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公开(公告)号：US09376475B2
公开(公告)日：2016-06-28
申请号：US12807314
申请日：2010-08-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
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公开(公告)号：US07812128B2
公开(公告)日：2010-10-12
申请号：US12229750
申请日：2008-08-26
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。
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公开(公告)号：US20110082284A1
公开(公告)日：2011-04-07
申请号：US12807314
申请日：2010-08-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。
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公开(公告)号：US20090192108A1
公开(公告)日：2009-07-30
申请号：US12229750
申请日：2008-08-26
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： A61K31/7088 , C07K14/00 , C07K16/00 , C07H21/00 , C12N15/74 , C12N5/10 , G01N33/567 , C12Q1/68 , A61P35/00
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。
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公开(公告)号：US20080153104A1
公开(公告)日：2008-06-26
申请号：US10568471
申请日：2004-08-06
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： G01N33/53 , G01N33/48 , G01N33/566 , C12Q1/02
CPC分类号： C12Q1/6886 , A61K31/711 , A61K38/00 , A61K39/0011 , C07K14/82 , C07K16/30 , C12Q2600/136 , G01N33/57484
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。
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公开(公告)号：US20090226918A1
公开(公告)日：2009-09-10
申请号：US12384165
申请日：2009-04-01
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoka Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoka Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
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公开(公告)号：US09434775B2
公开(公告)日：2016-09-06
申请号：US12384165
申请日：2009-04-01
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoka Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong xin Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoka Kamimura , Ying qiu Guo , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
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公开(公告)号：US20070037204A1
公开(公告)日：2007-02-15
申请号：US11584793
申请日：2006-10-20
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying Gou , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Hirokazu Taniguchi , Yong Chen , Shumpei Ishikawa , Shin-ichi Fukumoto , Takahiro Shimamura , Naoko Kamimura , Ying Gou , Shogo Yamamoto , Yukio Ito , Hirotaka Ito , Toshihiko Ohtomo
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.
摘要翻译： 公开了由具有由SEQ ID NO：1至65中任一个表示的核苷酸序列或其片段的基因编码的蛋白质，识别该蛋白质或其抗原结合片段的抗体，以及具有至少12个 由SEQ ID NO：1至65中任一个表示的核苷酸序列的连续核苷酸或与其互补的核苷酸序列。 本发明的基因和蛋白质可用于诊断和治疗癌症。
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公开(公告)号：US08940488B2
公开(公告)日：2015-01-27
申请号：US11547534
申请日：2005-03-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahshi , Yasuko Kinoshita
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahshi , Yasuko Kinoshita
IPC分类号： G01N33/53 , G01N33/574 , G01N33/576
CPC分类号： G01N33/57438 , C07K2317/732 , C07K2317/734 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
摘要翻译： 公开了一种诊断癌症的方法，包括检测ROBO1蛋白。 另外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法， 披露 此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。 此外，公开了通过检测ROBO1蛋白来监测肝炎进展的方法。
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10.发明申请公开(公告)号：US20070212359A1
公开(公告)日：2007-09-13
申请号：US11547534
申请日：2005-03-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30
CPC分类号： G01N33/57438 , C07K2317/732 , C07K2317/734 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
摘要翻译： 公开了一种诊断癌症的方法，包括检测ROBO1蛋白。 另外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法， 披露 此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。 此外，公开了通过检测ROBO1蛋白来监测肝炎进展的方法。
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