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1.发明申请公开(公告)号：US20150291694A1
公开(公告)日：2015-10-15
申请号：US14567653
申请日：2014-12-11
发明人： Hiroyuki ABURATANI , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahashi , Yasuko Kinoshita
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/30 , C07K16/303 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57438 , G01N33/57488 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
摘要翻译： 公开了一种诊断癌症的方法，包括检测ROBO1蛋白。 另外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法， 披露 此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。 此外，公开了通过检测ROBO1蛋白来监测肝炎进展的方法。
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公开(公告)号：US09644029B2
公开(公告)日：2017-05-09
申请号：US14567653
申请日：2014-12-11
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahashi , Yasuko Kinoshita
IPC分类号： C07K16/28 , C07K16/30 , A61K39/00 , G01N33/574 , G01N33/576
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/30 , C07K16/303 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57438 , G01N33/57488 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
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3.发明申请公开(公告)号：US20170233462A1
公开(公告)日：2017-08-17
申请号：US15288508
申请日：2016-10-07
发明人： Hiroyuki ABURATANI , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
IPC分类号： C07K16/18 , C07K17/00 , G01N33/574 , C07K16/30
CPC分类号： C07K16/18 , C07K16/30 , C07K16/303 , C07K17/00 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/734 , G01N33/57488
摘要： Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell disrupting agent and an anti-cancer agent comprising the same, which can disrupt cells, in particular cancer cells.
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公开(公告)号：US20150132782A1
公开(公告)日：2015-05-14
申请号：US14579474
申请日：2014-12-22
发明人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N33/57488 , G01N33/57492 , G01N2333/4722 , G01N2400/00
摘要： Provided is a method for diagnosing cancer by detecting a novel cancer marker. Cancer can be diagnosed by detecting soluble glypican 3 in a test sample.
摘要翻译： 提供了一种通过检测新型癌症标志物来诊断癌症的方法。 可以通过在测试样品中检测可溶性磷脂酰肌醇蛋白3来诊断癌症。
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公开(公告)号：US09513292B2
公开(公告)日：2016-12-06
申请号：US14579474
申请日：2014-12-22
发明人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N33/57488 , G01N33/57492 , G01N2333/4722 , G01N2400/00
摘要： Provided is a method for diagnosing cancer by detecting a novel cancer marker. Cancer can be diagnosed by detecting soluble glypican 3 in a test sample.
摘要翻译： 提供了一种通过检测新型癌症标志物来诊断癌症的方法。 可以通过在测试样品中检测可溶性磷脂酰肌醇蛋白3来诊断癌症。
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6.发明申请Antibody against secreted N-terminal peptide of GPC3 present in blood or C-terminal peptide of GPC3 审中-公开GPC3血液或C末端肽中存在的GPC3分泌型N-末端肽的抗体公开(公告)号：US20100183595A1
公开(公告)日：2010-07-22
申请号：US12584728
申请日：2009-09-11
申请人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
发明人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/18 , C07K16/30 , C07K16/303 , C07K17/00 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/734 , G01N33/57488
摘要： Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell disrupting agent and an anti-cancer agent comprising the same, which can disrupt cells, in particular cancer cells.
摘要翻译： 公开了一种能够检测测试样品中磷脂酰肌醇蛋白聚糖3（GPC3）分泌形式的分泌形式的GPC3的抗体。 可以确定受试者是否患有癌症，特别是肝癌。 还公开了针对GPC的抗体以及细胞破碎剂和包含该抗体的抗癌剂，其可破坏细胞，特别是癌细胞。
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公开(公告)号：US20090226918A1
公开(公告)日：2009-09-10
申请号：US12384165
申请日：2009-04-01
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoka Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoka Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
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公开(公告)号：US20070037204A1
公开(公告)日：2007-02-15
申请号：US11584793
申请日：2006-10-20
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying Gou , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying Gou , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。
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9.发明申请公开(公告)号：US20060188510A1
公开(公告)日：2006-08-24
申请号：US11414676
申请日：2006-04-28
申请人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
发明人： Hiroyuki Aburatani , Yutaka Midorikawa , Kiyotaka Nakano , Iwao Ohizumi , Yukio Ito , Susumu Tokita
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/18 , C07K16/30 , C07K16/303 , C07K17/00 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/732 , C07K2317/734 , G01N33/57488
摘要： Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell disrupting agent and an anti-cancer agent comprising the same, which can disrupt cells, in particular cancer cells.
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公开(公告)号：US20080153104A1
公开(公告)日：2008-06-26
申请号：US10568471
申请日：2004-08-06
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： G01N33/53 , G01N33/48 , G01N33/566 , C12Q1/02
CPC分类号： C12Q1/6886 , A61K31/711 , A61K38/00 , A61K39/0011 , C07K14/82 , C07K16/30 , C12Q2600/136 , G01N33/57484
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。
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