公开(公告)号：US08314411B2

公开(公告)日：2012-11-20

申请号：US12738705

申请日：2009-04-24

申请人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

发明人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

IPC分类号： A61N5/10 ,  H01J37/256

CPC分类号： A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.

摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。

公开(公告)号：US20110218429A1

公开(公告)日：2011-09-08

申请号：US12738705

申请日：2009-04-24

申请人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

发明人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

IPC分类号： G03B42/02 ,  H01J3/26

CPC分类号： A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject ; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.

摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。

公开(公告)号：US08658991B2

公开(公告)日：2014-02-25

申请号：US13003688

申请日：2009-06-03

申请人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

发明人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

IPC分类号： A61N5/00

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N2005/1087

摘要： In order to obtain a particle beam irradiation apparatus that enlarges the dose distribution of beam spots while suppressing a decrease of the maximum available range of a charged particle beam, the particle beam irradiation apparatus includes a particle beam acceleration means; particle beam transport means; scanning apparatus that includes first scanning means and second scanning means, and two-dimensionally scans the beam; and irradiation control means that controls the scanning apparatus so as to irradiate the beam onto a target region including a plurality of small regions. The irradiation control means controls the first scanning means so as to scan the beam over a small region serving as an irradiation subject among the plurality of the small regions, and controls the second scanning means so as to change the small region serving as the irradiation subject to be a different small region among the plurality of the small regions.

摘要翻译： 为了获得粒子束照射装置，其粒子束照射装置包括粒子束加速装置，粒子束照射装置在抑制带电粒子束的最大可用范围的减小的同时，扩大束斑的剂量分布， 粒子束传送装置; 扫描装置，其包括第一扫描装置和第二扫描装置，并二维地扫描光束; 以及照射控制装置，其控制扫描装置以将束照射到包括多个小区域的目标区域上。 照射控制装置控制第一扫描装置，以便在多个小区域中的用作照射对象的小区域上扫描光束，并且控制第二扫描装置以改变用作照射对象的小区域 成为多个小区域中的不同小区域。

公开(公告)号：US20110108737A1

公开(公告)日：2011-05-12

申请号：US13003688

申请日：2009-06-03

申请人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

发明人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

IPC分类号： H01J37/147

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N2005/1087

摘要： In order to obtain a particle beam irradiation apparatus that enlarges the dose distribution of beam spots while suppressing a decrease of the maximum available range of a charged particle beam, the particle beam irradiation apparatus includes a particle beam acceleration means; particle beam transport means; scanning apparatus that includes first scanning means and second scanning means, and two-dimensionally scans the beam; and irradiation control means that controls the scanning apparatus so as to irradiate the beam onto a target region including a plurality of small regions. The irradiation control means controls the first scanning means so as to scan the beam over a small region serving as an irradiation subject among the plurality of the small regions, and controls the second scanning means so as to change the small region serving as the irradiation subject to be a different small region among the plurality of the small regions.

摘要翻译： 为了获得粒子束照射装置，其粒子束照射装置包括粒子束加速装置，粒子束照射装置在抑制带电粒子束的最大可用范围的减小的同时，扩大束斑的剂量分布， 粒子束传送装置; 扫描装置，其包括第一扫描装置和第二扫描装置，并二维地扫描光束; 以及照射控制装置，其控制扫描装置以将束照射到包括多个小区域的目标区域上。 照射控制装置控制第一扫描装置，以便在多个小区域中的用作照射对象的小区域上扫描光束，并且控制第二扫描装置以改变用作照射对象的小区域 成为多个小区域中的不同小区域。

公开(公告)号：US07054801B2

公开(公告)日：2006-05-30

申请号：US09904889

申请日：2001-07-16

申请人： Hidenobu Sakamoto ,  Yuehu Pu

发明人： Hidenobu Sakamoto ,  Yuehu Pu

IPC分类号： G06F17/50 ,  G06G7/62 ,  A61N5/00 ,  G21G5/00

CPC分类号： A61N5/103 ,  A61N2005/1087

摘要： A radiation exposure region to be irradiated with particle beams and a peripheral region thereof are respectively divided into pluralities of exposure regions, radiation treatment simulation for applying particle beams according to the shape of each divided exposure region is performed, and a radiation treatment condition is obtained for causing the flatness of the radiation exposure region to be in a desired range, and a dose of particle beams applied to the unit exposure region of the peripheral region to be minimum. Thus, the problem of low efficiency of radiation is solved.

摘要翻译： 将用粒子束照射的放射线照射区域及其周边区域分别分割为多个曝光区域，进行根据各分割曝光区域的形状施加粒子束的放射线处理模拟，得到放射线处理条件 用于使辐射曝光区域的平坦度处于期望的范围内，并且将施加到周围区域的单元曝光区域的粒子束的剂量最小化。 因此解决了辐射效率低的问题。

公开(公告)号：US4965520A

公开(公告)日：1990-10-23

申请号：US284419

申请日：1988-12-14

申请人： Hidenobu Sakamoto

发明人： Hidenobu Sakamoto

IPC分类号： G01R33/54

CPC分类号： G01R33/4828

摘要： In an NMR imaging method, the phase encode amount applied to the respective echo signals in the same sequence of operation are made to have different values and the phase encoding magnetic fields Gen are made to disorder the phases of the NMR signals so as not to generate stimulated echo signals. In another aspect, the time periods of application of the signal reading magnetic field Gp applied between the 90.degree. RF pulse and the 180.degree. RF pulse are made to have different values equal in number to the chemical shifts. By varying the time period of application of the signal reading magnetic field, spin echo signals having different phase variance amounts due to the different chemical shifts are generated before or after the time point at which the spin echo due to the RF pulse is expected to occur. Accordingly, control difficulties for synchronizing the RF pulse and the slicing magnetic field and shifting them by the same time length is avoided wherein two chemical shifts can be separated.

摘要翻译： 在NMR成像方法中，以相同的操作顺序施加到各个回波信号的相位编码量使得具有不同的值，并且使相位编码磁场Gen成为使NMR信号的相位紊乱从而不产生 刺激的回波信号。 另一方面，在90°RF脉冲和180°RF脉冲之间施加信号读取磁场Gp的时间周期被制成具有与化学位移相等数量的不同值。 通过改变施加信号读取磁场的时间周期，在由于RF脉冲引起的自旋回波预期发生的时间点之前或之后产生由于不同的化学位移而具有不同相位变化量的自旋回波信号 。 因此，避免了使RF脉冲和切片磁场同步并将其移位相同时间长度的控制困难，其中两个化学位移可以分离。

公开(公告)号：US5263074A

公开(公告)日：1993-11-16

申请号：US869506

申请日：1992-04-16

申请人： Hidenobu Sakamoto

发明人： Hidenobu Sakamoto

IPC分类号： H01J31/50 ,  A61B6/00 ,  G01T1/164 ,  H05G1/60 ,  H05G1/64

CPC分类号： H05G1/60

摘要： In accordance with the distortion correction method for an X-ray radiograph diagnosis device, the distortion center of the X-ray image is determined by use of a plate-shaped object having a circular marker M and a marker center M.sub.0. On the basis of the positions of the sample points M.sub.1 through M.sub.4 upon the circular marker M, the distortion center is inferred. Further, a grid marker pattern is used to determine the magnitudes of pincushion distortion at respective distances from the distortion center. The correction coefficients for correcting the spool distortion at respective distances from the distortion center are determined on the basis of the relationship between the physical and displayed distances from the marker center M.sub.0 to the sample points.

摘要翻译： 根据X射线摄影诊断装置的畸变校正方法，通过使用具有圆形标记M和标记中心M0的板状物体来确定X射线图像的畸变中心。 基于圆形标记M上的采样点M1至M4的位置，推断变形中心。 此外，使用网格标记图案来确定在与失真中心相距的距离处的枕形失真的幅度。 基于从标记中心M0到采样点的物理距离和显示距离之间的关系来确定用于校正来自失真中心的各距离的线轴失真的校正系数。

公开(公告)号：US4857849A

公开(公告)日：1989-08-15

申请号：US172885

申请日：1988-03-25

申请人： Hidenobu Sakamoto

发明人： Hidenobu Sakamoto

IPC分类号： G01R33/341

CPC分类号： G01R33/3678

摘要： The high frequency magnetic field generating portions are arranged at spatially different positions, respectively, and high frequency currents having phase difference corresponding to a spatial deviation between the high frequency magnetic field generating portions are supplied to the high frequency magnetic field generating portions, resultant high frequency magnetic fields being combined to produce a single rotating magnetic field.

摘要翻译： 高频磁场产生部分分别设置在空间上不同的位置，并且具有与高频磁场产生部分之间的空间偏差相对应的相位差的高频电流被提供给高频磁场产生部分，从而产生高频磁场产生部分 磁场被组合以产生单个旋转磁场。

公开(公告)号：US06256591B1

公开(公告)日：2001-07-03

申请号：US09091158

申请日：1998-06-09

申请人： Kiyoshi Yoda ,  Hidenobu Sakamoto ,  Yoshifuru Saitou

发明人： Kiyoshi Yoda ,  Hidenobu Sakamoto ,  Yoshifuru Saitou

IPC分类号： G06F1700

CPC分类号： A61N5/1031 ,  A61N2005/1087

摘要： The ratio a between an energy distribution vector UP is calculated by using a density distribution P, and a desired energy distribution vector V to obtain an energy source density distribution P/a. Thus, the intensity of an energy distribution can be varied, and the irradiation of unnecessary portions of the human body can be avoided when an tumor in the human body is irradiated with an energy distribution.

摘要翻译： 通过使用密度分布P和期望的能量分布矢量V来计算能量分布矢量UP之间的比率a，以获得能量密度分布P / a。 因此，可以改变能量分布的强度，并且当用能量分布照射人体中的肿瘤时，可以避免人体不必要部分的照射。

公开(公告)号：US4978918A

公开(公告)日：1990-12-18

申请号：US349213

申请日：1989-05-09

申请人： Hidenobu Sakamoto

发明人： Hidenobu Sakamoto

IPC分类号： G01R33/567 ,  G01R33/20

CPC分类号： G01R33/56316 ,  G01R33/5673

摘要： In a method of magnetic resonance imaging in which an RF magnetic field pulse, a slice magnetic field, a phase encoding magnetic field and a signal reading magnetic field are applied to a sample in a predetermined sequence for the construction of desired slice image on the basis of a magnetic resonance signal from the sample, artifacts due to moving parts of the sample under examination are removed by specific combinations of the magnetic fields.

摘要翻译： 在一种磁共振成像方法中，以预定的顺序将RF磁场脉冲，切片磁场，相位编码磁场和信号读取磁场施加到样本，以在基础上构建期望的切片图像 的来自样品的磁共振信号，通过磁场的特定组合去除由于被检样品的运动部分引起的伪像。