公开(公告)号：US20070037204A1

公开(公告)日：2007-02-15

申请号：US11584793

申请日：2006-10-20

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying Gou ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying Gou ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。

公开(公告)号：US20080153104A1

公开(公告)日：2008-06-26

申请号：US10568471

申请日：2004-08-06

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： G01N33/53 ,  G01N33/48 ,  G01N33/566 ,  C12Q1/02

CPC分类号： C12Q1/6886 ,  A61K31/711 ,  A61K38/00 ,  A61K39/0011 ,  C07K14/82 ,  C07K16/30 ,  C12Q2600/136 ,  G01N33/57484

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。

公开(公告)号：US20110082284A1

公开(公告)日：2011-04-07

申请号：US12807314

申请日：2010-08-31

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： C07K16/18

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。

公开(公告)号：US20090192108A1

公开(公告)日：2009-07-30

申请号：US12229750

申请日：2008-08-26

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： A61K31/7088 ,  C07K14/00 ,  C07K16/00 ,  C07H21/00 ,  C12N15/74 ,  C12N5/10 ,  G01N33/567 ,  C12Q1/68 ,  A61P35/00

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。

公开(公告)号：US09376475B2

公开(公告)日：2016-06-28

申请号：US12807314

申请日：2010-08-31

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： C07K16/00 ,  C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

公开(公告)号：US07812128B2

公开(公告)日：2010-10-12

申请号：US12229750

申请日：2008-08-26

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoko Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： C07K14/00

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。

公开(公告)号：US20090226918A1

公开(公告)日：2009-09-10

申请号：US12384165

申请日：2009-04-01

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoka Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoka Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： C12Q1/68 ,  C07K14/47 ,  C07K16/18 ,  C12N15/12 ,  C12N15/85 ,  C12N5/10 ,  G01N33/574

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

公开(公告)号：US09434775B2

公开(公告)日：2016-09-06

申请号：US12384165

申请日：2009-04-01

申请人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoka Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

发明人： Hiroyuki Aburatani ,  Yoshitaka Hippo ,  Hirokazu Taniguchi ,  Yong xin Chen ,  Shumpei Ishikawa ,  Shin-ichi Fukumoto ,  Takahiro Shimamura ,  Naoka Kamimura ,  Ying qiu Guo ,  Shogo Yamamoto ,  Yukio Ito ,  Hirotaka Ito ,  Toshihiko Ohtomo

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

公开(公告)号：US07794982B2

公开(公告)日：2010-09-14

申请号：US11721737

申请日：2005-12-15

申请人： Hiroyuki Aburatani ,  Shumpei Ishikawa

发明人： Hiroyuki Aburatani ,  Shumpei Ishikawa

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6827 ,  C12Q2531/119 ,  C12Q2527/101

摘要： This invention relates to a method for searching for a genetic polymorphism for identifying a gene whose expression level is different between alleles and to a method for searching for a phenotype-associated genetic polymorphism. More particularly, the invention relates to a method for effectively identifying a gene whose expression level is different between alleles by utilizing a genetic polymorphism present in intranuclear RNA.

摘要翻译： 本发明涉及一种用于寻找用于鉴定等位基因表达水平不同的基因的遗传多态性与用于搜索表型相关遗传多态性的方法的方法。 更具体地，本发明涉及通过利用存在于核内RNA中的遗传多态性来有效地鉴定等位基因的表达水平不同的基因的方法。

公开(公告)号：US20120328624A1

公开(公告)日：2012-12-27

申请号：US13575861

申请日：2011-01-28

申请人： Kenji Yoshida ,  Hiroyuki Aburatani ,  Shumpei Ishikawa

发明人： Kenji Yoshida ,  Hiroyuki Aburatani ,  Shumpei Ishikawa

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P35/00 ,  G01N33/574

CPC分类号： C07K16/3023 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N33/574 ,  G01N2333/4703

摘要： It is intended to disclose an antibody which binds to DLL3 protein. Preferably, the antibody of the present invention recognizes a region from amino acids 216 to 492 in human DLL3 having the amino acid sequence as set forth in SEQ ID NO: 1. The present invention also provides a pharmaceutical composition, for example, an anticancer agent, comprising the antibody of the present invention as an active ingredient. The present invention further discloses a method for diagnosing cancer using the antibody of the present invention and a diagnostic drug for cancer comprising the antibody of the present invention.

摘要翻译： 旨在公开结合DLL3蛋白的抗体。 优选地，本发明的抗体识别具有SEQ ID NO：1所示的氨基酸序列的人DLL3中的氨基酸216至492的区域。本发明还提供药物组合物，例如抗癌剂 ，其包含本发明的抗体作为活性成分。 本发明还公开了使用本发明的抗体和包含本发明的抗体的癌症诊断药物诊断癌症的方法。