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公开(公告)号：US07977461B2
公开(公告)日：2011-07-12
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译： 本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。
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公开(公告)号：US08389692B2
公开(公告)日：2013-03-05
申请号：US13095098
申请日：2011-04-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
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公开(公告)号：US20090092612A1
公开(公告)日：2009-04-09
申请号：US11912757
申请日：2006-04-28
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara , Motoyasu Honda
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
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公开(公告)号：US20090041783A1
公开(公告)日：2009-02-12
申请号：US11816233
申请日：2006-01-27
申请人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
发明人： Hiroshi Takayama , Kamon Shirakawa , Shoji Furusako , Yoshitaka Hosaka , Tomokazu Matsusue , Katsuki Naitoh , Yumi Hotta , Tetsushi Kawahara
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C07K14/00 , A61P43/00 , G01N33/566 , C12N15/11 , C12P21/04
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/34 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
摘要翻译： 本发明提供具有以下特征的抗体，其活性片段或其衍生物：a）其特异性结合人血小板膜糖蛋白VI（GPVI）; b）激活血小板和/或在体内诱导血小板减少症的功能低; 和c）它通过与血小板接触至少部分地消耗血小板膜上的GPVI。
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公开(公告)号：US20130011868A1
公开(公告)日：2013-01-10
申请号：US13617409
申请日：2012-09-14
申请人： Yoshitaka Hosaka , Katsuki Naitoh , Motoyasu Honda
发明人： Yoshitaka Hosaka , Katsuki Naitoh , Motoyasu Honda
IPC分类号： G01N33/566
CPC分类号： C07K16/28 , C07K2317/34 , G01N33/86 , G01N2333/70503 , G01N2800/32
摘要： The present invention provides a convenient and highly sensitive method of determining sGPVI present in plasma; this is accomplished by establishing a plurality of mouse hybridomas that produce antibody against GPVI and combining the antibodies produced therefrom. Provided thereby are a novel platelet activation marker, a reagent and method for determining this novel platelet activation marker, and novel applications of this marker in, for example, the diagnosis of diseases associated with platelet activation/vascular endothelial injury.
摘要翻译： 本发明提供了一种方便，高灵敏度的测定血浆中存在的sGPVI的方法; 这通过建立产生针对GPVI的抗体并组合由其产生的抗体的多个小鼠杂交瘤来实现。 由此提供了一种新型的血小板活化标记，用于确定该新型血小板活化标记的试剂和方法，以及该标记在例如与血小板活化/血管内皮损伤相关的疾病的诊断中的新应用。
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公开(公告)号：US08323905B2
公开(公告)日：2012-12-04
申请号：US12225722
申请日：2007-03-20
申请人： Yoshitaka Hosaka , Katsuki Naitoh , Motoyasu Honda
发明人： Yoshitaka Hosaka , Katsuki Naitoh , Motoyasu Honda
IPC分类号： G01N33/53
CPC分类号： C07K16/28 , C07K2317/34 , G01N33/86 , G01N2333/70503 , G01N2800/32
摘要： The present invention provides a convenient and highly sensitive method of determining sGPVI present in plasma; this is accomplished by establishing a plurality of mouse hybridomas that produce antibody against GPVI and combining the antibodies produced therefrom. Provided thereby are a novel platelet activation marker, a reagent and method for determining this novel platelet activation marker, and novel applications of this marker in, for example, the diagnosis of diseases associated with platelet activation/vascular endothelial injury.
摘要翻译： 本发明提供了一种方便，高灵敏度的测定血浆中存在的sGPVI的方法; 这通过建立产生针对GPVI的抗体并组合由其产生的抗体的多个小鼠杂交瘤来实现。 由此提供了一种新型的血小板活化标记，用于确定该新型血小板活化标记的试剂和方法，以及该标记在例如与血小板活化/血管内皮损伤相关的疾病的诊断中的新应用。
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公开(公告)号：US20090311728A1
公开(公告)日：2009-12-17
申请号：US12225722
申请日：2007-03-20
申请人： Yoshitaka Hosaka , Katsuki Naitoh , Motoyasu Honda
发明人： Yoshitaka Hosaka , Katsuki Naitoh , Motoyasu Honda
CPC分类号： C07K16/28 , C07K2317/34 , G01N33/86 , G01N2333/70503 , G01N2800/32
摘要： The present invention provides a convenient and highly sensitive method of determining sGPVI present in plasma; this is accomplished by establishing a plurality of mouse hybridomas that produce antibody against GPVI and combining the antibodies produced therefrom. Provided thereby are a novel platelet activation marker, a reagent and method for determining this novel platelet activation marker, and novel applications of this marker in, for example, the diagnosis of diseases associated with platelet activation/vascular endothelial injury.
摘要翻译： 本发明提供了一种方便，高灵敏度的测定血浆中存在的sGPVI的方法; 这通过建立产生针对GPVI的抗体并组合由其产生的抗体的多个小鼠杂交瘤来实现。 由此提供了一种新型的血小板活化标记，用于确定该新型血小板活化标记的试剂和方法，以及该标记在例如与血小板活化/血管内皮损伤相关的疾病的诊断中的新应用。
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公开(公告)号：US20130217050A1
公开(公告)日：2013-08-22
申请号：US13820894
申请日：2011-09-06
申请人： Katsuki Naitoh , Yoshitaka Hosaka
发明人： Katsuki Naitoh , Yoshitaka Hosaka
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/6896 , G01N2333/4728 , G01N2333/78 , G01N2800/2821
摘要： Provided are an agent for noninvasively and easily diagnosing Alzheimer's disease, a method for diagnosing Alzheimer's disease through the measurement, and a measurement kit therefor. The present invention relates to a reagent for measuring soluble GPVI (sGPVI) in a human body fluid; an agent for specifically diagnosing Alzheimer's disease, said agent comprising a reagent for measuring the activation of platelets or coagulation-fibrinolysis system in said human body fluid; and a method for specifically diagnosing Alzheimer's disease, said method comprising a step for measuring the concentration of sGPVI in a collected human body fluid and a step for measuring the activation of platelets or coagulation-fibrinolysis system in said human body fluid.
摘要翻译： 提供了用于非侵入性且容易地诊断阿尔茨海默氏病的药剂，通过测量诊断阿尔茨海默氏病的方法及其测量试剂盒。 本发明涉及一种用于测量人体液中可溶性GPVI（sGPVI）的试剂; 用于特异性诊断阿尔茨海默病的药剂，所述药剂包含用于测量所述人体液中血小板或凝血 - 纤维蛋白溶解系统活化的试剂; 以及用于特异性诊断阿尔茨海默病的方法，所述方法包括测量所收集的人体液中sGPVI浓度的步骤和测量所述人体液中血小板或凝血 - 纤维蛋白溶解系统活化的步骤。
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