摘要:
An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.
摘要翻译:提供能够降低链霉素相对于真核细胞的抗生素活性(即毒性)而不牺牲相对于原核细胞的抗生素活性的酶以及相对于真核细胞毒性降低的链球菌素衍生物,同时保持抗生素活性 原核细胞及其制造方法。 通过打开链霉素的内酰胺环,具有根据本发明的SEQ ID NO:2,4,6,8,10,12,14或16的氨基酸序列的蛋白质可以降低链球菌D的抗生素活性,相对于 真核细胞,而不牺牲相对于原核细胞的抗生素活性。
摘要:
An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.
摘要翻译:提供能够降低链霉素相对于真核细胞的抗生素活性(即毒性)而不牺牲相对于原核细胞的抗生素活性的酶以及相对于真核细胞毒性降低的链球菌素衍生物,同时保持抗生素活性 原核细胞及其制造方法。 通过打开链霉素的内酰胺环,具有根据本发明的SEQ ID NO:2,4,6,8,10,12,14或16的氨基酸序列的蛋白质可以降低链球菌D的抗生素活性,相对于 真核细胞,而不牺牲相对于原核细胞的抗生素活性。
摘要:
According to one embodiment, an article sales data processing apparatus includes a list display control unit, a selection unit, an editing acceptance unit, and an update unit. The list display control unit causes a list of articles sold in one transaction to be displayed in the details area. The selection unit accepts selection of an article, of the articles displayed in the details area. The editing acceptance unit causes the display unit to display an editing screen for the sales data of the article selected by the selection unit, and accepts editing of the sales data. When the sales data displayed in the editing screen is edited, the update unit updates the sales data of the article selected by the selection unit, of the sales data of each article stored in the transaction storage unit, to the edited data.
摘要:
Disclosed herein is a playlist creation apparatus including a person specification section, a liking extraction section, a searching section, and a playlist creation section. The person specification section is adapted to specify a person captured in an image based on image data. Also, the liking extraction section is adapted to extract a liking of the person specified by said person specification section. The searching section is adapted to search, based on the liking extracted by said liking extraction section, for sound data of sound conforming to the liking. In addition, the a playlist creation section is adapted to create a playlist which defines a reproduction order of the sound data searched out by said searching section during displaying of the image based on the image data.
摘要:
A device for manufacturing resin molded articles for use in optical elements. Said device is provided with a first molding die which is fixed in place; a second molding die, being movable, which has, on a molding die surface of a cavity, a transfer surface for transferring an optical surface to a melted resin injected into the cavity; a nozzle for injecting a fluid under pressure into the melted resin injected into the cavity, thereby forming a void inside said melted resin; and an ejector pin that is provided in the second molding die, protruding from the molding surface thereof, to release a base material from the molding surface.
摘要:
L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (a) or (b), is increased in a medium, and by collecting L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof from the medium: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2, (b) a protein comprising the amino acid sequence of SEQ ID NO: 2, but wherein one or several amino acid residues are substituted, deleted, inserted or added, increase of which activity in the bacterium improves the ability of the bacterium to produce L-cysteine.
摘要翻译:L-半胱氨酸,L-胱氨酸,其衍生物或其前体或其混合物通过培养属于具有L-半胱氨酸生产能力并已经被修饰的家族肠杆菌科的细菌产生,使得蛋白质的活性被编码 通过tolC基因,例如在以下(a)或(b)中定义的蛋白质在培养基中增加,并且通过将L-半胱氨酸,L-胱氨酸,其衍生物或其前体或其混合物从 培养基:(a)包含SEQ ID NO:2的氨基酸序列的蛋白质,(b)包含SEQ ID NO:2的氨基酸序列的蛋白质,但其中一个或几个氨基酸残基被取代,缺失, 插入或添加,细菌中哪种活性的增加提高了细菌产生L-半胱氨酸的能力。
摘要:
An image retrieval assisting apparatus and method for retrieving a desired image program from a number of image programs, such as broadcast contents in a broadcast-contents-recording/reproducing apparatus or a broadcast receiving set. A classification criterion information storage portion stores classification criterion for classifying broadcast contents into a plurality of categories. A program information acquisition portion acquires program information of the broadcast contents. A program information classification portion classifies the program information into the plurality of categories according to the stored classification criterion. An HDD stores the classified program information, and a display displays categories defined by the stored classification criterion horizontally on a monitor screen in a selectable manner and displays only the program information categorized in a selected category vertically on the monitor screen in a selectable manner.
摘要:
The present invention provides a light sensitive planographic printing plate material which excels in printing durability and tone reproduction property in high resolution printing as in FM screening, and an image formation method employing the light sensitive planographic printing plate material. The light sensitive planographic printing plate material is characterized in that a light sensitive layer containing a light sensitive composition containing an addition polymerizable ethylenic double bond-containing compound, a bisimidazole compound as a photopolymerization initiator, a polymer binder and a photosensitizing dye is provided on a support obtained by subjecting one surface of an aluminum plate to (1) chemically etching treatment in an aqueous alkali solution, (2) electrochemically roughening treatment in an aqueous nitric acid solution, (3) chemically etching treatment in an aqueous alkali solution, (4) electrochemically roughening treatment in an aqueous hydrochloric acid solution, (5) chemically etching treatment in an aqueous alkali solution, and (6) anodizing treatment.
摘要:
A method of protonating a hydrogen molecule includes bringing hydrogen gas into contact with a surface of a solid having a relative dielectric constant of more than 78.
摘要:
Disclosed is a process for manufacturing an aluminum support for a planographic printing plate material, the process comprising the steps of electrolytically surface-roughening an aluminum plate in an electrolytic solution, employing a sinewave alternating current; and anodizing the surface-roughened aluminum plate, the electrolytically surface-roughening step comprising a first stage of electrolytically surface-roughening the aluminum plate in a first electrolytic solution containing hydrochloric acid as a main component at a current density of D1 for t1 at a quantity of electricity of Q1 and a second stage of electrolytically surface-roughening the aluminum plate in a second electrolytic solution containing hydrochloric acid as a main component at a current density of D2 for t2 at a quantity of electricity of Q2.