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    Diphenyl ether compound, process for producing the same, and use
    1.
    发明申请
    Diphenyl ether compound, process for producing the same, and use 审中-公开
    二苯醚化合物，其制备方法和用途

    公开(公告)号：US20100267778A1

    公开(公告)日：2010-10-21

    申请号：US10567363

    申请日：2004-08-03

    申请人： Shinya Kusuda ,  Yoshisuke Nakayama ,  Masaki Ima ,  Hisao Tajima ,  Sachiko Kato

    发明人： Shinya Kusuda ,  Yoshisuke Nakayama ,  Masaki Ima ,  Hisao Tajima ,  Sachiko Kato

    IPC分类号： A61K31/455 ,  C07C65/28 ,  A61K31/192 ,  A61P3/06 ,  A61K31/235 ,  C07C69/94 ,  C07C59/68 ,  C07D263/32 ,  A61K31/421 ,  C07D277/30 ,  A61K31/426 ,  C07D213/55 ,  A61K31/435 ,  C07C217/90 ,  A61K31/196

    CPC分类号： C07D263/32 ,  C07C65/24 ,  C07C217/90 ,  C07D213/30

    摘要： The present invention relates to a compound represented by formula (I): wherein ring A, ring B and ring D each independently represents a cyclic group which may have a substituent(s); W is a spacer having 1 to 8 atom(s) in its main chain; X is a spacer having 1 to 2 atom(s) in its main chain; Y is a binding bond or a spacer having 1 to 8 atom(s) in its main chain; and Z is an acidic group, or a salt thereof, a solvate thereof or a prodrug thereof. The compound represented by formula (I) has a PPAR δ agonistic action and is useful as a preventive and/or treating agent for diseases where sugar and lipid metabolisms are abnormal (diabetes, hyperlipemia, arteriosclerosis, cardiovascular diseases, obesity and metabolic syndrome or the like), hypertension, circulatory diseases and skin inflammation diseases.

    摘要翻译： 本发明涉及由式（I）表示的化合物：其中环A，环B和环D各自独立地表示可以具有取代基的环状基团。 W是其主链中具有1至8个原子的间隔基; X是其主链中具有1至2个原子的间隔基; Y是其主链中具有1至8个原子的结合键或间隔基; 并且Z是酸性基团，或其盐，其溶剂合物或其前药。 由式（I）表示的化合物具有PPARδ激动作用，并且可用作糖和脂质代谢异常（糖尿病，高脂血症，动脉硬化，心血管疾病，肥胖症和代谢综合征或疾病）的疾病的预防和/或治疗剂 喜欢），高血压，循环系统疾病和皮肤炎症疾病。

    LAMINATED MATERIAL FOR METAL KEY-SHEET, METAL KEY-SHEET, AND METAL KEYPAD
    2.
    发明申请
    LAMINATED MATERIAL FOR METAL KEY-SHEET, METAL KEY-SHEET, AND METAL KEYPAD 审中-公开
    金属钥匙片，金属钥匙片和金属钥匙扣层压材料

    公开(公告)号：US20100009121A1

    公开(公告)日：2010-01-14

    申请号：US12300680

    申请日：2007-05-14

    申请人： Takeshi Kume ,  Koji Miyazaki ,  Hisao Tajima

    发明人： Takeshi Kume ,  Koji Miyazaki ,  Hisao Tajima

    IPC分类号： B32B15/08 ,  B32B15/095 ,  B32B3/10

    CPC分类号： H01H13/704 ,  H01H2221/004 ,  Y10T428/24339 ,  Y10T428/31605 ,  Y10T428/31678

    摘要： The present invention provides a laminated material for metal key-sheet to be used for input button portion of information terminal devices, the laminated material for metal key-sheet including: at least a transparent resin sheet and a metal plate, wherein cut-out letters and so on are formed in the laminated material by etching. The present invention also provides a metal key-sheet in which cut-out letters with a lot of flexibility of design can be formed, and a metal keypad which can be produced by simple methods.

    摘要翻译： 本发明提供一种用于信息终端装置的输入按钮部分的金属按键片层压材料，金属键板用叠层材料至少包括透明树脂片和金属板，其中切割字母 通过蚀刻形成在层压材料中。 本发明还提供了一种金属键盘，其中可以形成具有大量设计灵活性的切割字母，以及可以通过简单的方法制造的金属键盘。

    Image display unit
    3.
    发明申请
    Image display unit 审中-公开
    图像显示单元

    公开(公告)号：US20060132386A1

    公开(公告)日：2006-06-22

    申请号：US11282718

    申请日：2005-11-21

    申请人： Hisao Tajima

    发明人： Hisao Tajima

    IPC分类号： G09G3/20

    CPC分类号： G06F1/1601

    摘要： An image display unit includes an image display section and a support structure. The support structure has a higher part and a lower part, wherein the higher part and the lower part individually have circuits, and the circuit having the maximum height is arranged on the lower part.

    摘要翻译： 图像显示单元包括图像显示部分和支撑结构。 支撑结构具有较高部分和较低部分，其中较高部分和下部分别具有电路，并且具有最大高度的电路布置在下部。

    Image display unit
    5.
    发明授权
    Image display unit 有权

    公开(公告)号：US06989817B2

    公开(公告)日：2006-01-24

    申请号：US10287496

    申请日：2002-11-05

    申请人： Hisao Tajima

    发明人： Hisao Tajima

    IPC分类号： G09G5/00

    CPC分类号： G06F1/1601

    摘要： An image display unit includes an image display section and a support structure. The support structure has a higher part and a lower part, wherein the higher part and the lower part individually have circuits, and the circuit having the maximum height is arranged on the lower part.

    Carboxylic acid derivatives and drugs containing the same as the active ingredient
    6.
    发明授权
    Carboxylic acid derivatives and drugs containing the same as the active ingredient 失效
    羧酸衍生物和含有与活性成分相同的药物

    公开(公告)号：US06506757B1

    公开(公告)日：2003-01-14

    申请号：US09623913

    申请日：2000-09-11

    申请人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    发明人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    IPC分类号： C07D21330

    CPC分类号： C07D213/30 ,  A61K31/00 ,  C07C59/66 ,  C07C59/68 ,  C07C59/72 ,  C07C323/52 ,  C07D213/65 ,  C07D263/32 ,  C07D263/34 ,  C07D263/48 ,  C07D277/24 ,  C07D317/54 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

    摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.

    摘要翻译： 含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。 由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，​​降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施 等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物 疾病或综合征X.

    Carboxylic acid derivatives compounds and agents comprising the compounds as active ingredient
    9.
    发明授权
    Carboxylic acid derivatives compounds and agents comprising the compounds as active ingredient 失效
    羧酸衍生物化合物和包含该化合物作为活性成分的试剂

    公开(公告)号：US07323456B2

    公开(公告)日：2008-01-29

    申请号：US10495158

    申请日：2002-11-11

    申请人： Hisao Tajima ,  Yoshisuke Nakayama

    发明人： Hisao Tajima ,  Yoshisuke Nakayama

    IPC分类号： A61K31/55 ,  C07D413/10 ,  C07D417/10

    CPC分类号： C07D417/10 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/55 ,  C07D263/32 ,  C07D263/48 ,  C07D277/24 ,  C07D277/26 ,  C07D277/42

    摘要： A compound of formula (I) (wherein all symbols are as defined in the specification) and a salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or treatment agent for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

    摘要翻译： 式（I）化合物（其中所有符号如说明书中所定义）及其盐，以及其包含作为活性成分的过氧化物酶体增殖物激活受体调节剂。 由于式（I）化合物具有调节过氧化物酶体增殖物激活受体调节剂的活性，式（I）化合物可用作降血糖剂，​​降血脂剂，与代谢紊乱相关的疾病的预防和/或治疗剂（ 糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，缺血性心脏病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低 药物和缓解糖尿病或综合征X危险因素的药物。

    Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
    10.
    发明授权
    Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
    羧酸衍生物和含有该衍生物作为活性成分的药物组合物

    公开(公告)号：US07211591B2

    公开(公告)日：2007-05-01

    申请号：US11178639

    申请日：2005-07-12

    申请人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    发明人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    IPC分类号： C07D413/12 ,  C07D417/02 ,  A61K31/4427

    CPC分类号： C07D213/30 ,  A61K31/00 ,  C07C59/66 ,  C07C59/68 ,  C07C59/72 ,  C07C323/52 ,  C07D213/65 ,  C07D263/32 ,  C07D263/34 ,  C07D263/48 ,  C07D277/24 ,  C07D317/54 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

    摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.

    摘要翻译： 含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。 由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，​​降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施 等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物 疾病或综合征X.