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公开(公告)号：US11219601B2
公开(公告)日：2022-01-11
申请号：US16975161
申请日：2019-02-19
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Shinya Matsumura , Toshihiro Nakanishi , Yasuhisa Kose
Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
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公开(公告)号：US10369115B2
公开(公告)日：2019-08-06
申请号：US14913455
申请日：2014-08-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Keiichiro Tsurushima , Yasuhisa Kose , Shinji Yamasoto , Seiichiro Tsuru , Takaaki Yoshinaga
Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.
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公开(公告)号：US20150231255A1
公开(公告)日：2015-08-20
申请号：US14408423
申请日：2013-06-18
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Takaaki Yoshinaga , Masahiro Sato , Akira Oishi , Yasuhisa Kose
IPC: A61K47/30 , A61K31/196 , A61K47/10 , A61K9/70
CPC classification number: A61K47/30 , A61K9/7053 , A61K9/7069 , A61K31/196 , A61K47/06 , A61K47/10 , A61K47/34 , A61K47/46
Abstract: A transdermal absorption promoting agent for promoting percutaneous absorption of diclofenac sodium, comprising 1-menthyl glyceryl ether, a petroleum-based resin and/or a terpene-based resin, as well as a patch comprising it.
Abstract translation: 一种用于促进双氯芬酸钠的经皮吸收的透皮吸收促进剂，其包含1-薄荷基甘油醚，石油基树脂和/或萜烯系树脂，以及包含它的贴剂。
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Patent Agency Ranking
公开(公告)号：US20140322300A1
公开(公告)日：2014-10-30
申请号：US14363559
申请日：2012-12-06
Applicant: Hisamitsu Pharmaceutical Co., Inc.
Inventor： Masaru Kijima , Yasuhisa Kose , Takaaki Yoshinaga
IPC: A61K31/196 , A61K47/10 , A61K47/02 , A61K9/70
CPC classification number: A61K9/7061 , A61K9/7069 , A61K31/196 , A61K47/02 , A61K47/10
Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer contains diclofenac or a pharmaceutically acceptable salt thereof, glycerin, butylene glycol, and poly(ethylene glycol)monooleate, and a mass ratio between the butylene glycol and the poly(ethylene glycol)monooleate (mass of butylene glycol:mass of poly(ethylene glycol)monooleate) is 1:1 to 4:1.
Abstract translation: 一种贴剂，包括支持层和粘合剂层，其中所述粘合剂层包含双氯芬酸或其药学上可接受的盐，甘油，丁二醇和聚（乙二醇）单油酸酯，并且所述丁二醇和聚 （乙二醇）单油酸酯（丁二醇的质量：聚（乙二醇）单油酸酯的质量）为1:1至4:1。
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公开(公告)号：US11660268B2
公开(公告)日：2023-05-30
申请号：US17536295
申请日：2021-11-29
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Shinya Matsumura , Toshihiro Nakanishi , Yasuhisa Kose
CPC classification number: A61K9/06 , A61K9/107 , A61K31/196 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/44
Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
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公开(公告)号：US11246830B2
公开(公告)日：2022-02-15
申请号：US16975161
申请日：2019-02-19
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Shinya Matsumura , Toshihiro Nakanishi , Yasuhisa Kose
Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
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公开(公告)号：US10292941B2
公开(公告)日：2019-05-21
申请号：US15547645
申请日：2016-02-05
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Kentaro Nakashima , Masahiro Sato , Yasuhisa Kose , Takaaki Yoshinaga
IPC: A61K9/70 , B32B5/02 , A61F13/00 , A61F13/02 , A61K47/06 , A61K47/34 , B32B27/00 , A61K31/045 , A61K31/618
Abstract: Disclosed is an adhesive patch having a support and an adhesive agent layer laminated on the support, wherein the support consists of spunlace nonwoven fabric, the adhesive agent layer comprises an SIS block copolymer and liquid paraffin, the adhesive patch has a first direction, which is a predetermined reference axis direction, and a second direction, which is orthogonal to the first direction, and a bending resistance in the first direction of the adhesive patch is 18 to 30 mm.
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公开(公告)号：US10123977B2
公开(公告)日：2018-11-13
申请号：US14974288
申请日：2015-12-18
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor： Keiichiro Tsurushima , Yasuhisa Kose , Takaaki Yoshinaga
IPC: A61K47/14 , A61K9/70 , A61K31/618 , A61K47/26
Abstract: A gel patch includes a base fabric, an adhesive layer, and a release liner in this order, wherein the adhesive layer contains a physiologically active substance, a water-soluble (meth)acrylic polymer, water, a surfactant, and poly(methyl acrylate/2-ethylhexyl acrylate), and the surfactant comprises a polyethylene glycol fatty acid ester or a polyoxyethylene sorbitan fatty acid ester.
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