的同时控制在蒸发工序中蒸发的金属原子到烧结体的表面; 并将附着的金属原子扩散到烧结体的晶界和/或晶界相。

公开(公告)号：US20100310408A1

公开(公告)日：2010-12-09

申请号：US12745933

申请日：2008-12-25

申请人： Hiroshi Nagata ,  Yoshinori Shingaki

发明人： Hiroshi Nagata ,  Yoshinori Shingaki

IPC分类号： B22F1/00 ,  B22F3/02 ,  B22F3/12

CPC分类号： H01F41/0273 ,  B22F3/02 ,  B22F2998/10 ,  B22F2999/00 ,  B30B11/027 ,  H01F1/0577 ,  B22F9/08 ,  B22F9/023 ,  B22F2009/044 ,  B22F3/093 ,  B22F3/087 ,  B22F3/1025 ,  B22F2003/023 ,  B22F2003/033

摘要： Crystal fractured surfaces of raw meal powder having more equal crystal orientation relationship in the magnetic field are arranged to be assembled together so that a method of manufacturing a permanent magnet which has an extremely high degree of orientation can be provided. In this invention, raw meal powder (P) is filled into a cavity, the raw meal powder (P) is oriented in the magnetic field while being pressed or urged by pressing means that has a smaller area than the cross-sectional area of the cavity. Semi-finished product thus oriented is compression-molded into a predetermined shape in the magnetic field.

摘要翻译： 布置具有在磁场中具有相同的晶体取向关系的生粉粉末的晶体断面，从而组装在一起，从而可以提供具有极高取向度的永久磁铁的制造方法。 在本发明中，将生粉粉末（P）填充到空腔中，生粉食品粉末（P）在磁场中取向，同时被挤压或推压的面积小于 腔。 如此定向的半成品在磁场中被压缩成预定的形状。

公开(公告)号：US07748914B2

公开(公告)日：2010-07-06

申请号：US11712310

申请日：2007-02-27

申请人： Hiroshi Nagata

发明人： Hiroshi Nagata

IPC分类号： G03B13/02 ,  G03B19/12

CPC分类号： G03B19/12

摘要： A single-lens reflex camera has a first image pickup device as a main image pickup device, a second image pickup device for live-view observation, a reflection mirror which switches an optical path between an optical path directed toward the first image pickup device and an optical path directed toward the second image pickup device, and a control section. When the shooting operation is instructed with the second image pickup device driven and a live-view displayed, the control section starts driving the reflection mirror to retract the reflection mirror from the optical path, and stops the second image pickup device and starts driving the first image pickup device while the reflection mirror is driven in a retracting direction.

摘要翻译： 单镜反光相机具有作为主要图像拾取装置的第一图像拾取装置，用于实时观察的第二图像拾取装置，用于切换朝向第一图像拾取装置的光路之间的光路的反射镜和 指向第二图像拾取装置的光路，以及控制部。 当第二图像拾取装置被驱动和实时显示指示拍摄操作时，控制部分开始驱动反射镜以使反射镜从光路缩回，并停止第二图像拾取装置并开始驱动第一 当反射镜沿回缩方向被驱动时，图像拾取装置。

公开(公告)号：US20090281072A1

公开(公告)日：2009-11-12

申请号：US12235189

申请日：2008-09-22

申请人： Shinya Nagashima ,  Hiroshi Nagata ,  Masashiro Iwata ,  Masaki Yokota ,  Hiroyuki Moritomo ,  Eiichi Nakai ,  Sadao Kuromitsu ,  Keiko Ohga ,  Makoto Takeuchi

发明人： Shinya Nagashima ,  Hiroshi Nagata ,  Masashiro Iwata ,  Masaki Yokota ,  Hiroyuki Moritomo ,  Eiichi Nakai ,  Sadao Kuromitsu ,  Keiko Ohga ,  Makoto Takeuchi

IPC分类号： A61K31/5377 ,  A61K31/551 ,  A61K31/397 ,  A61P11/06

CPC分类号： C07D403/12 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D451/04 ,  C07D453/02 ,  C07D471/10 ,  C07D487/08

摘要： A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

摘要翻译： 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物，特别是哮喘，慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基， 可以在5位被提供。

公开(公告)号：US07564647B2

公开(公告)日：2009-07-21

申请号：US11287278

申请日：2005-11-28

申请人： Masaya Suwa ,  Keiji Aruga ,  Yoshiharu Matsuda ,  Keishi Shimizu ,  Hiroshi Nagata

发明人： Masaya Suwa ,  Keiji Aruga ,  Yoshiharu Matsuda ,  Keishi Shimizu ,  Hiroshi Nagata

IPC分类号： G11B33/14

CPC分类号： G11B33/146 ,  G11B5/54

摘要： A magnetic disc apparatus has a ramp holding the magnetic head in a position apart from the magnetic disc and a filter case holding a filter in the state of being bent in such a manner that the filter surrounds the ramp together with the magnetic disc. The filter removes dust in airflow which flows in the magnetic disc apparatus accompanying the rotation of the magnetic disc.

摘要翻译： 磁盘装置具有将磁头保持在与磁盘分离的位置的斜面，以及以使得过滤器与磁盘一起围绕斜坡的方式弯曲的状态下保持过滤器的过滤器壳体。 过滤器除去伴随磁盘旋转的磁盘装置中流动的气流中的灰尘。

公开(公告)号：US20060114346A1

公开(公告)日：2006-06-01

申请号：US11235297

申请日：2005-09-26

申请人： Hiroshi Nagata

发明人： Hiroshi Nagata

IPC分类号： H04N5/222

CPC分类号： H04N1/0035 ,  H04N1/00442 ,  H04N1/2112 ,  H04N1/2158 ,  H04N1/32112 ,  H04N2101/00 ,  H04N2201/0084 ,  H04N2201/3214 ,  H04N2201/3215 ,  H04N2201/3273

摘要： A sensed image and shooting time information corresponding to the sensed image are stored on a memory card. A display unit comprises a plurality of display areas at specific consecutive shooting times and displays the shooting time in the display area. A CPU specifies a display area in which a sensed image corresponding to the shooting time as an image-existing area, and enables the display unit to visibly indicate the image-existing area of the display areas specified as the image-existing area, based on a prescribed condition by a cursor. In this case, when the movement of the display area is instructed, the CPU moves only the image-existing area and indicates the existence of an image, by controlling the movement of the cursor.

摘要翻译： 与感测图像相对应的感测图像和拍摄时间信息被存储在存储卡上。 显示单元包括在特定连续拍摄时间的多个显示区域，并且在显示区域中显示拍摄时间。 CPU将与拍摄时间相对应的感测图像作为图像存在区域指定显示区域，并且使显示单元能够基于图像存在区域指定作为图像存在区域指定的显示区域的图像存在区域 光标指定的条件。 在这种情况下，当指示显示区域的移动时，通过控制光标的移动，CPU仅移动图像存在区域并指示图像的存在。

公开(公告)号：US20050246496A1

公开(公告)日：2005-11-03

申请号：US11104144

申请日：2005-04-11

申请人： Hiroshi Nagata

发明人： Hiroshi Nagata

IPC分类号： G06F12/00 ,  G06F17/30 ,  H04N1/21

CPC分类号： G06F17/30988 ,  H04N1/2112 ,  H04N1/2158 ,  H04N2101/00 ,  H04N2201/0084

摘要： An image displaying device comprises a reproduction list creating unit for creating a group of image data within a prescribed range in which a frame number “1” is included and the frame number increases as a first reproduction list and for creating a group of image data within a prescribed range in which a largest frame number is included and the frame number decreases as a second reproduction list, a display controlling unit for reproducing and displaying image data of a frame to be reproduced registered in the second reproduction list in the case that the frame number is set in a direction along which the frame number decreases below the frame number “1” while image data registered in the first reproduction list is reproduced.

摘要翻译： 图像显示装置包括：再现列表创建单元，用于在包括帧号“1”的规定范围内创建一组图像数据，并且帧号作为第一再现列表增加，并且用于创建一组图像数据 其中包括最大帧号并且帧数减少的规定范围作为第二再现列表;显示控制单元，用于在帧的情况下再现和显示登记在第二再现列表中的要再现的帧的图像数据 在第一再现列表中登记的图像数据被再现的同时，在帧号减少到帧号“1”之下的方向上设置数字。